scholarly journals Pharmacodynamic genetic polymorphisms affect adverse drug reactions of haloperidol in patients with alcohol-use disorder

2017 ◽  
Vol Volume 10 ◽  
pp. 209-215 ◽  
Author(s):  
Michael Sergeevich Zastrozhin ◽  
Vadim Brodyansky ◽  
Valentin Skryabin ◽  
Elena Grishina ◽  
Dmitry Ivashchenko ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Genetic Polymorphisms ◽  
Adverse Drug Reactions ◽  
Alcohol Use Disorder ◽  
Drug Reactions

scholarly journals Effects of CYP2D6 genetic polymorphisms on the efficacy and safety of fluvoxamine in patients with depressive disorder and comorbid alcohol use disorder

2018 ◽  
Vol Volume 11 ◽  
pp. 113-119 ◽  
Author(s):  
Mikhail S Zastrozhin ◽  
Elena A Grishina ◽  
Nataliya P Denisenko ◽  
Valentin Yu Skryabin ◽  
Dmitry D Markov ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Depressive Disorder ◽  
Genetic Polymorphisms ◽  
Alcohol Use Disorder ◽  
Efficacy And Safety

scholarly journals Impact of Cigarette and Alcohol Use on Adverse Drug Reactions of Haart Therapy Among HIV/AIDS Patients

2014 ◽  
Vol 17 (7) ◽  
pp. A802-A803
Author(s):  
A.H. Khan ◽  
S.A. Syed Sulaiman ◽  
K. Khan ◽  
C.T. Soo ◽  
A. Akhtar
Keyword(s):  
Alcohol Use ◽  
Adverse Drug Reactions ◽  
Drug Reactions ◽  
Aids Patients ◽  
Haart Therapy ◽  
Hiv Aids

scholarly journals Development of a Pharmacogenetic Lab-on-Chip Assay Based on the In-Check Technology to Screen for Genetic Variations Associated to Adverse Drug Reactions to Common Chemotherapeutic Agents

Biosensors ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 202
Author(s):  
Rosario Iemmolo ◽  
Valentina La Cognata ◽  
Giovanna Morello ◽  
Maria Guarnaccia ◽  
Mariamena Arbitrio ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Adverse Drug Reactions ◽  
Limit Of Detection ◽  
Chemotherapeutic Agents ◽  
Clinical Diagnostics ◽  
Individual Risk ◽  
Chip Assay ◽  
Drug Reactions ◽  
Lab On Chip ◽  
On Chip

Background: Antineoplastic agents represent the most common class of drugs causing Adverse Drug Reactions (ADRs). Mutant alleles of genes coding for drug-metabolizing enzymes are the best studied individual risk factors for these ADRs. Although the correlation between genetic polymorphisms and ADRs is well-known, pharmacogenetic tests are limited to centralized laboratories with expensive or dedicated instrumentation used by specialized personnel. Nowadays, DNA chips have overcome the major limitations in terms of sensibility, specificity or small molecular detection, allowing the simultaneous detection of several genetic polymorphisms with time and costs-effective advantages. In this work, we describe the design of a novel silicon-based lab-on-chip assay able to perform low-density and high-resolution multi-assay analysis (amplification and hybridization reactions) on the In-Check platform. Methods: The novel lab-on-chip was used to screen 17 allelic variants of three genes associated with adverse reactions to common chemotherapeutic agents: DPYD (Dihydropyrimidine dehydrogenase), MTHFR (5,10-Methylenetetrahydrofolate reductase) and TPMT (Thiopurine S-methyltransferase). Results: Inter- and intra assay variability were performed to assess the specificity and sensibility of the chip. Linear regression was used to assess the optimal hybridization temperature set at 52 °C (R2 ≈ 0.97). Limit of detection was 50 nM. Conclusions: The high performance in terms of sensibility and specificity of this lab-on-chip supports its further translation to clinical diagnostics, where it may effectively promote precision medicine.

Effects of CYP2C19*17 Genetic Polymorphisms on the Steady-State Concentration of Diazepam in Patients With Alcohol Withdrawal Syndrome

2020 ◽  
pp. 001857872093175
Author(s):  
Valentin Yurievich Skryabin ◽  
Mikhail Zastrozhin ◽  
Marco Torrado ◽  
Elena Grishina ◽  
Kristina Ryzhikova ◽  
...  
Keyword(s):  
Steady State ◽  
Genetic Polymorphisms ◽  
Adverse Drug Reactions ◽  
Alcohol Withdrawal ◽  
Withdrawal Syndrome ◽  
Alcohol Withdrawal Syndrome ◽  
Efficacy And Safety ◽  
Drug Reactions ◽  
Steady State Concentration ◽  
State Concentration

Background: Diazepam is one of the most widely prescribed tranquilizers for the therapy of alcohol withdrawal syndrome (AWS), which includes the symptoms of anxiety, fear, and emotional tension. However, diazepam therapy often turns out to be ineffective, and some patients experience dose-dependent adverse drug reactions, reducing the efficacy of therapy. Aim: The purpose of our study was to investigate the effects of CYP2C19*17 genetic polymorphisms on the steady-state concentration of diazepam in patients with AWS. Materials and Methods: The study was conducted on 50 Russian male patients suffering from the AWS. For the therapy of psychomotor agitation, anxiety, fear, and emotional tension, patients received diazepam in injections at a dosage of 30.0 mg/day for 5 days. Genotyping was performed by real-time polymerase chain reaction. The efficacy and safety assessment was performed using psychometric scales and scales for assessing the severity of adverse drug reactions. Therapeutic drug monitoring (TDM) was performed using the high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS) method. Results: Based on the results of the study, we revealed the differences in the efficacy of therapy in patients with different CYP2C19 − 806C>T genotypes: (*1/*1) −12.0 [−15.0; −8.0], (*1/*17+*17/*17) −7.0 [−14.0; −5.0], P < .001, as well as the results of TDM: ( CC) 250.70 [213.34; 308.53] ng/mL (*1/*17+*17/*17) 89.12 [53.26; 178.07] ng/mL, P < .001. Conclusion: Thus, our study enrolling 50 patients with AWS, showed the effects of CYP2C19*17 genetic polymorphisms on the efficacy and safety rates of diazepam. Furthermore, we revealed the statistically significant difference in the levels of plasma steady-state concentrations of diazepam in patients carrying different genotypes.

scholarly journals Risperidone-induced adverse drug reactions and role of DRD2 (−141 C Ins/Del) and 5HTR2C (−759 C>T) genetic polymorphisms in patients with schizophrenia

2017 ◽  
Vol 8 (1) ◽  
pp. 28 ◽  
Author(s):  
DeepakGopal Shewade ◽  
CharanrajGoud Alladi ◽  
Anbarasan Mohan ◽  
RaviPhilip Rajkumar ◽  
Surendiran Adithan ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Adverse Drug Reactions ◽  
Drug Reactions

Alcohol use and potential risk for alcohol-related adverse drug reactions among community-based elderly

1993 ◽  
Vol 18 (4) ◽  
pp. 225-239 ◽  
Author(s):  
Lorna Earl Forster ◽  
Rachel Pollow ◽  
Eleanor Palo Stoller
Keyword(s):  
Alcohol Use ◽  
Adverse Drug Reactions ◽  
Potential Risk ◽  
Drug Reactions ◽  
Community Based
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