scholarly journals Long-term morphine addiction reduces neurogenesis and memory performance and alters emotional reactivity and anxiety levels in male rats

2015 ◽  
pp. 129 ◽  
Author(s):  
Morteza Karimian ◽  
Hamidreza Famitafreshi ◽  
Narges Marefati
Keyword(s):  
Emotional Reactivity ◽  
Memory Performance ◽  
Male Rats ◽  
Morphine Addiction ◽  
Anxiety Levels

scholarly journals Integrating Study Designs on Emotional Reactivity and Regulation in Old Age: New Evidence From the EMIL Study

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 330-331
Author(s):  
Oliver Schilling ◽  
Gloria Luong
Keyword(s):  
Longitudinal Study ◽  
Old Age ◽  
Cognitive Aging ◽  
Emotional Reactivity ◽  
Daily Life ◽  
Memory Performance ◽  
Empathic Accuracy ◽  
Study Designs

Abstract Key insights into emotional reactivity and regulation have been gained by studying how these dynamics evolve as older people are confronted with controlled stressors in the lab, go about their everyday routines, or develop across adulthood and old age. Yet, we are only beginning to understand how the dynamics on the different time scales observed in these study designs interact . Aiming for a comprehensive picture of the predictors, correlates, and consequences of emotional reactivity and regulation, the EMIL study integrates a lab-based study with ambulatory in-vivo assessments and a classic long-term longitudinal study. 130 young-old (65-69 years) and 59 very-old adults (83-89 years) from the ILSE study, contributing four waves of health, cognitive, and psycho-social data over almost 25 years, were tested in the lab and assessed six times a day over seven consecutive days. We provide an overview of and first across-design results from EMIL: Katzorreck et al. examined whether the frequency of exposure to daily stressors affects emotion regulation capacity as tested in the lab. Lücke et al. analyzed daily working memory performance, sleep, and its association with long-term change in cognitive functioning. Wieck et al. present differential effects of discrete negative emotions as induced in the lab and reported in daily life on social cognitive performance as indicated by empathic accuracy. Gerstorf et al. examined how long-term cognitive aging affects positive feelings and stressor reactivity in daily life. Gloria Luong will discuss the presentations, considering challenges and opportunities of integrating lab-based, ambulatory, and longitudinal study designs.

Assessment of long-term effects of smoke from wildfires on white rats

2020 ◽  
Vol 60 (11) ◽  
pp. 720-722
Author(s):  
Elizaveta S. Andreeva
Keyword(s):  
Cognitive Abilities ◽  
Memory Performance ◽  
Recovery Period ◽  
White Male ◽  
Reproductive Function ◽  
Male Rats ◽  
Long Term Effects ◽  
Wildfire Smoke ◽  
White Rats

Introduction. The study of the effects of wildfire smoke on the reproductive function is the most important scientific problem at the present stage. The aim of study is to study the behavior and cognitive abilities of sexually mature offspring obtained from white male rats exposed to the smoke of wildfires. Materials and methods. Experiments were carried out on 30 white male rats and 60 adult male of their offspring. The duration of exposure was 4 weeks, 4 hours/day. To obtain progeny exposed males were mated with intact females immediately after the exposure and in long-term period after exposure. Examination of adult progeny was performed using the "open field", Morris water maze, and histological examination of brain tissue. Results. Behavioral and cognitive alterations in offspring of male rats exposed to wildfire smoke were obtained: significant decrease in motor activity and research on higher level of negative emotional state, impaired spatial memory performance. Individuals from offspring obtained in a long-term period after exposure to smoke showed a normalization of the studied parameters to background values. Conclusions. The long-term consequences of exposure to the smoke of wildfires were revealed, manifested in the offspring of the first generation in the form of impaired behavior and cognitive abilities. The recovery period after prolonged smoke intoxication, which is 60 days and is comparable in duration with the duration of spermatogenesis in rats, is important for reducing the risk of developing CNS disorders in offspring.

Short- and long-term memory tasks predict working memory performance, and vice versa.

2019 ◽  
Vol 73 (2) ◽  
pp. 79-93 ◽  
Author(s):  
Ian Neath ◽  
Jean Saint-Aubin ◽  
Tamra J. Bireta ◽  
Andrew J. Gabel ◽  
Chelsea G. Hudson ◽  
...  
Keyword(s):  
Working Memory ◽  
Memory Performance ◽  
Long Term Memory ◽  
Term Memory ◽  
Short And Long Term

scholarly journals Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy

2021 ◽  
Vol 54 (1) ◽  
Author(s):  
Mayarling Francisca Troncoso ◽  
Mario Pavez ◽  
Carlos Wilson ◽  
Daniel Lagos ◽  
Javier Duran ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Cardiac Hypertrophy ◽  
Glucose Uptake ◽  
Male Rats ◽  
Cardiomyocyte Hypertrophy ◽  
Mrna Levels ◽  
Elevated Glucose ◽  
Amp Activated Protein Kinase ◽  
Cultured Cardiomyocytes

Abstract Background Testosterone regulates nutrient and energy balance to maintain protein synthesis and metabolism in cardiomyocytes, but supraphysiological concentrations induce cardiac hypertrophy. Previously, we determined that testosterone increased glucose uptake—via AMP-activated protein kinase (AMPK)—after acute treatment in cardiomyocytes. However, whether elevated glucose uptake is involved in long-term changes of glucose metabolism or is required during cardiomyocyte growth remained unknown. In this study, we hypothesized that glucose uptake and glycolysis increase in testosterone-treated cardiomyocytes through AMPK and androgen receptor (AR). Methods Cultured cardiomyocytes were stimulated with 100 nM testosterone for 24 h, and hypertrophy was verified by increased cell size and mRNA levels of β-myosin heavy chain (β-mhc). Glucose uptake was assessed by 2-NBDG. Glycolysis and glycolytic capacity were determined by measuring extracellular acidification rate (ECAR). Results Testosterone induced cardiomyocyte hypertrophy that was accompanied by increased glucose uptake, glycolysis enhancement and upregulated mRNA expression of hexokinase 2. In addition, testosterone increased AMPK phosphorylation (Thr172), while inhibition of both AMPK and AR blocked glycolysis and cardiomyocyte hypertrophy induced by testosterone. Moreover, testosterone supplementation in adult male rats by 5 weeks induced cardiac hypertrophy and upregulated β-mhc, Hk2 and Pfk2 mRNA levels. Conclusion These results indicate that testosterone stimulates glucose metabolism by activation of AMPK and AR signaling which are critical to induce cardiomyocyte hypertrophy.

The timing of maternal separation affects morris water maze performance and long-term potentiation in male rats

2013 ◽  
Vol 56 (5) ◽  
pp. 1102-1109 ◽  
Author(s):  
Xiujing Cao ◽  
Shenghai Huang ◽  
Jiejie Cao ◽  
Tingting Chen ◽  
Ping Zhu ◽  
...  
Keyword(s):  
Morris Water Maze ◽  
Water Maze ◽  
Maternal Separation ◽  
Long Term Potentiation ◽  
Male Rats ◽  
Maze Performance ◽  
Term Potentiation
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