Retinal Ischemia (Capillary Nonperfusion) and Retinal Neovascularization in Patients with Diabetic Retinopathy

1978 ◽  
Vol 177 (3) ◽  
pp. 140-145 ◽  
Author(s):  
S. Merin ◽  
I. Ber ◽  
M. Ivry
Keyword(s):  
Diabetic Retinopathy ◽  
Retinal Ischemia ◽  
Retinal Neovascularization

scholarly journals Increased Vitreous Concentrations of Human Hepatocyte Growth Factor in Proliferative Diabetic Retinopathy1

1999 ◽  
Vol 84 (2) ◽  
pp. 659-662
Author(s):  
Masato Nishimura ◽  
Tsunehiko Ikeda ◽  
Masaji Ushiyama ◽  
Akira Nanbu ◽  
Shigeru Kinoshita ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Growth Factor ◽  
Proliferative Vitreoretinopathy ◽  
Retinal Ischemia ◽  
Human Hepatocyte ◽  
Retinal Neovascularization ◽  
Nondiabetic Control ◽  
Human Hepatocyte Growth Factor ◽  
The Mean ◽  
Hepatocyte Growth

Human hepatocyte GF (hHGF) has strong neoangiogenesis activity. The present study was designed to investigate the possible involvement of hHGF in neovascularization in proliferative diabetic retinopathy (PDR) by measuring vitreous hHGF concentrations. The mean vitreous hHGF concentration was higher in subjects with PDR (5.70 ± 0.68 ng/mL, n = 33) than in nondiabetic control subjects (1.50 ± 0.20 ng/mL, n = 18, P < 0.01), nondiabetic subjects with proliferative vitreoretinopathy (3.31 ± 0.57 ng//mL, n = 10, P < 0.05), or diabetic subjects without PDR (1.29 ± 0.28 ng/mL, n = 8, P < 0.01). PDR subjects with neovascularization of iris, which suggests advanced retinal ischemia, showed a higher mean vitreous hHGF concentration than those without iridal neovascularization [7.33 ± 1.16 ng/mL (n = 14) vs. 4.49 ± 0.72 ng/mL (n = 19), P < 0.05]. The mean vitreous hHGF concentration was higher in PDR subjects with retinal neovascularization at the optic disc than in those with neovascularization elsewhere [7.3 ± 1.1 ng/mL (n = 15) vs. 4.4 ± 0.7 ng/mL (n = 18), P < 0.05]. Our results indicate that vitreous hHGF may play a role in retinal neovascularization in PDR.

scholarly journals Peripheral Retinal Neovascularization with Vitreous Hemorrhage in HIV Retinopathy

2017 ◽  
Vol 8 (2) ◽  
pp. 353-357 ◽  
Author(s):  
Kim Jiramongkolchai ◽  
Tin Yan Alvin Liu ◽  
J. Fernando Arevalo
Keyword(s):  
African American ◽  
Laser Photocoagulation ◽  
African American Woman ◽  
American Woman ◽  
Vitreous Hemorrhage ◽  
Retinal Ischemia ◽  
Retinal Neovascularization ◽  
Clinical Spectrum

We report a case of peripheral retinal neovascularization and vitreous hemorrhage in the setting of HIV retinopathy that can serve to extend the clinical spectrum of this condition. A 53-year-old African-American woman with AIDS was referred for decreased vision in the left eye and was found to have peripheral retinal neovascularization and vitreous hemorrhage. She had a workup that was negative for etiologies of retinal ischemia. Peripheral laser photocoagulation was used to treat areas of nonperfusion. To our knowledge, this is the first reported case of peripheral retinal neovascularization and vitreous hemorrhage in the setting of HIV retinopathy, and it can serve to extend the clinical spectrum of this condition.

Tetrahedral framework nucleic acids prevent retina ischemia-reperfusion injury from oxidative stress via activating the Akt/Nrf2 pathway

Nanoscale ◽  
2019 ◽  
Vol 11 (43) ◽  
pp. 20667-20675 ◽  
Author(s):  
Xin Qin ◽  
Ni Li ◽  
Mei Zhang ◽  
Shiyu Lin ◽  
Junyao Zhu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Arterial Occlusion ◽  
Retinal Ischemia ◽  
Tetrahedral Framework ◽  
Nrf2 Pathway ◽  
Retinal Arterial Occlusion ◽  
Ophthalmic Diseases

Retinal ischemia-reperfusion (I/R) injuries are involved in the universal pathological processes of many ophthalmic diseases, including glaucoma, diabetic retinopathy, and retinal arterial occlusion.

Foveal Retinal Neovascularization in Proliferative Diabetic Retinopathy

Retina ◽  
2017 ◽  
Vol 37 (11) ◽  
pp. e135-e137 ◽  
Author(s):  
Sakura Murakawa ◽  
Taiji Hasegawa ◽  
Hideki Koizumi ◽  
Ichiro Maruko ◽  
Tomohiro Iida
Keyword(s):  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Retinal Neovascularization

scholarly journals MicroRNA-409-5p promotes retinal neovascularization in diabetic retinopathy

Cell Cycle ◽  
2020 ◽  
Vol 19 (11) ◽  
pp. 1314-1325
Author(s):  
Ying Wang ◽  
Wenwen Lin ◽  
Jianghua Ju
Keyword(s):  
Diabetic Retinopathy ◽  
Retinal Neovascularization

Anti-Flt1 peptide – Hyaluronate conjugate for the treatment of retinal neovascularization and diabetic retinopathy

Biomaterials ◽  
2011 ◽  
Vol 32 (11) ◽  
pp. 3115-3123 ◽  
Author(s):  
Eun Ju Oh ◽  
Jun-Sub Choi ◽  
Hyemin Kim ◽  
Choun-Ki Joo ◽  
Sei Kwang Hahn
Keyword(s):  
Diabetic Retinopathy ◽  
Retinal Neovascularization

scholarly journals Optical Coherence Tomography Features Of Active And Inactive Retinal Neovascularization In Proliferative Diabetic Retinopathy

Retina ◽  
2016 ◽  
Vol 36 (6) ◽  
pp. 1132-1142 ◽  
Author(s):  
Sara Vaz-Pereira ◽  
Javier Zarranz-Ventura ◽  
Dawn A. Sim ◽  
Pearse A. Keane ◽  
Rebecca Smith ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Retinal Neovascularization ◽  
Optical Coherence
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