scholarly journals Ultra-Widefield Fluorescein Angiographic Patterns, Retinal Microvascular Anomalies and Retinal Ischemic Index in Branch Retinal Vein Occlusions with Established Retinal Neovascularization

2020 ◽  
Vol Volume 14 ◽  
pp. 2965-2974
Author(s):  
Peck Lin Lip ◽  
Hemalatha Kolli ◽  
Dipti Trivedi
Keyword(s):  
Retinal Neovascularization ◽  
Retinal Vein Occlusions ◽  
Fluorescein Angiographic

Features of chorioretinal hemodynamics with retinal vein occlusions in young women

2020 ◽  
pp. 46-47
Author(s):  
A.A. Fil ◽  
◽  
E.L. Sorokin ◽  
O.V. Kolenko ◽  
◽  
...  
Keyword(s):  
Young Women ◽  
Retinal Vein Occlusions

Актуальность. В структуре сосудистой патологии глаза в последние годы отмечается неуклонное повышение частоты окклюзий ретинальных вен (ОРВ), преимущественно у женщин молодого возраста. Цель. Исследовать особенности хориоретинальной гемодинамики при ОРВ у женщин молодого возраста. Материал и методы. Отобрано 15 женщин (15 глаз) с ОРВ в возрасте от 35 до 45 лет (39,7±4 года). Группа контроля была сформирована 20 соматически здоровыми женщинами сопоставимого возраста. Изучались показатели линейной скорости кровотока в задних коротких цилиарных артериях: максимальная систолическая скорость (Vmax, см/с), конечная диастолическая скорость (Vmin, см/с), средняя скорость (Vmed, см/с), индекс резистентности или периферического сопротивления (RI), пульсационный индекс (PI). Исследовались показатели макулярного кровотока: общая средняя плотность поверхностного сосудистого сплетения (ОПС, %), площадь аваскулярной зоны сетчатки (ПАЗ, мм2), субфовеолярная толщина хориоидеи (СТХ, мкм). Результаты. В основной группе показатели Vmax, Vmin, Vmed, PI, RI оказались статистически значимо ниже группы контроля, составив: 8,29±0,64 см/с, 2,64±0,24 см/с, 4,52±0,35 см/с; 1,245±0,06 и 0,68±0,02 против: 13,32±0,64 см/с, 5,02±0,70 см/с, 7,92±0,74 см/с; 1,022±0,06 и 0,62±0,03 соответственно (р<0,001). Выявлены также и характерные изменения показателей макулярного кровотока: ОПС и СТХ оказались статистически значимо ниже по сравнению с контрольной группой – 44,47±3,08 % и 248±7 мкм против 54,73±2,4 % и 285±18 мкм соответственно (p<0,001). При этом в основной группе отмечалось увеличение площади аваскулярной зоны: ПАЗ – 0,366±0,020 мм2 против 0,267±0,097 мм2 в контроле соответственно (p=0,007). В основной группе ОРВ клинически проявлялись формированием зон капиллярной неперфузии, интраретинальных геморрагий, «ватообразных» экссудатов по ходу пораженной сосудистой аркады, увеличением площади аваскулярной зоны. Выводы. Выявленные статистически значимые снижения показателей хориоретинальной гемодинамики и клинические проявления ОРВ у женщин молодого возраста свидетельствуют о склонности их развития, преимущественно по ишемическому типу.

scholarly journals Peripheral Retinal Neovascularization with Vitreous Hemorrhage in HIV Retinopathy

2017 ◽  
Vol 8 (2) ◽  
pp. 353-357 ◽  
Author(s):  
Kim Jiramongkolchai ◽  
Tin Yan Alvin Liu ◽  
J. Fernando Arevalo
Keyword(s):  
African American ◽  
Laser Photocoagulation ◽  
African American Woman ◽  
American Woman ◽  
Vitreous Hemorrhage ◽  
Retinal Ischemia ◽  
Retinal Neovascularization ◽  
Clinical Spectrum

We report a case of peripheral retinal neovascularization and vitreous hemorrhage in the setting of HIV retinopathy that can serve to extend the clinical spectrum of this condition. A 53-year-old African-American woman with AIDS was referred for decreased vision in the left eye and was found to have peripheral retinal neovascularization and vitreous hemorrhage. She had a workup that was negative for etiologies of retinal ischemia. Peripheral laser photocoagulation was used to treat areas of nonperfusion. To our knowledge, this is the first reported case of peripheral retinal neovascularization and vitreous hemorrhage in the setting of HIV retinopathy, and it can serve to extend the clinical spectrum of this condition.

scholarly journals VEGF164-mediated Inflammation Is Required for Pathological, but Not Physiological, Ischemia-induced Retinal Neovascularization

