scholarly journals MYO5A inhibition by miR-145 acts as a predictive marker of occult neck lymph node metastasis in human laryngeal squamous cell carcinoma

2018 ◽  
Vol Volume 11 ◽  
pp. 3619-3635 ◽  
Author(s):  
Xudong Zhao ◽  
Wei Zhang ◽  
Wenyue Ji
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Predictive Marker ◽  
Neck Lymph Node ◽  
Node Metastasis ◽  
Neck Lymph Node Metastasis

Xeroderma pigmentosum: neck lymph node metastasis of a squamous cell carcinoma of the skin treated with cetuximab

2009 ◽  
Vol 19 (2) ◽  
pp. 163-165 ◽  
Author(s):  
Jordi Rubió Casadevall ◽  
Begoña Graña-Suárez ◽  
Xavier Hernandez-Yagüe ◽  
Jordi Vayreda Ribera ◽  
Oscar Huc Grasa ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Xeroderma Pigmentosum ◽  
Neck Lymph Node ◽  
Node Metastasis ◽  
Neck Lymph Node Metastasis

Clinical predictors for contralateral neck lymph node metastasis from unilateral squamous cell carcinoma in the oral cavity

Oral Oncology ◽  
2004 ◽  
Vol 40 (9) ◽  
pp. 898-903 ◽  
Author(s):  
Hiroshi Kurita ◽  
Takeshi Koike ◽  
Jun-nosuke Narikawa ◽  
Hironori Sakai ◽  
Atsushi Nakatsuka ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Predictors ◽  
Neck Lymph Node ◽  
Node Metastasis ◽  
Neck Lymph Node Metastasis

scholarly journals Peri-tumoral Lymphovascular density by antipodoplanin antibody D2-40, as a predictor of nodal metastasis in oral squamous cell carcinoma

The Physician ◽  
2020 ◽  
Vol 6 (3) ◽  
pp. 1-11
Author(s):  
Kunwar Parvez ◽  
Vipin Arora ◽  
Neelam Wadhwa
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Site ◽  
Neck Lymph Node ◽  
Node Metastasis ◽  
Neck Lymph Node Metastasis

BACKGROUND: The involvement of regional lymph nodes by cancer is a major determinant of prognosis in oral squamous cell carcinoma (OSCC) and is a significant predictor of patient survival. Peri-tumoral lymphangiogenesis is being studied as an important tool in predicting neck lymph node metastasis. Podoplanin, a transmembrane glycoprotein is expressed on lymphatic vessel endothelium and considered as a marker of lymphangiogenesis.  The high podoplanin expression has been associated with invasion, progression, and metastasis of oral cancer. D2-40, an anti-podoplanin monoclonal antibody, is a specific marker of lymphatic endothelial cells. The present study was designed to investigate the peritumoral lymphovascular density (PT-LVD) by evaluating D2-40 expression and its potential utility in predicting lymph node metastasis in OSCC. METHODS: Seventy-two patients with OSCC were enrolled (36 with early and 36 with advanced-stage tumors). Differential expression of peritumoral lymphovascular density (PT-LVD) was evaluated using D2-40 expression by immunohistochemistry (IHC). Expression was categorized as low and high, derived from the mean of a number of vessels per 10 high power fields in hot-spots. Statistical methods were employed to correlate expression with age, gender, tumor site, stage, and neck lymph node involvement.  RESULTS: We observed a significant association between peritumoral lymphovascular density (PT-LVD) with clinical neck lymph node status (p=0.001) and tumor stage (p=0.033).  There was no significant correlation of D2-40 expression with age, gender, tumor site, T stage, and tumor differentiation. CONCLUSION:  PT-LVD is a positive predictor of neck lymph node metastasis. It has translational potential, along with other clinical parameters for decision making in the treatment of the neck in oral cancer.

STC2: A Predictive Marker for Lymph Node Metastasis in Esophageal Squamous-Cell Carcinoma

2010 ◽  
Vol 18 (1) ◽  
pp. 261-272 ◽  
Author(s):  
Yoshiaki Kita ◽  
Koshi Mimori ◽  
Masaaki Iwatsuki ◽  
Takehiko Yokobori ◽  
Keisuke Ieta ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Predictive Marker ◽  
Node Metastasis
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