scholarly journals AAPM Task Group 241: A Medical Physicist’s Guide to MRI‐guided Focused Ultrasound Body Systems

2021 ◽  
Author(s):  
Allison Payne ◽  
Rajiv Chopra ◽  
Nicholas Ellens ◽  
Lili Chen ◽  
Pejman Ghanouni ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Task Group ◽  
Mri Guided

Invited. On the feasibility of MRI-guided focused ultrasound for local induction of gene expression

1998 ◽  
Vol 8 (1) ◽  
pp. 101-104 ◽  
Author(s):  
David P. Madio ◽  
Peter van Gelderen ◽  
Daryl DesPres ◽  
Alan W. Olson ◽  
Jacco A. de Zwart ◽  
...  
Keyword(s):  
Gene Expression ◽  
Focused Ultrasound ◽  
Mri Guided

scholarly journals MRI-guided focused ultrasound ablation of lumbar medial branch nerve: Feasibility and safety study in a swine model

2016 ◽  
Vol 32 (7) ◽  
pp. 786-794 ◽  
Author(s):  
Elena A. Kaye ◽  
Sebastien Monette ◽  
Govindarajan Srimathveeravalli ◽  
Majid Maybody ◽  
Stephen B. Solomon ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Swine Model ◽  
Medial Branch ◽  
Safety Study ◽  
Ultrasound Ablation ◽  
Mri Guided ◽  
Focused Ultrasound Ablation

scholarly journals A dual-mode hemispherical sparse array for 3D passive acoustic mapping and skull localization within a clinical MRI guided focused ultrasound device

2018 ◽  
Vol 63 (6) ◽  
pp. 065008 ◽  
Author(s):  
Calum Crake ◽  
Spencer T Brinker ◽  
Christian M Coviello ◽  
Margaret S Livingstone ◽  
Nathan J McDannold
Keyword(s):  
Focused Ultrasound ◽  
Dual Mode ◽  
Sparse Array ◽  
Ultrasound Device ◽  
Mri Guided ◽  
Passive Acoustic ◽  
Acoustic Mapping ◽  
Clinical Mri

scholarly journals A single case of MRI-guided focused ultrasound ventro-oral thalamotomy for musician’s dystonia

2019 ◽  
Vol 131 (2) ◽  
pp. 384-386 ◽  
Author(s):  
Shiro Horisawa ◽  
Toshio Yamaguchi ◽  
Keiichi Abe ◽  
Hiroki Hori ◽  
Masatake Sumi ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Single Case ◽  
Musical Instruments ◽  
Dramatic Improvement ◽  
Classical Guitar ◽  
Focal Lesions ◽  
Musical Play ◽  
Mri Guided ◽  
The Right ◽  
Hand Dystonia

Musician’s dystonia (MD) is a type of focal hand dystonia that develops only while playing musical instruments and interferes with skilled and fine movements. Lesioning of the ventro-oral (Vo) nucleus of the thalamus (Vo-thalamotomy) using radiofrequency can cause dramatic improvement in MD symptoms. Focused ultrasound (FUS) can make intracranial focal lesions without an incision. The authors used MRI-guided FUS (MRgFUS) to create a lesion on the Vo nucleus to treat a patient with MD. Tubiana’s MD scale (TMDS) was used to evaluate the condition of musical play ranging from 1 to 5 (1: worst, 5: best). The patient was a 35-year-old right-handed man with involuntary flexion of the right second, third, and fourth fingers, which occurred while playing a classical guitar. Immediately after therapeutic sonications of FUS Vo-thalamotomy, there was dramatic improvement in the MD symptoms. The TMDS scores before; at 0 and 1 week after; and at 1, 3, 6, and 12 months after MRgFUS Vo-thalamotomy were 1, 4, 4, 5, 5, 5, and 5, respectively. No complications were observed. Focused ultrasound Vo-thalamotomy can be an effective treatment for MD.

MRI-guided Focused Ultrasound Ablation for Localized Intermediate-Risk Prostate Cancer: Early Results of a Phase II Trial

Radiology ◽  
2021 ◽  
Vol 298 (3) ◽  
pp. 695-703 ◽  
Author(s):  
Sangeet Ghai ◽  
Antonio Finelli ◽  
Kateri Corr ◽  
Rosanna Chan ◽  
Sarah Jokhu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Phase Ii ◽  
Focused Ultrasound ◽  
Phase Ii Trial ◽  
Intermediate Risk ◽  
Early Results ◽  
Risk Prostate Cancer ◽  
Ultrasound Ablation ◽  
Mri Guided ◽  
Focused Ultrasound Ablation

scholarly journals BOT-01 BLOOD-BRAIN BARRIER OPENING USING 220-KHZ TRANSCRANIAL MRI-GUIDED FOCUSED ULTRASOUND AND MICROBUBBLES IN MOUSE AND RAT

2019 ◽  
Vol 1 (Supplement_2) ◽  
pp. ii12-ii12
Author(s):  
Michiharu Yoshida ◽  
Kazuo Maruyama ◽  
Yasutaka Kato ◽  
Rachmilevitch Itay ◽  
Syuji Suzuki ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Blood Brain Barrier ◽  
Focused Ultrasound ◽  
Brain Barrier ◽  
Maximum Temperature ◽  
Non Invasive ◽  
Therapeutic Drugs ◽  
Blood Brain ◽  
Mri Guided ◽  
Bbb Opening

Abstract OBJECTIVE In neuro-oncology, it is believed that one major obstacle to effective chemotherapy is the high vascularity and heterogenous permeability of brain tumors. Focused ultrasound (FUS) exposure with the microbubbles has been shown to transiently open the blood-brain barrier (BBB) without depositing thermal energy, and thus may enhance the delivery of various therapeutic drugs into brain tumors. The aim of this study was to evaluate the BBB opening using 220-kHz transcranial MRI-guided FUS (TcMRgFUS) device and microbubbles in mouse and rat. METHODS The experiments were performed with the 220-kHz ExAblate Neuro TcMRgFUS system (InSightec) and novel lipid bubbles (LB, Teikyo Univ.). Normal mouse and rat brains were irradiated with TcMRgFUS (output power, 5W; duration of irradiation, 30 s; duty cycle 100%) following intravenous injection of 6x107 LB per mouse and rat, respectively. On irradiation, target temperature rise & cavitation signal were monitored by MR thermometry and cavitation receiver, respectively. Immediately after irradiation, BBB opening and complications were detected based on T1, T2, T2*, and Gadolinium (Gd) enhanced T1-weighted images. RESULTS The maximum temperature of brain tissue was under 42 C. There were no risky-cavitation signals causing hemorrhage. The FUS-LB exposure induced successful BBB opening effect in both mouse and rat, confirmed by Gd enhancement in the target region, lateral ventricles, and sulcus. In addition, there were no complications such as edema, coagulation, and hemorrhage. CONCLUSIONS Although there remain many conditions to be optimized, BBB opening using a 220-kHz TcMRgFUS device and LB can offer a non-invasive and feasible drug delivery for brain malignancies.

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