scholarly journals The Physician Global Assessment and Body Surface Area composite tool is a simple alternative to the Psoriasis Area and Severity Index for assessment of psoriasis: post hoc analysis from PRISTINE and PRESTA

2018 ◽  
Vol Volume 8 ◽  
pp. 65-74
Author(s):  
Jessica A Walsh ◽  
Heather Jones ◽  
Lotus Mallbris ◽  
Kristina Callis Duffin ◽  
Gerald G Krueger ◽  
...  
Keyword(s):  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Global Assessment ◽  
Severity Index ◽  
Physician Global Assessment ◽  
Post Hoc Analysis ◽  
Composite Tool ◽  
Simple Alternative ◽  
Post Hoc

Psoriasis: Moderne Versorgung braucht einen ganzheitlichen Ansatz

2019 ◽  
pp. 196-197
Author(s):  
Natalia Kirsten
Keyword(s):  
Surface Area ◽  
Body Surface Area ◽  
Body Mass ◽  
Body Surface ◽  
Vitamin D3 ◽  
Severity Index ◽  
Serum Concentrations ◽  
Depression Severity ◽  
Interleukin 18 ◽  
Psoriasis Area Severity Index

Objective: Psoriasis and depression may have common mechanisms, such as systemic inflammation, dysfunction of the hypothalamic-pituitary-adrenal axis, and vitamin D3 deficiency. Among men with psoriasis, this study examined whether depression severity was associated with serum concentrations of different metabolic and inflammatory markers.Methods: The study included 85 men with psoriasis (mean age ±standard deviation [SD], 47 ±14 years) and 65 men without psoriasis (mean age ±SD, 44 ±13 years). In both groups, we measured the body mass index; blood pressure; and serum concentrations of lipids, uric acid, lipase, interleukins 6 and 18, cortisol, and 25-hydroxyvitamin D3. All participants completed the Beck Depression Inventory. Other variables analyzed included psoriasis duration, the Psoriasis Area Severity Index, and the percentage of body surface area affected by psoriatic lesions.Results: Compared with controls, patients with psoriasis had significantly greater depression severity, higher body mass indices, and higher serum concentrations of total cholesterol and interleukins 6 and 18; moreover, they had significantly lower serum 25-hydroxyvitamin D3 concentrations. In patients with psoriasis, depression severity correlated positively with psoriasis duration, the Psoriasis Area Severity Index, the percentage of body surface area affected by psoriatic lesions, and interleukin-18 concentration. In patients with psoriasis, depression severity correlated negatively with 25-hydroxyvitamin D3 concentration, but it did not correlate significantly with the serum concentrations of interleukin 6 and cortisol. Conclusion: High concentrations of interleukin 18 and low concentrations of 25-hydroxyvitamin D3 may be associated with depression severity in men with psoriasis. Thus, further studies should examine whether effective anti-inflammatory treatments or vitamin D3 supplementation can improve depression outcomes in these patients.

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