Optical coherence tomography parameters predictive of visual outcome after anti-VEGF therapy for retinal vein occlusion

Background: To evaluate the longitudinal changes on optical coherence tomography angiography (OCTA) in retinal vein occlusion (RVO). Methods: Retrospective study of patients with RVO treated with intravitreal anti-vascular endothelial growth factors (VEGF) for macular edema. Foveal avascular zone (FAZ) area, vessel density (VD), vessel length density (VLD), and adjusted flow index (AFI) were calculated. The unaffected eye of each participant was used as a control. Results: Twelve RVO eyes were included, receiving 6 ± 3 anti-VEGF injections over a follow-up of 10.4 ± 3.1 months. Compared to fellow eyes, RVO eyes had lower VD and VLD at inclusion (p = 0.07 and p = 0.04) and last visit (p = 0.002 and p < 0.001). VD, AFI, and VLD did not change over time, while FAZ area increased in RVO eyes (+0.016 ± 0.024 mm2, p = 0.04). AFI correlated with duration of disease (r = 0.63, p = 0.02). Visual acuity was inversely related to VD and VLD over the follow-up. Conclusions: OCTA parameters remained stable with sustained anti-VEGF treatment in RVO, while changes in the FAZ area may suggest capillary remodeling after RVO.

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QUALITATIVE AND QUANTITATIVE FOLLOW-UP USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF RETINAL VEIN OCCLUSION TREATED WITH ANTI-VEGF

Retina ◽

10.1097/iae.0000000000001334 ◽

2017 ◽

Vol 37 (6) ◽

pp. 1176-1184 ◽

Cited By ~ 21

Author(s):

Alexandre Sellam ◽

Agnes Glacet-Bernard ◽

Florence Coscas ◽

Alexandra Miere ◽

Gabriel Coscas ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Retinal Vein Occlusion ◽

Optical Coherence Tomography Angiography ◽

Optical Coherence ◽

Qualitative And Quantitative ◽

Vein Occlusion ◽

Anti Vegf

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Visual prognostic value of photopic negative response and optical coherence tomography in central retinal vein occlusion after anti-VEGF treatment

Documenta Ophthalmologica ◽

10.1007/s10633-013-9379-9 ◽

2013 ◽

Vol 126 (3) ◽

pp. 211-219 ◽

Cited By ~ 3

Author(s):

Chan Hee Moon ◽

Sang Il Ahn ◽

Young-Hoon Ohn ◽

Hyung Woo Kwak ◽

Tae Kwann Park

Keyword(s):

Optical Coherence Tomography ◽

Retinal Vein Occlusion ◽

Central Retinal Vein Occlusion ◽

Prognostic Value ◽

Negative Response ◽

Photopic Negative Response ◽

Optical Coherence ◽

Vein Occlusion ◽

Anti Vegf ◽

Central Retinal Vein

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KARAKTERISTIK KETEBALAN MAKULA SENTRAL SEBELUM DAN SESUDAH INJEKSI INTRAVITREAL BEVACIZUMAB PADA PASIEN OKLUSI VENA RETINA DI RSKM PADANG EYE CENTER PERIODE JANUARI 2018 – JANUARI 2019

Health & Medical Journal ◽

10.33854/heme.v2i2.558 ◽

2020 ◽

Vol 2 (2) ◽

pp. 01-07

Author(s):

Haves Ashan

Keyword(s):

Optical Coherence Tomography ◽

Retinal Vein Occlusion ◽

Intravitreal Bevacizumab ◽

Optical Coherence ◽

Blood Retinal Barrier ◽

Vein Occlusion ◽

Anti Vegf

Edema makula merupakan penyebab umum terjadinya penurunan tajam penglihatan. Akumulasi cairan di dalam retina dan peningkatan ketebalan retina menyebabkan rusaknya blood retinal barrier. Injeksi intravitreal anti-VEGF (bevacizumab) bertujuan untuk mengurangi aktivitas VEGF, dimana oklusi vena pada retina (Retinal Vein Occlusion/ RVO) menginduksi peningkatan kadar VEGF yang menyebabkan peningkatan permeabilitas vaskular dan menimbulkan edema makula. Tujuan penelitian ini adalah Mengetahui ketebalan makula sentral sebelum dan sesudah injeksi intravitreal bevacizumab pada pasien oklusi vena retina sentral dan oklusi vena retina cabang melalui pengamatan hasil pemeriksaan OCT (Optical Coherence Tomography). Penelitian ini merupakan penelitian deskriptif retrospektif berdasarkan hasil penelusuran rekam medis terhadap 8 pasien RVO di RSKM Padang Eye Center periode Januari 2018 sampai Januari 2019. Penelitian dilakukan pada bulan Maret hingga April 2020. Subyek penelitian sebanyak 8 orang (8 mata) terdiri dari 2 laki-laki (25,0%) dan 6 perempuan (75,0%). Rentang usia berkisar antara 41-80 tahun. Ketebalan makula sentral saat awal didapatkan mayoritas > 300 µm yaitu sebanyak 7 orang (87,5%), sedangkan ≤ 300 µm sebanyak 1 orang (12,5%). Satu bulan pasca injeksi didapatkan mayoritas ketebalan makula sentral ≤ 300 µm sebanyak 5 orang (62,5%), sedangkan > 300 µm yaitu sebanyak 3 orang (37,5%). semua pasien mengalami penurunan ketebalan makula sentral yaitu sebanyak 8 subjek (100%).

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