scholarly journals Alveolar Hemorrhage Following Thrombolytic Therapy for Acute Myocardial Infarction: Two Case Reports and Literature Review

2021 ◽  
Vol Volume 13 ◽  
pp. 399-405
Author(s):  
Imtinene Ben Mrad ◽  
Melek Ben Mrad ◽  
Zeineb Oumaya ◽  
Ihsen Zairi ◽  
Bouthaina Besbes ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Literature Review ◽  
Thrombolytic Therapy ◽  
Case Reports ◽  
Alveolar Hemorrhage

Diffuse Alveolar Hemorrhage following Thrombolytic Therapy for Acute Myocardial Infarction

Respiration ◽  
2000 ◽  
Vol 67 (4) ◽  
pp. 445-448 ◽  
Author(s):  
Mordechai Yigla ◽  
Eli Sprecher ◽  
Zaher Azzam ◽  
Luda Guralnik ◽  
Michael Kapeliovich ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Thrombolytic Therapy ◽  
Diffuse Alveolar Hemorrhage ◽  
Alveolar Hemorrhage

The safety of automatic versus manual blood pressure cuffs for patients receiving thrombolytic therapy

1998 ◽  
Vol 7 (3) ◽  
pp. 192-196 ◽  
Author(s):  
L Saul ◽  
J Smith ◽  
W Mook
Keyword(s):  
Myocardial Infarction ◽  
Blood Pressure ◽  
Acute Myocardial Infarction ◽  
Thrombolytic Therapy ◽  
Case Reports ◽  
Significant Difference ◽  
Increase Risk ◽  
Automatic Blood Pressure ◽  
Research Findings ◽  
Manual Blood Pressure

BACKGROUND: Patients receiving thrombolytic therapy for acute myocardial infarction require frequent monitoring of blood pressure. Historically, many nurses have been reluctant to use automatic blood pressure cuffs during thrombolytic therapy because of concern that the automatic cuffs might increase risk of bleeding. This concern is not based on research findings but on case reports, anecdotal observations, and possible myths in clinical practice. OBJECTIVE: To determine the safety of using automatic blood pressure cuffs during thrombolytic therapy in patients with acute myocardial infarction. METHODS: Ninety-six patients with acute myocardial infarction who received thrombolytic therapy (streptokinase or tissue plasminogen activator) were randomized to have blood pressure measurements obtained with either automatic or manual blood pressure cuffs. Patients were checked at least every 2 hours for purpuric lesions (petechiae, ecchymoses, or hematomas). The study ended after 24 hours of measurements or when a purpuric lesion was noted. RESULTS: We found no significant difference in frequency of purpuric lesions between patients who had blood pressure measured with a manual cuff and patients who had blood pressure measured with an automatic cuff. The most common purpuric lesions noted were ecchymoses. A significant difference was noted in the frequency of purpuric lesions depending on which thrombolytic agent was used, regardless of cuff type. CONCLUSIONS: Automatic blood pressure cuffs are as safe as manual blood pressure cuffs in patients with acute myocardial infarction who are receiving thrombolytic therapy.

scholarly journals TERAPIA TROMBOLÍTICA NO IAM: UMA REVISÃO DA LITERATURA

2017 ◽  
Vol 7 (20) ◽  
pp. 22
Author(s):  
Carlos Alves dos Santos
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Literature Review ◽  
Thrombolytic Therapy ◽  
Nursing Care ◽  
Atheromatous Plaque ◽  
The Universe ◽  
Infarto Del Miocardio ◽  
De Medicina

