Effects of low temperature plasma on prostate cancer cells using the Bovie Medical J-Plasma® device

2016 ◽  
Vol 13 (12) ◽  
pp. 1189-1194 ◽  
Author(s):  
Nazir Barekzi ◽  
Mounir Laroussi ◽  
Greg Konesky ◽  
Shawn Roman
Keyword(s):  
Prostate Cancer ◽  
Low Temperature ◽  
Cancer Cells ◽  
Low Temperature Plasma ◽  
Prostate Cancer Cells ◽  
Temperature Plasma

scholarly journals Low Temperature Plasma: A Novel Focal Therapy for Localized Prostate Cancer?

2014 ◽  
Vol 2014 ◽  
pp. 1-15 ◽  
Author(s):  
Adam M. Hirst ◽  
Fiona M. Frame ◽  
Norman J. Maitland ◽  
Deborah O’Connell
Keyword(s):  
Prostate Cancer ◽  
Low Temperature ◽  
Focal Therapy ◽  
Localized Prostate Cancer ◽  
Low Temperature Plasma ◽  
Recurrence Rates ◽  
Novel Therapy ◽  
Temperature Plasma ◽  
Novel Approach ◽  
Wide Range

Despite considerable advances in recent years for the focal treatment of localized prostate cancer, high recurrence rates and detrimental side effects are still a cause for concern. In this review, we compare current focal therapies to a potentially novel approach for the treatment of early onset prostate cancer: low temperature plasma. The rapidly evolving plasma technology has the potential to deliver a wide range of promising medical applications via the delivery of plasma-induced reactive oxygen and nitrogen species. Studies assessing the effect of low temperature plasma on cell lines and xenografts have demonstrated DNA damage leading to apoptosis and reduction in cell viability. However, there have been no studies on prostate cancer, which is an obvious candidate for this novel therapy. We present here the potential of low temperature plasma as a focal therapy for prostate cancer.

scholarly journals Low-Temperature Plasma Suppresses Proliferation and Induces Apoptosis in Lung Cancer Cells by Regulating the miR-203a/BIRC5 Axis

2020 ◽  
Vol Volume 13 ◽  
pp. 5145-5153
Author(s):  
Yang Yang ◽  
Dan Li ◽  
Yulong Li ◽  
Qiuyu Jiang ◽  
Ruifang Sun ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Low Temperature ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Low Temperature Plasma ◽  
Temperature Plasma

scholarly journals Low temperature plasma irradiation products of sodium lactate solution that induce cell death on U251SP glioblastoma cells were identified

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hiromasa Tanaka ◽  
Yugo Hosoi ◽  
Kenji Ishikawa ◽  
Jun Yoshitake ◽  
Takahiro Shibata ◽  
...  
Keyword(s):  
Low Temperature ◽  
Cancer Cells ◽  
Sodium Lactate ◽  
Mass Spectrometry Analysis ◽  
Nuclear Magnetic Resonance Analysis ◽  
Low Temperature Plasma ◽  
Glioblastoma Cells ◽  
Temperature Plasma ◽  
Chemical Products ◽  
Lactate Solution

AbstractLow-temperature plasma is being widely used in the various fields of life science, such as medicine and agriculture. Plasma-activated solutions have been proposed as potential cancer therapeutic reagents. We previously reported that plasma-activated Ringer’s lactate solution exhibited selective cancer-killing effects, and that the plasma-treated L-sodium lactate in the solution was an anti-tumor factor; however, the components that are generated through the interactions between plasma and L-sodium lactate and the components responsible for the selective killing of cancer cells remain unidentified. In this study, we quantified several major chemical products, such as pyruvate, formate, and acetate, in plasma-activated L-sodium lactate solution by nuclear magnetic resonance analysis. We further identified novel chemical products, such as glyoxylate and 2,3-dimethyltartrate, in the solution by direct infusion-electrospray ionization with tandem mass spectrometry analysis. We found that 2,3-dimethyltartrate exhibited cytotoxic effects in glioblastoma cells, but not in normal astrocytes. These findings shed light on the identities of the components that are responsible for the selective cytotoxic effect of plasma-activated solutions on cancer cells, and provide useful data for the potential development of cancer treatments using plasma-activated L-sodium lactate solution.

Efficacy of Low Temperature Plasma against SCaBER Cancer Cells

2014 ◽  
Vol 11 (12) ◽  
pp. 1150-1155 ◽  
Author(s):  
Soheila Mohades ◽  
Nazir Barekzi ◽  
Mounir Laroussi
Keyword(s):  
Low Temperature ◽  
Cancer Cells ◽  
Low Temperature Plasma ◽  
Temperature Plasma

279: Inhibition of Cyclooxygenase-2 Pathway Overcomes the Heat-Resistance in Prostate Cancer Cells

2007 ◽  
Vol 177 (4S) ◽  
pp. 93-93
Author(s):  
Makoto Sumitomo ◽  
Kenji Kuroda ◽  
Takako Asano ◽  
Akio Horiguchi ◽  
Keiichi Ito ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Heat Resistance ◽  
Cancer Cells ◽  
Cyclooxygenase 2 ◽  
Prostate Cancer Cells
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