scholarly journals Potential role of stem cells in severe spinal cord injury: current perspectives and clinical data

2012 ◽  
pp. 15 ◽  
Author(s):  
Syed Ameer Paspala ◽  
Murthy ◽  
Rao ◽  
sandeep Vishwakarma ◽  
Aleem
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Clinical Data ◽  
Potential Role ◽  
Cord Injury

scholarly journals Hydrogels and Cell Based Therapies in Spinal Cord Injury Regeneration

2015 ◽  
Vol 2015 ◽  
pp. 1-24 ◽  
Author(s):  
Rita C. Assunção-Silva ◽  
Eduardo D. Gomes ◽  
Nuno Sousa ◽  
Nuno A. Silva ◽  
António J. Salgado
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Cell Survival ◽  
Spinal Cord Injuries ◽  
Human Stem Cells ◽  
Related Disorder ◽  
Cord Injury ◽  
Cell Carriers

Spinal cord injury (SCI) is a central nervous system- (CNS-) related disorder for which there is yet no successful treatment. Within the past several years, cell-based therapies have been explored for SCI repair, including the use of pluripotent human stem cells, and a number of adult-derived stem and mature cells such as mesenchymal stem cells, olfactory ensheathing cells, and Schwann cells. Although promising, cell transplantation is often overturned by the poor cell survival in the treatment of spinal cord injuries. Alternatively, the therapeutic role of different cells has been used in tissue engineering approaches by engrafting cells with biomaterials. The latter have the advantages of physically mimicking the CNS tissue, while promoting a more permissive environment for cell survival, growth, and differentiation. The roles of both cell- and biomaterial-based therapies as single therapeutic approaches for SCI repair will be discussed in this review. Moreover, as the multifactorial inhibitory environment of a SCI suggests that combinatorial approaches would be more effective, the importance of using biomaterials as cell carriers will be herein highlighted, as well as the recent advances and achievements of these promising tools for neural tissue regeneration.

scholarly journals Potential role of oxidative stress on the prescription of rehabilitation interventions in spinal cord injury

Spinal Cord ◽  
2013 ◽  
Vol 51 (9) ◽  
pp. 656-662 ◽  
Author(s):  
T Lam ◽  
Z Chen ◽  
M M Sayed-Ahmed ◽  
A Krassioukov ◽  
A A Al-Yahya
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Potential Role ◽  
Cord Injury

scholarly journals Hypoxia Response Element-Directed Expression of aFGF in Neural Stem Cells Promotes the Recovery of Spinal Cord Injury and Attenuates SCI-Induced Apoptosis

2021 ◽  
Vol 9 ◽  
Author(s):  
Yibo Ying ◽  
Yifan Zhang ◽  
Yurong Tu ◽  
Min Chen ◽  
Zhiyang Huang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
Acidic Fibroblast Growth Factor ◽  
Neural Structure ◽  
Cord Injury ◽  
Important Regulator ◽  
Induced Apoptosis

Reducing neuronal death after spinal cord injury (SCI) is considered to be an important strategy for the renovation of SCI. Studies have shown that, as an important regulator of the development and maintenance of neural structure, acidic fibroblast growth factor (aFGF) has the role of tissue protection and is considered to be an effective drug for the treatment of SCI. Neural stem cells (NSCs) are rendered with the remarkable characteristics to self-replace and differentiate into a variety of cells, so it is promising to be used in cell transplantation therapy. Based on the facts above, our main aim of this research is to explore the role of NSCs expressing aFGF meditated by five hypoxia-responsive elements (5HRE) in the treatment of SCI by constructing AAV–5HRE–aFGF–NSCs and transplanting it into the area of SCI. Our research results showed that AAV–5HRE–aFGF–NSCs can effectively restore the motor function of rats with SCI. This was accomplished by inhibiting the expression of caspase 12/caspase 3 pathway, EIF2α–CHOP pathway, and GRP78 protein to inhibit apoptosis.

scholarly journals Mesenchymal Stem Cells for Spinal Cord Injury: Current Options, Limitations, and Future of Cell Therapy

2019 ◽  
Vol 20 (11) ◽  
pp. 2698 ◽  
Author(s):  
Fabio Cofano ◽  
Marina Boido ◽  
Matteo Monticelli ◽  
Francesco Zenga ◽  
Alessandro Ducati ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Mesenchymal Stem Cells ◽  
Public Health Issue ◽  
Molecular Signaling ◽  
Future Perspectives ◽  
Vascular Changes ◽  
Cord Injury

Spinal cord injury (SCI) constitutes an inestimable public health issue. The most crucial phase in the pathophysiological process of SCI concerns the well-known secondary injury, which is the uncontrolled and destructive cascade occurring later with aberrant molecular signaling, inflammation, vascular changes, and secondary cellular dysfunctions. The use of mesenchymal stem cells (MSCs) represents one of the most important and promising tested strategies. Their appeal, among the other sources and types of stem cells, increased because of their ease of isolation/preservation and their properties. Nevertheless, encouraging promise from preclinical studies was followed by weak and conflicting results in clinical trials. In this review, the therapeutic role of MSCs is discussed, together with their properties, application, limitations, and future perspectives.

The potential role of heat shock proteins in acute spinal cord injury

2014 ◽  
Vol 23 (7) ◽  
pp. 1480-1490 ◽  
Author(s):  
Yijun Zhou ◽  
Leilei Xu ◽  
Xinghua Song ◽  
Liwen Ding ◽  
Jiangtao Chen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Potential Role ◽  
Acute Spinal Cord Injury ◽  
Cord Injury ◽  
Shock Proteins

scholarly journals Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury

2022 ◽  
Vol 2022 ◽  
pp. 1-34
Author(s):  
Sajad Fakhri ◽  
Fatemeh Abbaszadeh ◽  
Seyed Zachariah Moradi ◽  
Hui Cao ◽  
Haroon Khan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Secondary Metabolites ◽  
Potential Role ◽  
Therapeutic Agents ◽  
Cord Injury ◽  
Potential Alternative ◽  
Preclinical And Clinical Studies

Despite the progression in targeting the complex pathophysiological mechanisms of neurodegenerative diseases (NDDs) and spinal cord injury (SCI), there is a lack of effective treatments. Moreover, conventional therapies suffer from associated side effects and low efficacy, raising the need for finding potential alternative therapies. In this regard, a comprehensive review was done regarding revealing the main neurological dysregulated pathways and providing alternative therapeutic agents following SCI. From the mechanistic point, oxidative stress and inflammatory pathways are major upstream orchestras of cross-linked dysregulated pathways (e.g., apoptosis, autophagy, and extrinsic mechanisms) following SCI. It urges the need for developing multitarget therapies against SCI complications. Polyphenols, as plant-derived secondary metabolites, have the potential of being introduced as alternative therapeutic agents to pave the way for treating SCI. Such secondary metabolites presented modulatory effects on neuronal oxidative stress, neuroinflammatory, and extrinsic axonal dysregulated pathways in the onset and progression of SCI. In the present review, the potential role of phenolic compounds as critical phytochemicals has also been revealed in regulating upstream dysregulated oxidative stress/inflammatory signaling mediators and extrinsic mechanisms of axonal regeneration after SCI in preclinical and clinical studies. Additionally, the coadministration of polyphenols and stem cells has shown a promising strategy for improving post-SCI complications.

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