scholarly journals Low-Temperature Plasma Suppresses Proliferation and Induces Apoptosis in Lung Cancer Cells by Regulating the miR-203a/BIRC5 Axis

2020 ◽  
Vol Volume 13 ◽  
pp. 5145-5153
Author(s):  
Yang Yang ◽  
Dan Li ◽  
Yulong Li ◽  
Qiuyu Jiang ◽  
Ruifang Sun ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Low Temperature ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Low Temperature Plasma ◽  
Temperature Plasma

scholarly journals Low temperature plasma irradiation products of sodium lactate solution that induce cell death on U251SP glioblastoma cells were identified

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hiromasa Tanaka ◽  
Yugo Hosoi ◽  
Kenji Ishikawa ◽  
Jun Yoshitake ◽  
Takahiro Shibata ◽  
...  
Keyword(s):  
Low Temperature ◽  
Cancer Cells ◽  
Sodium Lactate ◽  
Mass Spectrometry Analysis ◽  
Nuclear Magnetic Resonance Analysis ◽  
Low Temperature Plasma ◽  
Glioblastoma Cells ◽  
Temperature Plasma ◽  
Chemical Products ◽  
Lactate Solution

AbstractLow-temperature plasma is being widely used in the various fields of life science, such as medicine and agriculture. Plasma-activated solutions have been proposed as potential cancer therapeutic reagents. We previously reported that plasma-activated Ringer’s lactate solution exhibited selective cancer-killing effects, and that the plasma-treated L-sodium lactate in the solution was an anti-tumor factor; however, the components that are generated through the interactions between plasma and L-sodium lactate and the components responsible for the selective killing of cancer cells remain unidentified. In this study, we quantified several major chemical products, such as pyruvate, formate, and acetate, in plasma-activated L-sodium lactate solution by nuclear magnetic resonance analysis. We further identified novel chemical products, such as glyoxylate and 2,3-dimethyltartrate, in the solution by direct infusion-electrospray ionization with tandem mass spectrometry analysis. We found that 2,3-dimethyltartrate exhibited cytotoxic effects in glioblastoma cells, but not in normal astrocytes. These findings shed light on the identities of the components that are responsible for the selective cytotoxic effect of plasma-activated solutions on cancer cells, and provide useful data for the potential development of cancer treatments using plasma-activated L-sodium lactate solution.

Efficacy of Low Temperature Plasma against SCaBER Cancer Cells

2014 ◽  
Vol 11 (12) ◽  
pp. 1150-1155 ◽  
Author(s):  
Soheila Mohades ◽  
Nazir Barekzi ◽  
Mounir Laroussi
Keyword(s):  
Low Temperature ◽  
Cancer Cells ◽  
Low Temperature Plasma ◽  
Temperature Plasma
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