scholarly journals Isolated cotton-wool spots of unknown etiology: management and sequential spectral domain optical coherence tomography documentation

2011 ◽  
pp. 1431 ◽  
Author(s):  
Ioannides ◽  
Elaraoud ◽  
Georgakarakos ◽  
Andreou
Keyword(s):  
Optical Coherence Tomography ◽  
Spectral Domain ◽  
Unknown Etiology ◽  
Optical Coherence ◽  
Cotton Wool ◽  
Cotton Wool Spots

Features of cotton wool spots in diabetic retinopathy: a spectral-domain optical coherence tomography angiography study

2020 ◽  
Vol 40 (7) ◽  
pp. 1625-1640 ◽  
Author(s):  
Amir Mahdjoubi ◽  
Youcef Bousnina ◽  
Gaelle Barrande ◽  
Faïza Bensmaine ◽  
Sadri Chahed ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Optical Coherence Tomography Angiography ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Cotton Wool ◽  
Cotton Wool Spots

scholarly journals Cerebral malaria: insight into pathology from optical coherence tomography

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Zhanhan Tu ◽  
Jack Gormley ◽  
Viral Sheth ◽  
Karl B. Seydel ◽  
Terrie Taylor ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Neurological Deficits ◽  
Fundus Photography ◽  
Retinal Layer ◽  
Healthy Children ◽  
Optical Coherence ◽  
Cotton Wool ◽  
Post Discharge ◽  
Cotton Wool Spots ◽  
Diagnostic Potential

AbstractWe aimed to investigate structural retinal changes in malarial retinopathy (MR) using hand-held optical coherence tomography (HH-OCT) to assess its diagnostic potential. Children with MR (n = 43) underwent ophthalmoscopy, fluorescein angiography and HH-OCT during admission, 1-month (n = 31) and 1-year (n = 8) post-discharge. Controls were comatose patients without malaria (n = 6) and age/sex-matched healthy children (n = 43). OCT changes and retinal layer thicknesses were compared. On HH-OCT, hyper-reflective areas (HRAs) were seen in the inner retina of 81% of MR patients, corresponding to ischaemic retinal whitening on fundus photography. Cotton wool spots were present in 37% and abnormal hyper-reflective dots, co-localized to capillary plexus, in 93%. Hyper-reflective vessel walls were present in 84%, and intra-retinal cysts in 9%. Vascular changes and cysts resolved within 48 h. HRAs developed into retinal thinning at 1 month (p = 0.027) which was more pronounced after 1 year (p = 0.009). Ischaemic retinal whitening is located within inner retinal layers, distinguishing it from cotton wool spots. Vascular hyper-reflectivity may represent the sequestration of parasitized erythrocytes in vessels, a key CM feature. The mechanisms of post-ischemic retinal atrophy and cerebral atrophy with cognitive impairment may be similar in CM survivors. HH-OCT has the potential for monitoring patients, treatment response and predicting neurological deficits.

scholarly journals Cerebral Malaria: Insight into Pathology from Optical Coherence Tomography

2021 ◽  
Author(s):  
Zhanhan Tu ◽  
Jack Gormley ◽  
Viral Sheth ◽  
Karl B. Seydel ◽  
Terrie Taylor ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Neurological Deficits ◽  
Fundus Photography ◽  
Retinal Layer ◽  
Healthy Children ◽  
Optical Coherence ◽  
Cotton Wool ◽  
Cotton Wool Spots ◽  
Diagnostic Potential ◽  
One Year

Abstract PurposeWe aimed to investigate structural retinal changes in malarial retinopathy (MR) using hand-held optical coherence tomography (HH-OCT) to investigate its diagnostic potential.MethodsChildren with MR (n=43) underwent ophthalmoscopy, fluorescein angiography and HH-OCT during admission, one month (n=31) and one year (n=8) post-discharge. Controls were comatose patients without malaria (n=6) and age/sex-matched healthy children (n=43). OCT changes and retinal layer thicknesses were compared.ResultsOn HH-OCT, hyper-reflective areas (HRAs) were seen in the inner retina of 81% of MR patients, corresponding to ischaemic retinal whiteningon fundus photography. Cotton wool spots were present in 37% and abnormal hyper-reflective dots, co-localized to capillary plexus, in 93%. Hyper-reflective vessel walls were present in 84%, and intra-retinal cysts in 9%. Vascular changes and cysts resolved within 48 hours. HRAs developed into retinal thinning at one month (p=0.027) whichwas more pronounced after one year (p=0.009).ConclusionsIschaemic retinal whitening is located within inner retinal layers, distinguishing it from cotton wool spots. Vascular hyper-reflectivity may represent the sequestration of parasitized erythrocytes in vessels, a key CM feature. The mechanisms of post-ischemic retinal atrophy and cerebral atrophy with cognitive impairment may be similar in CM survivors. HH-OCT has potential for monitoring patients, treatment response and predicting neurological deficits.

