scholarly journals The cAMP responsive element binding protein 1 transactivates epithelial membrane protein 2, a potential tumor suppressor in the urinary bladder urothelial carcinoma

Oncotarget ◽  
2015 ◽  
Vol 6 (11) ◽  
pp. 9220-9239 ◽  
Author(s):  
Chien-Feng Li ◽  
Wen-Jeng Wu ◽  
Wen-Ren Wu ◽  
Yu-Jing Liao ◽  
Lih-Ren Chen ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Urinary Bladder ◽  
Membrane Protein ◽  
Urothelial Carcinoma ◽  
Bladder Urothelial Carcinoma ◽  
Element Binding Protein ◽  
Responsive Element ◽  
Epithelial Membrane Protein 2 ◽  
Camp Responsive Element Binding ◽  
Potential Tumor Suppressor

EMP2 induces cytostasis and apoptosis via the TGFβ/SMAD/SP1 axis and recruitment of P2RX7 in urinary bladder urothelial carcinoma

2021 ◽  
Author(s):  
Chien-Feng Li ◽  
Ti-Chun Chan ◽  
Cheng-Tang Pan ◽  
Pichpisith Pierre Vejvisithsakul ◽  
Jia-Chen Lai ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Bladder Urothelial Carcinoma

scholarly journals Acetylation of cAMP-responsive Element-binding Protein (CREB) by CREB-binding Protein Enhances CREB-dependent Transcription

2003 ◽  
Vol 278 (18) ◽  
pp. 15727-15734 ◽  
Author(s):  
Qing Lu ◽  
Amanda E. Hutchins ◽  
Colleen M. Doyle ◽  
James R. Lundblad ◽  
Roland P. S. Kwok
Keyword(s):  
Binding Protein ◽  
Creb Binding Protein ◽  
Element Binding Protein ◽  
Responsive Element ◽  
Camp Responsive Element Binding

scholarly journals A Case of Urinary Bladder Urothelial Carcinoma with Squamous, Glandular, and Plasmacytoid Differentiation

2014 ◽  
Vol 7 (2) ◽  
pp. 362-368 ◽  
Author(s):  
Naohiro Makise ◽  
Teppei Morikawa ◽  
Yuta Takeshima ◽  
Yukio Homma ◽  
Masashi Fukayama
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Bladder Urothelial Carcinoma

scholarly journals Alterations of Chromatin Regulators in the Pathogenesis of Urinary Bladder Urothelial Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 6040
Author(s):  
Michèle J. Hoffmann ◽  
Wolfgang A. Schulz
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Checkpoint Control ◽  
Genetic Changes ◽  
Genomic Changes ◽  
Chromatin Regulators ◽  
Chromatin Remodeling Complex ◽  
Bladder Urothelial Carcinoma ◽  
Histone Modifying Enzymes ◽  
Gene Expression Alterations

Urothelial carcinoma (UC) is the most frequent histological type of cancer in the urinary bladder. Genomic changes in UC activate MAPK and PI3K/AKT signal transduction pathways, which increase cell proliferation and survival, interfere with cell cycle and checkpoint control, and prevent senescence. A more recently discovered additional category of genetic changes in UC affects chromatin regulators, including histone-modifying enzymes (KMT2C, KMT2D, KDM6A, EZH2), transcription cofactors (CREBBP, EP300), and components of the chromatin remodeling complex SWI/SNF (ARID1A, SMARCA4). It is not yet well understood how these changes contribute to the development and progression of UC. Therefore, we review here the emerging knowledge on genomic and gene expression alterations of chromatin regulators and their consequences for cell differentiation, cellular plasticity, and clonal expansion during UC pathogenesis. Our analysis identifies additional relevant chromatin regulators and suggests a model for urothelial carcinogenesis as a basis for further mechanistic studies and targeted therapy development.

Sign in / Sign up

Export Citation Format

Share Document