scholarly journals Association of CYP3A5 Gene Polymorphisms and Amlodipine-Induced Peripheral Edema in Chinese Han Patients with Essential Hypertension

2021 ◽  
Vol Volume 14 ◽  
pp. 189-197
Author(s):  
Hao Liang ◽  
Xinru Zhang ◽  
Zhuo Ma ◽  
Yan Sun ◽  
Chang Shu ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Gene Polymorphisms ◽  
Chinese Han ◽  
Peripheral Edema ◽  
Cyp3a5 Gene

scholarly journals CYP4F2 and CYP3A5 gene polymorphisms and lung cancer in Chinese Han population

2020 ◽  
Vol 20 (3) ◽  
pp. 461-468
Author(s):  
Ruiqing He ◽  
Meng Li ◽  
Anqi Li ◽  
Wenhui Dang ◽  
Tian Yang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Cyp3a5 Gene

scholarly journals Association of ATP6AP2 Gene Polymorphisms with Essential Hypertension in a south Chinese Han Population

2015 ◽  
Vol 16 (17) ◽  
pp. 8017-8018 ◽  
Author(s):  
Yan Wang ◽  
Mei-Hua Bao ◽  
Qing-Song Zhang ◽  
Jian-Ming Li ◽  
Liang Tang
Keyword(s):  
Essential Hypertension ◽  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Genetic association of TOLLIP gene polymorphisms and HIV infection: a case-control study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ming-Gui Wang ◽  
Jing Wang ◽  
Jian-Qing He
Keyword(s):  
Hiv Infection ◽  
Gene Polymorphisms ◽  
Case Control Study ◽  
Binary Logistic Regression ◽  
Case Control ◽  
Additive Models ◽  
Chinese Han ◽  
Interacting Protein ◽  
Control Study ◽  
Age And Sex

Abstract Background Previous studies have indicated that host genetic factors play an essential role in immunity to human immunodeficiency virus (HIV) infection. We aimed to investigate the association between the toll-interacting protein (TOLLIP) and mannose-binding lectin 2 (MBL2) genes and HIV infection susceptibility among Chinese Han patients. Methods This is a case-control study. A total of 435 HIV-infected patients and 1013 seronegative healthy individuals were recruited. DNA was extracted from whole blood. Two SNPs in the MBL2 gene (rs7096206 and rs1800450) and three SNPs in the TOLLIP gene (rs5743899, rs3750920, and rs5743867) were selected and genotyped using a SNPscan Kit (Cat#: G0104, Genesky Biotechnologies Inc., Shanghai, China). Odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated using unconditional binary logistic regression. Results A significant association between the minor alleles rs5743899 (C allele) and rs5743867 (G allele) in the TOLLIP gene and susceptibility to HIV infection was found in this study after adjusting for age and sex (Pa = 0.011 and < 0.001, respectively). The rs5743867 in the TOLLIP gene was significantly associated with the risk of HIV infection in dominant, recessive, and additive models when adjusted for age and sex (Pa < 0.05). No significant association was found between MBL2 gene polymorphisms and HIV infection. Conclusion Our study found a statistically significant association between the two SNPs (rs5743867 and rs5743899) in the TOLLIP gene and susceptibility to HIV infection in a Chinese Han population.

scholarly journals Haplotype-based association study between PRCP gene polymorphisms and essential hypertension in Hani minority group from a remote region of China

2020 ◽  
Vol 21 (4) ◽  
pp. 147032032098131
Author(s):  
Yanrui Wu ◽  
Xingming Pan ◽  
Xiaoxiao Jin
Keyword(s):  
Essential Hypertension ◽  
Gene Polymorphisms ◽  
Minority Group ◽  
Normal Subjects ◽  
Nucleotide Polymorphisms ◽  
Remote Region ◽  
Kinin System ◽  
Average Blood Pressure ◽  
Genetic Impact ◽  
Kallikrein Kinin System

Objective: Prolylcarboxypeptidase (PRCP) is both involved in the Kallikrein-Kinin system (KKS) and renin-angiotensin-aldosterone system (RAAS). This study aimed to determine the genetic impact of PRCP gene polymorphisms on essential hypertension (EH) in an isolated population from a remote region of China. Methods: A haplotype-based study was investigated in 346 EH patients and 346 normal subjects and all samples were Hani minority residents in Southwest China. A total of 11 tag single nucleotide polymorphisms (SNPs) in PRCP gene were tested by polymerase chain reaction-restriction fragment length polymorphism method. Results: Single site analysis found that PRCP gene 3′UTR SNP rs3750931 was associated with EH. The minor allele G of rs3750931 was more prevalent in the EH patients compared to control subjects after Bonferroni correction ( p < 0.05). Moreover, the rs3750931 G allele carriers showed higher average blood pressure (BP) level among the subjects. The H2 (GAGCACTAACA) haplotype without rs3750931 G allele showed the protective effect for EH (OR = 0.68, 95 CI 0.54–0.85, p = 0.001). Conclusion: The present study indicated PRCP gene rs3750931 was associated with the risk of EH. This SNP G allele could be considered as one of risk markers for EH in Hani population.

scholarly journals Association of interleukin-18 gene polymorphisms with Takayasu arteritis in a Chinese Han population

2020 ◽  
Vol 133 (19) ◽  
pp. 2315-2320
Author(s):  
Dan Wen ◽  
Xian-Liang Zhou ◽  
Xin Du ◽  
Jian-Zeng Dong ◽  
Chang-Sheng Ma
Keyword(s):  
Takayasu Arteritis ◽  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Interleukin 18 ◽  
Chinese Han ◽  
Han Population
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