Optical coherence tomography angiography characterization of acute and late stage Purtscher retinopathy

2018 ◽  
Vol 28 (4) ◽  
pp. NP1-NP6 ◽  
Author(s):  
Pedro Gil ◽  
Miguel Raimundo ◽  
João P Marques ◽  
João Póvoa ◽  
Rufino Silva
Keyword(s):  
Optical Coherence Tomography ◽  
Late Stage ◽  
Optical Coherence Tomography Angiography ◽  
Road Traffic ◽  
Optical Coherence ◽  
Cotton Wool ◽  
Fiber Layer ◽  
Cotton Wool Spots ◽  
Purtscher Retinopathy

Purpose: To report a case of Purtscher retinopathy imaged with optical coherence tomography angiography. Methods: Case-report. Left eye fundoscopic examination in a 21-year old male after a road traffic accident with chest compression revealed multiple peri-papillary cotton-wool spots and intra- and pre-retinal hemorrhages. A diagnosis of Purtscher retinopathy was assumed. Results: In both the superficial and deep retinal plexuses, acute stage optical coherence tomography angiography identified multiple irregular areas of capillary non-perfusion that extended beyond the clinically visible peri-papillary cotton-wool spots. At 5-month follow-up, despite the clearing of visible cotton-wool spots, there were still permanent areas of irregular capillary non-perfusion and inner retina atrophy. These sequelae, along with a decrease in the peri-papillary retinal nerve fiber layer thickness, were consistent with a suboptimal visual outcome and a dense inferior arcuate scotoma. Conclusion: Baseline and follow-up optical coherence tomography angiography was able to detect, quantify, and map focal microvascular abnormalities at the level of the superficial and deep inner retinal vascular plexuses. These lesions were consistent with late stage structural and functional sequelae, conferring them prognostic value.

In Vivo Histology of Cotton-Wool Spots Using High-Resolution Optical Coherence Tomography

2006 ◽  
Vol 141 (4) ◽  
pp. 748-750 ◽  
Author(s):  
Igor Kozak ◽  
Dirk-Uwe Bartsch ◽  
Lingyun Cheng ◽  
William R. Freeman
Keyword(s):  
Optical Coherence Tomography ◽  
High Resolution ◽  
Optical Coherence ◽  
Cotton Wool ◽  
Cotton Wool Spots

scholarly journals Cerebral Malaria: Insight into Pathology from Optical Coherence Tomography

2020 ◽  
Author(s):  
Zhanhan Tu ◽  
Jack Gormley ◽  
Viral Sheth ◽  
Karl Seydel ◽  
Terrie Taylor ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Neurological Deficits ◽  
Retinal Layer ◽  
Healthy Children ◽  
Optical Coherence ◽  
Cotton Wool ◽  
Post Discharge ◽  
Cotton Wool Spots ◽  
Diagnostic Potential ◽  
One Year

Abstract Purpose We aimed to investigate structural retinal changes in malarial retinopathy (MR) using hand-held optical coherence tomography (HH-OCT) to investigate its diagnostic potential.Methods Children with MR (n=43) underwent ophthalmoscopy, fluorescein angiography and HH-OCT during admission, one month (n=31) and one year (n=8) post-discharge. Controls were comatose patients without malaria (n=6) and age/sex-matched healthy children (n=43). OCT changes and retinal layer thicknesses were compared.Results On HH-OCT hyper-reflective areas (HRAs) were seen in the inner retina of 81% of MR patients, corresponding to ischaemic retinal whitening. Cotton wool spots present in 37% and abnormal hyper-reflective dots, co-localized to capillary plexi, in 93%. Hyper-reflective vessel walls were present in 84%, and intra-retinal cysts in 9%. Vascular changes and cysts resolved within 48 hours. HRAs developed into retinal thinning at one month (p=0.027) which was more pronounced after one year (p=0.009).Conclusions Ischaemic retinal whitening is located within inner retinal layers, distinguishing it from cotton wool spots. Vascular hyper-reflectivity may represent the sequestration of parasitized erythrocytes in vessels, a key CM feature. The mechanisms of post-ischemic retinal atrophy and cerebral atrophy with cognitive impairment may be similar in CM survivors. HH-OCT has potential for monitoring patients, treatment response and predicting neurological deficits.

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