scholarly journals Potential role of oxidative stress on the prescription of rehabilitation interventions in spinal cord injury

Spinal Cord ◽  
2013 ◽  
Vol 51 (9) ◽  
pp. 656-662 ◽  
Author(s):  
T Lam ◽  
Z Chen ◽  
M M Sayed-Ahmed ◽  
A Krassioukov ◽  
A A Al-Yahya
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Potential Role ◽  
Cord Injury

scholarly journals Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury

2022 ◽  
Vol 2022 ◽  
pp. 1-34
Author(s):  
Sajad Fakhri ◽  
Fatemeh Abbaszadeh ◽  
Seyed Zachariah Moradi ◽  
Hui Cao ◽  
Haroon Khan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Secondary Metabolites ◽  
Potential Role ◽  
Therapeutic Agents ◽  
Cord Injury ◽  
Potential Alternative ◽  
Preclinical And Clinical Studies

Despite the progression in targeting the complex pathophysiological mechanisms of neurodegenerative diseases (NDDs) and spinal cord injury (SCI), there is a lack of effective treatments. Moreover, conventional therapies suffer from associated side effects and low efficacy, raising the need for finding potential alternative therapies. In this regard, a comprehensive review was done regarding revealing the main neurological dysregulated pathways and providing alternative therapeutic agents following SCI. From the mechanistic point, oxidative stress and inflammatory pathways are major upstream orchestras of cross-linked dysregulated pathways (e.g., apoptosis, autophagy, and extrinsic mechanisms) following SCI. It urges the need for developing multitarget therapies against SCI complications. Polyphenols, as plant-derived secondary metabolites, have the potential of being introduced as alternative therapeutic agents to pave the way for treating SCI. Such secondary metabolites presented modulatory effects on neuronal oxidative stress, neuroinflammatory, and extrinsic axonal dysregulated pathways in the onset and progression of SCI. In the present review, the potential role of phenolic compounds as critical phytochemicals has also been revealed in regulating upstream dysregulated oxidative stress/inflammatory signaling mediators and extrinsic mechanisms of axonal regeneration after SCI in preclinical and clinical studies. Additionally, the coadministration of polyphenols and stem cells has shown a promising strategy for improving post-SCI complications.

scholarly journals HDAC6 Regulates the Chaperone-Mediated Autophagy to Prevent Oxidative Damage in Injured Neurons after Experimental Spinal Cord Injury

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Min Su ◽  
Huaqing Guan ◽  
Fan Zhang ◽  
Yarong Gao ◽  
Xiaomei Teng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Potential Role ◽  
Mechanical Trauma ◽  
Ros Generation ◽  
Histone Deacetylase 6 ◽  
Cord Injury ◽  
Chaperone Mediated Autophagy

Hypoxia-ischemia- (HI-) induced oxidative stress plays a role in secondary pathocellular processes of acute spinal cord injury (SCI) due to HI from many kinds of mechanical trauma. Increasing evidence suggests that the histone deacetylase-6 (HDAC6) plays an important role in cell homeostasis in both physiological and abnormal, stressful, pathological conditions. This paper found that inhibition of HDAC6 accelerated reactive oxygen species (ROS) generation and cell apoptosis in response to the HI. Deficiency of HDAC6 hindered the chaperone-mediated autophagy (CMA) activity to resistance of HI-induced oxidative stress. Furthermore, this study provided the experimental evidence for the potential role of HDAC6 in the regulation of CMA by affecting HSP90 acetylation. Therefore, HDAC6 plays an important role in the function of CMA pathway under the HI stress induced by SCI and it may be a potential therapeutic target in acute SCI model.

Protective role of β-carotene against oxidative stress and neuroinflammation in a rat model of spinal cord injury

2018 ◽  
Vol 61 ◽  
pp. 92-99 ◽  
Author(s):  
Lihui Zhou ◽  
Lian Ouyang ◽  
Shuangzhi Lin ◽  
Song Chen ◽  
YingJie Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rat Model ◽  
Protective Role ◽  
Cord Injury ◽  
Β Carotene

The potential role of heat shock proteins in acute spinal cord injury

2014 ◽  
Vol 23 (7) ◽  
pp. 1480-1490 ◽  
Author(s):  
Yijun Zhou ◽  
Leilei Xu ◽  
Xinghua Song ◽  
Liwen Ding ◽  
Jiangtao Chen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Potential Role ◽  
Acute Spinal Cord Injury ◽  
Cord Injury ◽  
Shock Proteins

Potential Role of Growth Factors in the Management of Spinal Cord Injury

2015 ◽  
Vol 83 (1) ◽  
pp. 120-131 ◽  
Author(s):  
Basem I. Awad ◽  
Margaret A. Carmody ◽  
Michael P. Steinmetz
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Growth Factors ◽  
Potential Role ◽  
Cord Injury

scholarly journals Erratum to: The potential role of heat shock proteins in acute spinal cord injury

2014 ◽  
Vol 23 (7) ◽  
pp. 1582-1582
Author(s):  
Yijun Zhou ◽  
Leilei Xu ◽  
Xinghua Song ◽  
Liwen Ding ◽  
Jiangtao Chen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Potential Role ◽  
Acute Spinal Cord Injury ◽  
Cord Injury ◽  
Shock Proteins
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