scholarly journals End Processing Factor APLF Promotes NHEJ Efficiency and Contributes to TMZ- and Ionizing Radiation-Resistance in Glioblastoma Cells

2020 ◽  
Vol Volume 13 ◽  
pp. 10593-10605
Author(s):  
Wei Dong ◽  
Lanlan Li ◽  
Xuepeng Teng ◽  
Xinhua Yang ◽  
Shujing Si ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Radiation Resistance ◽  
Glioblastoma Cells ◽  
Processing Factor ◽  
Ionizing Radiation Resistance

scholarly journals Directed Evolution of Ionizing Radiation Resistance in Escherichia coli

2009 ◽  
Vol 191 (16) ◽  
pp. 5240-5252 ◽  
Author(s):  
Dennis R. Harris ◽  
Steve V. Pollock ◽  
Elizabeth A. Wood ◽  
Reece J. Goiffon ◽  
Audrey J. Klingele ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Ionizing Radiation ◽  
Directed Evolution ◽  
Radiation Resistance ◽  
Bacterial Species ◽  
Repair System ◽  
Multiple Alleles ◽  
Evolutionary Pathways ◽  
K 12 ◽  
Ionizing Radiation Resistance

ABSTRACT We have generated extreme ionizing radiation resistance in a relatively sensitive bacterial species, Escherichia coli, by directed evolution. Four populations of Escherichia coli K-12 were derived independently from strain MG1655, with each specifically adapted to survive exposure to high doses of ionizing radiation. D37 values for strains isolated from two of the populations approached that exhibited by Deinococcus radiodurans. Complete genomic sequencing was carried out on nine purified strains derived from these populations. Clear mutational patterns were observed that both pointed to key underlying mechanisms and guided further characterization of the strains. In these evolved populations, passive genomic protection is not in evidence. Instead, enhanced recombinational DNA repair makes a prominent but probably not exclusive contribution to genome reconstitution. Multiple genes, multiple alleles of some genes, multiple mechanisms, and multiple evolutionary pathways all play a role in the evolutionary acquisition of extreme radiation resistance. Several mutations in the recA gene and a deletion of the e14 prophage both demonstrably contribute to and partially explain the new phenotype. Mutations in additional components of the bacterial recombinational repair system and the replication restart primosome are also prominent, as are mutations in genes involved in cell division, protein turnover, and glutamate transport. At least some evolutionary pathways to extreme radiation resistance are constrained by the temporally ordered appearance of specific alleles.

Bacterial sensitivity to UV light as a model for ionizing radiation resistance

1993 ◽  
Vol 18 (2) ◽  
pp. 127-136 ◽  
Author(s):  
Andrew A. Arrange ◽  
Tommy J. Phelps ◽  
Robert E. Benoit ◽  
Anthony V. Palumbo ◽  
David C. White
Keyword(s):  
Ionizing Radiation ◽  
Radiation Resistance ◽  
Uv Light ◽  
Bacterial Sensitivity ◽  
Ionizing Radiation Resistance

scholarly journals A variant of the Escherichia coli anaerobic transcription factor FNR exhibiting diminished promoter activation function enhances ionizing radiation resistance

PLoS ONE ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. e0199482 ◽  
Author(s):  
Steven T. Bruckbauer ◽  
Joseph D. Trimarco ◽  
Camille Henry ◽  
Elizabeth A. Wood ◽  
John R. Battista ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Transcription Factor ◽  
Ionizing Radiation ◽  
Radiation Resistance ◽  
Activation Function ◽  
Promoter Activation ◽  
Ionizing Radiation Resistance

Low-Temperature Ionizing Radiation Resistance ofDeinococcus radioduransand Antarctic Dry Valley Bacteria

Astrobiology ◽  
2010 ◽  
Vol 10 (7) ◽  
pp. 717-732 ◽  
Author(s):  
Lewis R. Dartnell ◽  
Stephanie J. Hunter ◽  
Keith V. Lovell ◽  
Andrew J. Coates ◽  
John M. Ward
Keyword(s):  
Low Temperature ◽  
Ionizing Radiation ◽  
Radiation Resistance ◽  
Dry Valley ◽  
Ionizing Radiation Resistance

Role of Antioxidant Enzymes on Ionizing Radiation Resistance

1998 ◽  
Vol 24 (4) ◽  
pp. 586-593 ◽  
Author(s):  
Juan Sun ◽  
Yuan Chen ◽  
Mingtao Li ◽  
Zhongliang Ge
Keyword(s):  
Antioxidant Enzymes ◽  
Ionizing Radiation ◽  
Radiation Resistance ◽  
Ionizing Radiation Resistance

Genes required for ionizing radiation resistance in yeast

10.1038/ng778 ◽  
2001 ◽  
Vol 29 (4) ◽  
pp. 426-434 ◽  
Author(s):  
Craig B. Bennett ◽  
L. Kevin Lewis ◽  
Gopalakrishnan Karthikeyan ◽  
Kirill S. Lobachev ◽  
Yong H. Jin ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Radiation Resistance ◽  
Ionizing Radiation Resistance
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