2003 ◽  
Vol 198 (3) ◽  
pp. 483-489 ◽  
Author(s):  
Susumu Ishida ◽  
Tomohiko Usui ◽  
Kenji Yamashiro ◽  
Yuichi Kaji ◽  
Shiro Amano ◽  
...  
Keyword(s):  
Immune Responses ◽  
Leukocyte Adhesion ◽  
Leading Edge ◽  
Retinal Neovascularization ◽  
Wild Type ◽  
Therapeutic Approaches ◽  
Contrast Administration ◽  
New Therapeutic Approaches ◽  
Targeted Inactivation ◽  
Vegf Isoforms

Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological retinal neovascularization. In the current paper, the mechanisms of physiological and pathological neovascularization are compared and contrasted. During pathological neovascularization, both the absolute and relative expression levels for VEGF164 increased to a greater degree than during physiological neovascularization. Furthermore, extensive leukocyte adhesion was observed at the leading edge of pathological, but not physiological, neovascularization. When a VEGF164-specific neutralizing aptamer was administered, it potently suppressed the leukocyte adhesion and pathological neovascularization, whereas it had little or no effect on physiological neovascularization. In parallel experiments, genetically altered VEGF164-deficient (VEGF120/188) mice exhibited no difference in physiological neovascularization when compared with wild-type (VEGF+/+) controls. In contrast, administration of a VEGFR-1/Fc fusion protein, which blocks all VEGF isoforms, led to significant suppression of both pathological and physiological neovascularization. In addition, the targeted inactivation of monocyte lineage cells with clodronate-liposomes led to the suppression of pathological neovascularization. Conversely, the blockade of T lymphocyte–mediated immune responses with an anti-CD2 antibody exacerbated pathological neovascularization. These data highlight important molecular and cellular differences between physiological and pathological retinal neovascularization. During pathological neovascularization, VEGF164 selectively induces inflammation and cellular immunity. These processes provide positive and negative angiogenic regulation, respectively. Together, new therapeutic approaches for selectively targeting pathological, but not physiological, retinal neovascularization are outlined.

Retinal obliterative vasculitis associated to contralateral retinal neovascularization in membranoproliferative glomerulonephritis

2021 ◽  
pp. 112067212110143
Author(s):  
Michele Nicolai ◽  
Alessandro Franceschi ◽  
Nicola Vito Lassandro ◽  
Paolo Pelliccioni ◽  
Luca Danieli ◽  
...  
Keyword(s):  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Membranoproliferative Glomerulonephritis ◽  
Vision Loss ◽  
Vascular Occlusion ◽  
Retinal Neovascularization ◽  
Vein Occlusion ◽  
Retinal Vascular Occlusion ◽  
Contralateral Eye ◽  
Peculiar Case

Purpose: To report our experience with a peculiar case of asynchronous bilateral retinal vascular occlusion in a patient suffering from membranoproliferative glomerulonephritis. Case report: A 57-year-old dialysed male affected by membranoproliferative glomerulonephritis who underwent kidney transplantation complained of a sudden vision loss in his right eye (RE). His best-corrected visual acuity (BCVA) was 20/40 in RE and 20/20 in the left eye (LE); ophthalmological and fluorangiographic examinations revealed unilateral retinal obliterative vasculitis with panuveitis and apparent sparing of contralateral eye. About 6 months later the patient developed a branch retinal vein occlusion associated with a papillary neovascular membrane in LE. Corticosteroid therapy was administered and immunosuppressant dosage was increased with macular oedema reduction in both events. Conclusion: We report a case of unilateral retinal obliterative vasculitis and subsequent contralateral retinal neovascularization and branch retinal vein occlusion in a patient affected by membranoproliferative glomerulonephritis.

Corneal Coloboma, Aphakia and Retinal Neovascularization with Anterior Segment Dysgenesis (Peters’ Anomaly)

1996 ◽  
Vol 210 (6) ◽  
pp. 361-366 ◽  
Author(s):  
Charlise A. Gunderson ◽  
Robert Stone ◽  
Robert Peiffer ◽  
Sharon Freedman
Keyword(s):  
Anterior Segment ◽  
Retinal Neovascularization ◽  
Anterior Segment Dysgenesis ◽  
Peters Anomaly

Experimental Central Serous Chorioretinopathy in Monkey Eyes: Fluorescein Angiographic Findings

1982 ◽  
Vol 185 (3) ◽  
pp. 168-178 ◽  
Author(s):  
Hisaharu Yoshioka ◽  
Yasuhiro Katsume ◽  
Hideki Akune
Keyword(s):  
Central Serous Chorioretinopathy ◽  
Angiographic Findings ◽  
Fluorescein Angiographic

Pigment Epithelium-Derived Factor Inhibits Oxygen-Induced Retinal Neovascularization in a Murine Model

2016 ◽  
Vol 35 (3) ◽  
pp. 173-185 ◽  
Author(s):  
Shulian Zhang ◽  
Guanpeng Zhai ◽  
Wenjing Shi ◽  
Yuhuan Wang ◽  
Li Zhu ◽  
...  
Keyword(s):  
Murine Model ◽  
Pigment Epithelium ◽  
Retinal Neovascularization ◽  
Pigment Epithelium Derived Factor
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