scholarly journals miR-99a-5p acts as tumor suppressor via targeting to mTOR and enhances RAD001-induced apoptosis in human urinary bladder urothelial carcinoma cells

2018 ◽  
Vol Volume 11 ◽  
pp. 239-252 ◽  
Author(s):  
Te-Fu Tsai ◽  
Ji-Fan Lin ◽  
Kuang-Yu Chou ◽  
Yi-Chia Lin ◽  
Hung-En Chen ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Carcinoma Cells ◽  
Human Urinary Bladder ◽  
Bladder Urothelial Carcinoma ◽  
Induced Apoptosis

Ganoderma microsporum immunomodulatory protein induces apoptosis and potentiates mitomycin C-induced apoptosis in urinary bladder urothelial carcinoma cells

2018 ◽  
Vol 119 (6) ◽  
pp. 4592-4606 ◽  
Author(s):  
Sheng-Yuan Huang ◽  
Chih-Cheng Chien ◽  
Ruey-Shyang Hseu ◽  
Victoria Ying Jen Huang ◽  
Shang Ying Chiang ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Mitomycin C ◽  
Carcinoma Cells ◽  
Bladder Urothelial Carcinoma ◽  
Immunomodulatory Protein ◽  
Induced Apoptosis

EMP2 induces cytostasis and apoptosis via the TGFβ/SMAD/SP1 axis and recruitment of P2RX7 in urinary bladder urothelial carcinoma

2021 ◽  
Author(s):  
Chien-Feng Li ◽  
Ti-Chun Chan ◽  
Cheng-Tang Pan ◽  
Pichpisith Pierre Vejvisithsakul ◽  
Jia-Chen Lai ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Bladder Urothelial Carcinoma

scholarly journals The inhibitory effect of silencing CDCA3 on migration and proliferation in bladder urothelial carcinoma

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dexin Shen ◽  
Yayun Fang ◽  
Fenfang Zhou ◽  
Zhao Deng ◽  
Kaiyu Qian ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Urothelial Carcinoma ◽  
Carcinoma Cells ◽  
Expression Level ◽  
Tumor Cell Growth ◽  
Migration Ability ◽  
Bladder Urothelial Carcinoma ◽  
Related Proteins

Abstract Background CDCA3 is an important component of the E3 ligase complex with SKP1 and CUL1, which could regulate the progress of cell mitosis. CDCA3 has been widely identified as a proto-oncogene in multiple human cancers, however, its role in promoting human bladder urothelial carcinoma has not been fully elucidated. Methods Bioinformatic methods were used to analyze the expression level of CDCA3 in human bladder urothelial carcinoma tissues and the relationship between its expression level and key clinical characteristics. In vitro studies were performed to validate the specific functions of CDCA3 in regulating cell proliferation, cell migration and cell cycle process. Alterations of related proteins was investigated by western blot assays. In vivo studies were constructed to validate whether silencing CDCA3 could inhibit the proliferation rate in mice model. Results Bioinformatic analysis revealed that CDCA3 was significantly up-regulated in bladder urothelial carcinoma samples and was related to key clinical characteristics, such as tumor grade and metastasis. Moreover, patients who had higher expression level of CDCA3 tend to show a shorter life span. In vitro studies revealed that silencing CDCA3 could impair the migration ability of tumor cells via down-regulating EMT-related proteins such as MMP9 and Vimentin and inhibit tumor cell growth via arresting cells in the G1 cell cycle phase through regulating cell cycle related proteins like p21. In vivo study confirmed that silencing CDCA3 could inhibit the proliferation of bladder urothelial carcinoma cells. Conclusions CDCA3 is an important oncogene that could strengthen the migration ability of bladder urothelial carcinoma cells and accelerate tumor cell growth via regulating cell cycle progress and is a potential biomarker of bladder urothelial carcinoma.

scholarly journals A Case of Urinary Bladder Urothelial Carcinoma with Squamous, Glandular, and Plasmacytoid Differentiation

2014 ◽  
Vol 7 (2) ◽  
pp. 362-368 ◽  
Author(s):  
Naohiro Makise ◽  
Teppei Morikawa ◽  
Yuta Takeshima ◽  
Yukio Homma ◽  
Masashi Fukayama
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Bladder Urothelial Carcinoma

scholarly journals Alterations of Chromatin Regulators in the Pathogenesis of Urinary Bladder Urothelial Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 6040
Author(s):  
Michèle J. Hoffmann ◽  
Wolfgang A. Schulz
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Checkpoint Control ◽  
Genetic Changes ◽  
Genomic Changes ◽  
Chromatin Regulators ◽  
Chromatin Remodeling Complex ◽  
Bladder Urothelial Carcinoma ◽  
Histone Modifying Enzymes ◽  
Gene Expression Alterations

Urothelial carcinoma (UC) is the most frequent histological type of cancer in the urinary bladder. Genomic changes in UC activate MAPK and PI3K/AKT signal transduction pathways, which increase cell proliferation and survival, interfere with cell cycle and checkpoint control, and prevent senescence. A more recently discovered additional category of genetic changes in UC affects chromatin regulators, including histone-modifying enzymes (KMT2C, KMT2D, KDM6A, EZH2), transcription cofactors (CREBBP, EP300), and components of the chromatin remodeling complex SWI/SNF (ARID1A, SMARCA4). It is not yet well understood how these changes contribute to the development and progression of UC. Therefore, we review here the emerging knowledge on genomic and gene expression alterations of chromatin regulators and their consequences for cell differentiation, cellular plasticity, and clonal expansion during UC pathogenesis. Our analysis identifies additional relevant chromatin regulators and suggests a model for urothelial carcinogenesis as a basis for further mechanistic studies and targeted therapy development.

scholarly journals Galactin-1 Dysregulation is Predict Factor to Prognosis of Urinary Bladder Urothelial Carcinoma

2015 ◽  
Vol 26 (2) ◽  
pp. S13
Author(s):  
Kun-Lin Hsieh ◽  
Chi-Cheng Su ◽  
Kun-Hung Shen ◽  
Ting-Feng Wu
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Bladder Urothelial Carcinoma

Diagnosis of urinary bladder urothelial carcinoma by immunocytology with p53, MCM 5, MCM 2 and Ki‐67 antibodies using cell blocks derived from urine

Cytopathology ◽  
2019 ◽  
Vol 30 (5) ◽  
pp. 510-518
Author(s):  
Antonín Brisuda ◽  
Jaromír Háček ◽  
Marcela Čechová ◽  
Petr Škapa ◽  
Marek Babjuk
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Ki 67 ◽  
Bladder Urothelial Carcinoma
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