scholarly journals Predicting cell adhesion receptors using protein sequence index

2011 ◽  
pp. 97 ◽  
Author(s):  
Zhijun Wang ◽  
Xu Chunyan ◽  
Yu Feng ◽  
Lin Tang ◽  
Jianhua He ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Protein Sequence ◽  
Adhesion Receptors

scholarly journals The Small GTPase Rap1b: A Bidirectional Regulator of Platelet Adhesion Receptors

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Gianni Francesco Guidetti ◽  
Mauro Torti
Keyword(s):  
Cell Adhesion ◽  
Signaling Pathways ◽  
Platelet Adhesion ◽  
Thrombus Formation ◽  
Small Gtpases ◽  
Small Gtpase ◽  
Complex Pattern ◽  
Adhesive Properties ◽  
Adhesion Receptors ◽  
Inside Out

Integrins and other families of cell adhesion receptors are responsible for platelet adhesion and aggregation, which are essential steps for physiological haemostasis, as well as for the development of thrombosis. The modulation of platelet adhesive properties is the result of a complex pattern of inside-out and outside-in signaling pathways, in which the members of the Rap family of small GTPases are bidirectionally involved. This paper focuses on the regulation of the main Rap GTPase expressed in circulating platelets, Rap1b, downstream of adhesion receptors, and summarizes the most recent achievements in the investigation of the function of this protein as regulator of platelet adhesion and thrombus formation.

Differential expression of R- and N-cadherin in neural and mesodermal tissues during early chicken development

Development ◽  
1991 ◽  
Vol 113 (3) ◽  
pp. 959-967 ◽  
Author(s):  
H. Inuzuka ◽  
C. Redies ◽  
M. Takeichi
Keyword(s):  
Cell Adhesion ◽  
Differential Expression ◽  
Neural Tube ◽  
Immunoblot Analysis ◽  
Spatial Segregation ◽  
Differentially Expressed ◽  
Adhesion Receptors ◽  
Chicken Embryos ◽  
Neural Tissues ◽  
Chicken Development

R-cadherin is a newly identified member of the cadherin family of cell adhesion receptors. The expression of R-cadherin in early chicken embryos was studied using affinity-purified antibodies to this molecule, comparing it with that of N-cadherin. Immunoblot analysis of various organs of 10.5-day embryos showed that R-cadherin is most abundantly expressed in the retina and brain. Immunostaining of the cervical and thoracic regions of embryos revealed that R- and N-cadherin are expressed in all neural tissues. In the neural tube, R-cadherin appears at around stage 21, although N-cadherin expression begins at a much earlier stage. The distribution of R-cadherin in the neural tube differs from that of N-cadherin; for example, some regions of the tube express only R-cadherin, and other regions only N-cadherin. In the peripheral ganglia, these two cadherins are also expressed in different patterns which change during development. Some mesenchymal tissues including the notochord, the myotome, myotubes and perichondria also express these cadherins, again in different patterns. Thus, R- and N-cadherin are differentially expressed in all the tissues examined, and they may contribute to the spatial segregation of heterogeneous cells in a tissue.

Expression of cell adhesion receptors in human osteoblasts cultured on biofunctionalized poly-(ε-caprolactone) surfaces

Biomaterials ◽  
2007 ◽  
Vol 28 (25) ◽  
pp. 3668-3678 ◽  
Author(s):  
Ilaria Amato ◽  
Gabriela Ciapetti ◽  
Stefania Pagani ◽  
Giovanni Marletta ◽  
Cristina Satriano ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Receptors ◽  
Human Osteoblasts

scholarly journals Cell adhesion receptors in C. elegans

2004 ◽  
Vol 117 (10) ◽  
pp. 1867-1870 ◽  
Author(s):  
E. A. Cox
Keyword(s):  
Cell Adhesion ◽  
Adhesion Receptors ◽  
C Elegans

Detection and spatial distribution of the beta 2 integrin (Mac-1) and L-selectin (LECAM-1) adherence receptors on human neutrophils by high-resolution field emission SEM.

1993 ◽  
Vol 41 (3) ◽  
pp. 327-333 ◽  
Author(s):  
S L Erlandsen ◽  
S R Hasslen ◽  
R D Nelson
Keyword(s):  
Cell Adhesion ◽  
High Resolution ◽  
Field Emission ◽  
Cell Body ◽  
Human Neutrophils ◽  
Adhesion Receptors ◽  
Backscatter Electron Imaging ◽  
Beta 2 ◽  
Electron Imaging ◽  
Small Clusters

We have developed a method utilizing high-resolution field emission SEM and backscatter electron imaging of immunogold for detection of cell adhesion receptors on the surface of unfixed human neutrophils, using indirect immunogold localization of specific murine monoclonal antibodies (MAb) to the cell adhesion receptors L-selectin (LECAM-1) and the beta 2 integrin (Mac-1). We have observed that these two receptor populations occupy different membrane domains on the surface of unactivated human neutrophils. LECAM-1 was observed to occur in clusters on the tips of microvilli or membrane ruffles and was seldom detected on the membrane of the cell body. On the other hand, Mac-1 was found mainly on the membrane of the cell body in unactivated neutrophils, either singly or in small clusters, and was only rarely encountered on microvilli or ruffles. In contrast, the distribution of Mac-1 on activated, spreading neutrophils was markedly increased (up-regulated) and occurred in clusters on both the membrane of the cell body and also of surface projections, i.e., microvilli and ruffles. The unique distributions of LECAM-1 and Mac-1 on the surface of unactivated human neutrophils, as observed by high-resolution LVSEM, confirm the spatial relationships of these receptor types as predicted by models for the attachment of circulating neutrophils to vascular endothelium and their emigration to sites of inflammation.

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