scholarly journals Antitumor effects of inductive hyperthermia using magnetic ferucarbotran nanoparticles on human lung cancer xenografts in nude mice

2013 ◽  
pp. 237 ◽  
Author(s):  
Tomoyuki Araya ◽  
Kasahara ◽  
Nishikawa ◽  
Kimura ◽  
Sone ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Nude Mice ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Antitumor Effects

miR-195-5p exerts tumor-suppressive functions in human lung cancer cells through targeting TrxR2

2020 ◽  
Author(s):  
Lina Bu ◽  
Yingxuan Tian ◽  
Hongqing Wen ◽  
Weihong Jia ◽  
Shuanying Yang
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Nude Mice ◽  
Human Lung ◽  
Cell Counting ◽  
Human Lung Cancer ◽  
Luciferase Reporter ◽  
Migration And Invasion ◽  
Antitumor Effects ◽  
Potential Biomarker

Abstract miR-195-5p has been widely explored in various cancers and is considered as a tumor-suppressive microRNA. However, its roles in human lung cancer pathogenesis are not fully elucidated. In this study, we aimed to explore how miR-195-5p is involved in malignant behaviors of lung adenocarcinoma (LUAD) cells. miR-195-5p expression was examined in the tumor tissues of patients with LUAD and human LUAD cell lines including A549 and PC-9. Thioredoxin reductase 2 (TrxR2) was predicted to be an mRNA target of miR-195-5p using online tools and validated by the Dual-Luciferase Reporter Assay. Lentivirus infection was used for gene overexpression, while gene knockdown was achieved by RNA interference. Cell proliferation was determined by Cell Counting Kit-8 and 5-ethynyl-2′-deoxyuridine methods, and cell migration and invasion were assayed with transwell experiments. Cell apoptosis was determined by annexin V staining-based flow cytometry. The antitumor effects of miR-195-5p were also evaluated in nude mice xenografted with A549 cells. We found that miR-195-5p was lowly expressed in human LUAD cells, and its overexpression markedly suppressed cell proliferation, migration, and invasion and increased the apoptosis of LUAD cells in vitro. TrxR2 knockdown phenocopied the tumor-suppressive effects of miR-195-5p overexpression, while simultaneous TrxR2 overexpression remarkably reversed the effects of miR-195-5p overexpression on malignant behaviors of A549 and PC-9 cells. Additionally, miR-195-5p overexpression inhibited the growth of xenografted A549 tumor in nude mice. Our work verified that miR-195-5p exerts tumor-suppressive functions in LUAD cells through targeting TrxR2 and suggested that the miR-195-5p/TrxR2 axis is a potential biomarker for LUAD therapy.

Quantitative analysis of distribution and fate of human lung cancer emboli labeled with 125I-5-iodo-2?-deoxyuridine in nude mice

Surgery Today ◽  
1993 ◽  
Vol 23 (11) ◽  
pp. 979-983 ◽  
Author(s):  
Kazuhiko Yoshida ◽  
Touru Fujikawa ◽  
Akihiro Tanabe ◽  
Kenji Sakurai
Keyword(s):  
Lung Cancer ◽  
Quantitative Analysis ◽  
Nude Mice ◽  
Human Lung ◽  
Human Lung Cancer

Treatment of human lung cancer-bearing nude mice with90Y-LC-l

2000 ◽  
Vol 12 (2) ◽  
pp. 155-156
Author(s):  
Si-jun Lin ◽  
Liang Zeng ◽  
Gao-ren Zhong ◽  
Zi-rui Ge
Keyword(s):  
Lung Cancer ◽  
Nude Mice ◽  
Human Lung ◽  
Human Lung Cancer

Human Lung Cancer Xenografts and Metastases in Athymic (Nude) Mice

2015 ◽  
pp. 277-280
Author(s):  
Adi F. Gazdar ◽  
Robert Shoemaker ◽  
Joseph Mayo ◽  
Herbert K. Oie ◽  
Patricia Donovan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Nude Mice ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Athymic Nude Mice

Ranpirnase enhances efficacy of radiation on A549 human lung cancer xenografts of nude mice assessed by diffuse optical spectroscopies

2006 ◽  
Author(s):  
Ula¸s Sunar ◽  
Chao Zhou ◽  
Turgut Durduran ◽  
Guoqiang Yu ◽  
Arjun G. Yodh ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Nude Mice ◽  
Human Lung ◽  
Human Lung Cancer

Distribution of radiolabelled monoclonal antibody Po66 after intravenous injection into nude mice bearing human lung cancer grafts

1989 ◽  
Vol 30 (5) ◽  
pp. 295-299 ◽  
Author(s):  
B. Desrues ◽  
B. Collet ◽  
M. P. Ramé ◽  
D. Bourel ◽  
P. Bourguet ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Monoclonal Antibody ◽  
Intravenous Injection ◽  
Nude Mice ◽  
Human Lung ◽  
Human Lung Cancer
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