scholarly journals Articular cartilage repair and the evolving role of regenerative medicine

2010 ◽  
pp. 109 ◽  
Author(s):  
Pieter Koen Bos
2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Caining Wen ◽  
Limei Xu ◽  
Xiao Xu ◽  
Daping Wang ◽  
Yujie Liang ◽  
...  

AbstractArticular cartilage repair is a critical issue in osteoarthritis (OA) treatment. The insulin-like growth factor (IGF) signaling pathway has been implicated in articular cartilage repair. IGF-1 is a member of a family of growth factors that are structurally closely related to pro-insulin and can promote chondrocyte proliferation, enhance matrix production, and inhibit chondrocyte apoptosis. Here, we reviewed the role of IGF-1 in cartilage anabolism and catabolism. Moreover, we discussed the potential role of IGF-1 in OA treatment. Of note, we summarized the recent progress on IGF delivery systems. Optimization of IGF delivery systems will facilitate treatment application in cartilage repair and improve OA treatment efficacy.


2002 ◽  
Vol 26 (3) ◽  
pp. 131-136 ◽  
Author(s):  
Pecina M. ◽  
Jelic M. ◽  
Martinovic S. ◽  
Haspl M. ◽  
Vukicevic S.

2001 ◽  
Vol 9 ◽  
pp. S48-S54 ◽  
Author(s):  
J. Weisser ◽  
B. Rahfoth ◽  
A. Timmermann ◽  
T. Aigner ◽  
R. Bräuer ◽  
...  

2007 ◽  
pp. 283-309 ◽  
Author(s):  
Monika Volesky ◽  
Timothy Charlton ◽  
Jonathan T. Deland

2002 ◽  
pp. 249-262 ◽  
Author(s):  
Mislav Jelic ◽  
Marko Pecina ◽  
Miroslav Haspl ◽  
Anton Brkic ◽  
Slobodan Vukicevic

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