scholarly journals Silencing circZFR inhibits the proliferation, migration and invasion of human renal carcinoma cells by regulating miR-206

2019 ◽  
Vol Volume 12 ◽  
pp. 7537-7550 ◽  
Author(s):  
Mi Wang ◽  
Yisheng Gao ◽  
Jie Liu
Keyword(s):  
Renal Carcinoma ◽  
Carcinoma Cells ◽  
Migration And Invasion ◽  
Human Renal Carcinoma ◽  
Renal Carcinoma Cells

scholarly journals Alpha-Mangostin Suppresses the Metastasis of Human Renal Carcinoma Cells by Targeting MEK/ERK Expression and MMP-9 Transcription Activity

2017 ◽  
Vol 44 (4) ◽  
pp. 1460-1470 ◽  
Author(s):  
Chien-Min Chen ◽  
Shu-Ching Hsieh ◽  
Chia-Liang Lin ◽  
Yu-Syun Lin ◽  
Jen-Pi Tsai ◽  
...  
Keyword(s):  
Cell Migration ◽  
Renal Carcinoma ◽  
Carcinoma Cells ◽  
Luciferase Assay ◽  
Migration And Invasion ◽  
Mrna Levels ◽  
Dependent Manner ◽  
Cell Migration And Invasion ◽  
Human Renal Carcinoma ◽  
Renal Carcinoma Cells

Background/Aims: α-mangostin has anti-carcinogenic effects against several cancers. We investigated the molecular mechanism of this compound on the metastasis of human renal carcinoma cells. Methods: Cell viability was measured using the MTT assay, and cell cycle distribution using flow cytometry. A Matrigel-based assay was used to measure in vitro cell migration and invasion. MAPK-related proteins and matrix metalloproteinase (MMP)-9 and MMP-2 expression were measured by western blotting, and MMP2/-9 activities were determined by gelatin zymography. RT-qPCR and a luciferase assay were used to examine the transcriptional activity of MMP-9. Results: α-mangostin inhibited the migration and invasion of RCC cells in a dose-dependent manner, but had no evident cytotoxic effects. Treatment of 786-O cells with α-mangostin inhibited activation of MEK and ERK. Treatment with a specific MEK inhibitor (U0126) enhanced the inhibitory effects of α-mangostin on cell migration and invasion, and the phosphorylation of ERK and MEK. Moreover, α-mangostin inhibited the expression of the MMP-9 mRNA levels as well as the activity of MMP-9 promoter, and these suppressive effects were further enhanced by U0126. Conclusions: Our results suggest that α-mangostin suppresses cell migration and invasion via MEK/ERK/MMP9 pathway, and might be a promising anti-metastatic agent against human renal cell carcinoma.

scholarly journals Immune Check Point CD40–CD40L Activates Dendritic and Effector Cells Against Human Renal Carcinoma Cells

2019 ◽  
Vol 39 (9) ◽  
pp. 4643-4652 ◽  
Author(s):  
REGINA M. HILLEBRAND ◽  
ANNABELLE VOGT ◽  
CHRISTIAN P. STRASSBURG ◽  
MARIA A. GONZALEZ-CARMONA ◽  
INGO G.H. SCHMIDT-WOLF
Keyword(s):  
Renal Carcinoma ◽  
Carcinoma Cells ◽  
Check Point ◽  
Effector Cells ◽  
Human Renal Carcinoma ◽  
Renal Carcinoma Cells

Endoplasmic reticulum stress mediates withaferin A-induced apoptosis in human renal carcinoma cells

2011 ◽  
Vol 25 (3) ◽  
pp. 692-698 ◽  
Author(s):  
Min Jung Choi ◽  
Eun Jung Park ◽  
Kyoung Jin Min ◽  
Jong-Wook Park ◽  
Taeg Kyu Kwon
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Renal Carcinoma ◽  
Carcinoma Cells ◽  
Withaferin A ◽  
Induced Apoptosis ◽  
Human Renal Carcinoma ◽  
Renal Carcinoma Cells

Anti-Ki-67 peptide nucleic acid affects the proliferation and apoptosis of human renal carcinoma cells in vitro

Life Sciences ◽  
2005 ◽  
Vol 76 (16) ◽  
pp. 1873-1881 ◽  
Author(s):  
Jun-Nian Zheng ◽  
Ya-Feng Sun ◽  
Dong-Sheng Pei ◽  
Jun-Jie Liu ◽  
Xiao-Qing Sun ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Renal Carcinoma ◽  
Carcinoma Cells ◽  
Ki 67 ◽  
Proliferation And Apoptosis ◽  
Human Renal Carcinoma ◽  
Renal Carcinoma Cells
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