scholarly journals Current perspectives on the role of TRAMP in nuclear RNA surveillance and quality control

2015 ◽  
pp. 111 ◽  
Author(s):  
Chi-Ming Wong ◽  
Pan Kewu ◽  
Huang Zhe ◽  
Jimmy TH Lee
Keyword(s):  
Quality Control ◽  
Rna Surveillance ◽  
Nuclear Rna

scholarly journals Nuclear RNA surveillance: role of TRAMP in controlling exosome specificity

2013 ◽  
Vol 4 (2) ◽  
pp. 217-231 ◽  
Author(s):  
Karyn Schmidt ◽  
J. Scott Butler
Keyword(s):  
Rna Surveillance ◽  
Nuclear Rna

scholarly journals Cellular RNA surveillance in health and disease

Science ◽  
2019 ◽  
Vol 366 (6467) ◽  
pp. 822-827 ◽  
Author(s):  
Sandra L. Wolin ◽  
Lynne E. Maquat
Keyword(s):  
Quality Control ◽  
Noncoding Rnas ◽  
Messenger Rnas ◽  
Interferon Production ◽  
Developmental Defects ◽  
Protein Coding ◽  
Ribonucleic Acids ◽  
Rna Surveillance ◽  
Health And Disease

The numerous quality control pathways that target defective ribonucleic acids (RNAs) for degradation play key roles in shaping mammalian transcriptomes and preventing disease. These pathways monitor most steps in the biogenesis of both noncoding RNAs (ncRNAs) and protein-coding messenger RNAs (mRNAs), degrading ncRNAs that fail to form functional complexes with one or more proteins and eliminating mRNAs that encode abnormal, potentially toxic proteins. Mutations in components of diverse RNA surveillance pathways manifest as disease. Some mutations are characterized by increased interferon production, suggesting that a major role of these pathways is to prevent aberrant cellular RNAs from being recognized as “non-self.” Other mutations are common in cancer, or result in developmental defects, revealing the importance of RNA surveillance to cell and organismal function.

scholarly journals Fast and Efficient 5′P Degradome Library Preparation for Analysis of Co-Translational Decay in Arabidopsis

Plants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 466
Author(s):  
Marie-Christine Carpentier ◽  
Cécile Bousquet-Antonelli ◽  
Rémy Merret
Keyword(s):  
Gene Expression ◽  
Quality Control ◽  
Transcriptional Regulation ◽  
High Throughput ◽  
Library Preparation ◽  
Working Day ◽  
Set Up ◽  
Post Transcriptional Regulation ◽  
Commercial Kit

The recent development of high-throughput technologies based on RNA sequencing has allowed a better description of the role of post-transcriptional regulation in gene expression. In particular, the development of degradome approaches based on the capture of 5′monophosphate decay intermediates allows the discovery of a new decay pathway called co-translational mRNA decay. Thanks to these approaches, ribosome dynamics could now be revealed by analysis of 5′P reads accumulation. However, library preparation could be difficult to set-up for non-specialists. Here, we present a fast and efficient 5′P degradome library preparation for Arabidopsis samples. Our protocol was designed without commercial kit and gel purification and can be easily done in one working day. We demonstrated the robustness and the reproducibility of our protocol. Finally, we present the bioinformatic reads-outs necessary to assess library quality control.

scholarly journals TTC3-Mediated Protein Quality Control, A Potential Mechanism for Cognitive Impairment

2021 ◽  
Author(s):  
Xu Zhou ◽  
Xiongjin Chen ◽  
Tingting Hong ◽  
Miaoping Zhang ◽  
Yujie Cai ◽  
...  
Keyword(s):  
Quality Control ◽  
Cognitive Impairment ◽  
Protein Quality ◽  
Protein Quality Control ◽  
Ubiquitin Proteasome System ◽  
Research Progress ◽  
Repeat Domain ◽  
Ubiquitin Proteasome ◽  
Domain 3

AbstractThe tetrapeptide repeat domain 3 (TTC3) gene falls within Down's syndrome (DS) critical region. Cognitive impairment is a common phenotype of DS and Alzheimer’s disease (AD), and overexpression of TTC3 can accelerate cognitive decline, but the specific mechanism is unknown. The TTC3-mediated protein quality control (PQC) mechanism, similar to the PQC system, is divided into three parts: it acts as a cochaperone to assist proteins in folding correctly; it acts as an E3 ubiquitin ligase (E3s) involved in protein degradation processes through the ubiquitin–proteasome system (UPS); and it may also eventually cause autophagy by affecting mitochondrial function. Thus, this article reviews the research progress on the structure, function, and metabolism of TTC3, including the recent research progress on TTC3 in DS and AD; the role of TTC3 in cognitive impairment through PQC in combination with the abovementioned attributes of TTC3; and the potential targets of TTC3 in the treatment of such diseases.

scholarly journals Integrity of SRP RNA is ensured by La and the nuclear RNA quality control machinery

2014 ◽  
Vol 42 (16) ◽  
pp. 10698-10710 ◽  
Author(s):  
Eileen Leung ◽  
Claudia Schneider ◽  
Fu Yan ◽  
Hatem Mohi-El-Din ◽  
Grzegorz Kudla ◽  
...  
Keyword(s):  
Quality Control ◽  
Rna Quality ◽  
Nuclear Rna ◽  
Rna Quality Control ◽  
Srp Rna

scholarly journals Moving beyond quality control in diagnostic radiology and the role of the clinically qualified medical physicist

2017 ◽  
Vol 41 ◽  
pp. 104-108 ◽  
Author(s):  
H. Delis ◽  
K. Christaki ◽  
B. Healy ◽  
G. Loreti ◽  
G.L. Poli ◽  
...  
Keyword(s):  
Quality Control ◽  
Diagnostic Radiology ◽  
Medical Physicist

The Role of the Lectin Calnexin in Conformation Independent Binding to N-Linked Glycoproteins and Quality Control

1998 ◽  
pp. 105-116 ◽  
Author(s):  
John J. M. Bergeron ◽  
A. Zapun ◽  
W.-J. Ou ◽  
R. Hemming ◽  
F. Parlati ◽  
...  
Keyword(s):  
Quality Control
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