O infarto agudo do miocárdio (IAM) é causado pela obstrução de uma ou de ambas as artérias coronárias por uma placa de ateroma. Quando isso ocorre em algumas circunstâncias é necessário instituir a terapia trombolítica, que consiste na administração de um fármaco que dissolve essa placa. O objetivo deste estudo foi investigar o papel do enfermeiro na terapia trombolítica diante do IAM. Tratou-se de um trabalho de revisão da literatura. Para isso, utilizou-se como fonte de pesquisa o site de busca da BIREME (Biblioteca Regional de Medicina). Do universo de 15 artigos, observou-se que 6 artigos mencionavam de forma indireta o papel do enfermeiro na terapia trombolítica e apenas 1 artigo citava os cuidados de enfermagem. Notou-se que o papel do enfermeiro vai além dos cuidados de enfermagem descritos nos livros de enfermagem.Descritores: Infarto do Miocárdio, Fibrinólise, Cuidados de Enfermagem. Thrombolytic therapy in AMI: an review of the literatureAbstract: Acute myocardial infarction (AMI) is caused by obstruction of one or both of the coronary arteries by an atheromatous plaque. When this occurs in some circumstances, it is necessary to institute thrombolytic therapy, which consists of the administration of a drug that dissolves this plaque. The objective of this study was to investigate the role of nurses in thrombolytic therapy in the presence of AMI. It was a work of literature review. To do this, the BIREME (Regional Library of Medicine) website was used as research source. From the universe of 15 articles, it was observed that 6 articles mentioned in an indirect way the role of the nurse in thrombolytic therapy and only 1 article cited nursing care. It was noted that the role of the nurse goes beyond the nursing care described in the in the nursing books.Descriptors: Myocardial Infarction, Fibrinolysis, Nursing Care. Terapia trombolítica en el IAM: una revisión de la literaturaResumen: Infarto agudo del miocardio (IAM) es causada por la obstrucción de una o ambas arterias coronarias por ateroma. Cuando esto ocurre por algunas circunstancias es una necesidad la terapia trombolítica, que comprende la administración de un fármaco que disuelve esta placa. El objetivo de este estudio fue investigar el papel de la enfermera en la terapia trombolítica antes del IAM. Se realizó un trabajo de revisión de la literatura. Para esto, se utilizo como una fuente de la investigación del site de busca de la BIREME (Biblioteca Regional de Medicina). Escogido el universo de 15 artículos, se observó que 6 artículos, menciona indirectamente el papel de las enfermeras en la terapia trombolítica siendo que sólo 1 artículo citaba los cuidados de enfermería. Se observó que el papel de la enfermera va más allá de la atención de enfermería que se describe en los libros de enfermería.Descriptores: Infarto del Miocardio, Fibrinólisis, Cuidados de Enfermería.

Relationship of Plasminogen Activator Inhibitor-1 Levels following Thrombolytic Therapy with rt-PA as Compared to Streptokinase and Patency of Infarct Related Coronary Artery

1999 ◽  
Vol 82 (07) ◽  
pp. 104-108 ◽  
Author(s):  
Franck Paganelli ◽  
Marie Christine Alessi ◽  
Pierre Morange ◽  
Jean Michel Maixent ◽  
Samuel Lévy ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Thrombolytic Therapy ◽  
Plasminogen Activator ◽  
Plasminogen Activator Inhibitor ◽  
Control Group ◽  
Plasminogen Activator Inhibitor 1 ◽  
Vessel Patency ◽  
Activator Inhibitor ◽  
Pai 1

Summary Background: Type 1 plasminogen activator inhibitor (PAI-1) is considered to be risk factor for acute myocardial infarction (AMI). A rebound of circulating PAI-1 has been reported after rt-PA administration. We investigated the relationships between PAI-1 levels before and after thrombolytic therapy with streptokinase (SK) as compared to rt-PA and the patency of infarct-related arteries. Methods and Results: Fifty five consecutive patients with acute MI were randomized to strep-tokinase or rt-PA. The plasma PAI-1 levels were studied before and serially within 24 h after thrombolytic administration. Vessel patency was assessed by an angiogram at 5 ± 1days. The PAI-1 levels increased significantly with both rt-PA and SK as shown by the levels obtained from a control group of 10 patients treated with coronary angioplasty alone. However, the area under the PAI-1 curve was significantly higher with SK than with rt-PA (p <0.01) and the plasma PAI-1 levels peaked later with SK than with rt-PA (18 h versus 3 h respectively). Conversely to PAI-1 levels on admission, the PAI-1 levels after thrombolysis were related to vessel patency. Plasma PAI-1 levels 6 and 18 h after SK therapy and the area under the PAI-1 curve were significantly higher in patients with occluded arteries (p <0.002, p <0.04 and p <0.05 respectively).The same tendency was observed in the t-PA group without reaching significance. Conclusions: This study showed that the PAI-1 level increase is more pronounced after SK treatment than after t-PA treatment. There is a relationship between increased PAI-1 levels after thrombolytic therapy and poor patency. Therapeutic approaches aimed at quenching PAI-1 activity after thrombolysis might be of interest to improve the efficacy of thrombolytic therapy for acute myocardial infarction.

Thrombolytic Therapy in the Current ERA: Myocardial Infarction and Beyond

2018 ◽  
Vol 24 (4) ◽  
pp. 414-426 ◽  
Author(s):  
Patrick Proctor ◽  
Massoud A. Leesar ◽  
Arka Chatterjee
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Acute Myocardial Infarction ◽  
Percutaneous Coronary Intervention ◽  
Ischemic Stroke ◽  
Thrombolytic Therapy ◽  
Coronary Intervention ◽  
Evidence Base ◽  
Primary Pci ◽  
Percutaneous Coronary

Thrombolytic therapy kick-started the era of modern cardiology but in the last few decades it has been largely supplanted by primary percutaneous coronary intervention (PCI) as the go-to treatment for acute myocardial infarction. However, these agents remain important for vast populations without access to primary PCI and acute ischemic stroke. More innovative uses have recently come up for the treatment of a variety of conditions. This article summarizes the history, evidence base and current use of thrombolytics in cardiovascular disease.

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