scholarly journals Treating patients with movement disorders using MRI-guided focused ultrasound: recent developments and challenges

2015 ◽  
pp. 5
Author(s):  
Travis Tierney ◽  
Wesley Field ◽  
Tharakeswari Selvakumar ◽  
Michael Hayes
Keyword(s):  
Movement Disorders ◽  
Focused Ultrasound ◽  
Recent Developments ◽  
Mri Guided

scholarly journals MRI Guided Focused Ultrasound-Mediated Delivery of Therapeutic Cells to the Brain: A Review of the State-of-the-Art Methodology and Future Applications

2021 ◽  
Vol 12 ◽  
Author(s):  
Nabid Ahmed ◽  
Dheeraj Gandhi ◽  
Elias R. Melhem ◽  
Victor Frenkel
Keyword(s):  
Focused Ultrasound ◽  
Immune Cell ◽  
Intrathecal Injection ◽  
Therapeutic Modality ◽  
Growth Factor Delivery ◽  
Cellular Delivery ◽  
Cell Therapies ◽  
Recent Developments ◽  
Mri Guided ◽  
The Brain

Stem cell and immune cell therapies are being investigated as a potential therapeutic modality for CNS disorders, performing functions such as targeted drug or growth factor delivery, tumor cell destruction, or inflammatory regulation. Despite promising preclinical studies, delivery routes for maximizing cell engraftment, such as stereotactic or intrathecal injection, are invasive and carry risks of hemorrhage and infection. Recent developments in MRI-guided focused ultrasound (MRgFUS) technology have significant implications for treating focal CNS pathologies including neurodegenerative, vascular and malignant processes. MRgFUS is currently employed in the clinic for treating essential tremor and Parkinson's Disease by producing precise, incisionless, transcranial lesions. This non-invasive technology can also be modified for non-destructive applications to safely and transiently open the blood-brain barrier (BBB) to deliver a range of therapeutics, including cells. This review is meant to familiarize the neuro-interventionalist with this topic and discusses the use of MRgFUS for facilitating cellular delivery to the brain. A detailed and comprehensive description is provided on routes of cell administration, imaging strategies for targeting and tracking cellular delivery and engraftment, biophysical mechanisms of BBB enhanced permeability, supportive proof-of-concept studies, and potential for clinical translation.

MRI guided focused ultrasound for movement disorders-report of 56 consecutive cases

2017 ◽  
Vol 381 ◽  
pp. 124-125
Author(s):  
I. Schlesinger ◽  
A. Sinai ◽  
M. Nassar ◽  
A. Eran ◽  
M. Zaaroor
Keyword(s):  
Movement Disorders ◽  
Focused Ultrasound ◽  
Mri Guided

scholarly journals AAPM Task Group 241: A Medical Physicist’s Guide to MRI‐guided Focused Ultrasound Body Systems

2021 ◽  
Author(s):  
Allison Payne ◽  
Rajiv Chopra ◽  
Nicholas Ellens ◽  
Lili Chen ◽  
Pejman Ghanouni ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Task Group ◽  
Mri Guided

Invited. On the feasibility of MRI-guided focused ultrasound for local induction of gene expression

1998 ◽  
Vol 8 (1) ◽  
pp. 101-104 ◽  
Author(s):  
David P. Madio ◽  
Peter van Gelderen ◽  
Daryl DesPres ◽  
Alan W. Olson ◽  
Jacco A. de Zwart ◽  
...  
Keyword(s):  
Gene Expression ◽  
Focused Ultrasound ◽  
Mri Guided

scholarly journals MRI-guided focused ultrasound ablation of lumbar medial branch nerve: Feasibility and safety study in a swine model

2016 ◽  
Vol 32 (7) ◽  
pp. 786-794 ◽  
Author(s):  
Elena A. Kaye ◽  
Sebastien Monette ◽  
Govindarajan Srimathveeravalli ◽  
Majid Maybody ◽  
Stephen B. Solomon ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Swine Model ◽  
Medial Branch ◽  
Safety Study ◽  
Ultrasound Ablation ◽  
Mri Guided ◽  
Focused Ultrasound Ablation

scholarly journals A dual-mode hemispherical sparse array for 3D passive acoustic mapping and skull localization within a clinical MRI guided focused ultrasound device

2018 ◽  
Vol 63 (6) ◽  
pp. 065008 ◽  
Author(s):  
Calum Crake ◽  
Spencer T Brinker ◽  
Christian M Coviello ◽  
Margaret S Livingstone ◽  
Nathan J McDannold
Keyword(s):  
Focused Ultrasound ◽  
Dual Mode ◽  
Sparse Array ◽  
Ultrasound Device ◽  
Mri Guided ◽  
Passive Acoustic ◽  
Acoustic Mapping ◽  
Clinical Mri

scholarly journals A single case of MRI-guided focused ultrasound ventro-oral thalamotomy for musician’s dystonia

2019 ◽  
Vol 131 (2) ◽  
pp. 384-386 ◽  
Author(s):  
Shiro Horisawa ◽  
Toshio Yamaguchi ◽  
Keiichi Abe ◽  
Hiroki Hori ◽  
Masatake Sumi ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Single Case ◽  
Musical Instruments ◽  
Dramatic Improvement ◽  
Classical Guitar ◽  
Focal Lesions ◽  
Musical Play ◽  
Mri Guided ◽  
The Right ◽  
Hand Dystonia

Musician’s dystonia (MD) is a type of focal hand dystonia that develops only while playing musical instruments and interferes with skilled and fine movements. Lesioning of the ventro-oral (Vo) nucleus of the thalamus (Vo-thalamotomy) using radiofrequency can cause dramatic improvement in MD symptoms. Focused ultrasound (FUS) can make intracranial focal lesions without an incision. The authors used MRI-guided FUS (MRgFUS) to create a lesion on the Vo nucleus to treat a patient with MD. Tubiana’s MD scale (TMDS) was used to evaluate the condition of musical play ranging from 1 to 5 (1: worst, 5: best). The patient was a 35-year-old right-handed man with involuntary flexion of the right second, third, and fourth fingers, which occurred while playing a classical guitar. Immediately after therapeutic sonications of FUS Vo-thalamotomy, there was dramatic improvement in the MD symptoms. The TMDS scores before; at 0 and 1 week after; and at 1, 3, 6, and 12 months after MRgFUS Vo-thalamotomy were 1, 4, 4, 5, 5, 5, and 5, respectively. No complications were observed. Focused ultrasound Vo-thalamotomy can be an effective treatment for MD.

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