scholarly journals Social isolation is associated with reduced neurogenesis, impaired spatial working memory performance, and altered anxiety levels in male rats

2015 ◽  
pp. 87 ◽  
Author(s):  
Morteza Karimian ◽  
Hamidreza Famitafreshi ◽  
Hamed Fanaei ◽  
Fatemeh Attari ◽  
Sulail Fatima
Keyword(s):  
Working Memory ◽  
Social Isolation ◽  
Spatial Working Memory ◽  
Memory Performance ◽  
Male Rats ◽  
Anxiety Levels

Effect of Centella asiatica Ethanol Extract in Spatial Working Memory on Adult Male Rats

2018 ◽  
Vol 24 (8) ◽  
pp. 6109-6111 ◽  
Author(s):  
Auliyani Andam Suri ◽  
Astri Handayani ◽  
Adibah Ferhad ◽  
Siti Farida ◽  
Sri Redjeki
Keyword(s):  
Working Memory ◽  
Adult Male ◽  
Wistar Rats ◽  
Spatial Working Memory ◽  
Memory Performance ◽  
Centella Asiatica ◽  
Ethanol Extract ◽  
Male Rats ◽  
Normal Adult ◽  
Male Adult

Cognitive decline can be started at early adult. It may be prevented with administration of Centella asiatica (CeA). CeA already known has some medicinal values for the brain such as to increase dendritic growth, to improve cognitive function and memory performance in rats after chronic stress. Objective: This study is aimed to investigate effect CeA ethanol extract on spatial working memory of normal adult male rats. Eighteen normal adult male Wistar rats were divided into three groups: control/aquadest group and two groups treated with different doses (mg/kg) of CeA: 300 (CeA300) and 600 (CeA600). Ethanol extract of CeA were administrated orally for 28 consecutive days with weekly weight-adjusted dose. Memory performance was tested using Y-Maze before, on 14th days of treatment and after treatment. Data were analyzed using Kruskal-Wallis test and continued with Mann-Whitney test. Result: Treatment groups showed a better spatial working memory performance than control group, but there were no significant result between CeA300 and CeA600 groups (p < 0.05). Ethanol extract of CeA prevents spatial working memory decline on normal male adult Wistar rats. The optimum dosage of CeA might be 300 mg/kg of body weight.

scholarly journals Resting‐State EEG Microstates Parallel Age‐Related Differences in Allocentric Spatial Working Memory Performance

2021 ◽  
Author(s):  
Adeline Jabès ◽  
Giuliana Klencklen ◽  
Paolo Ruggeri ◽  
Christoph M. Michel ◽  
Pamela Banta Lavenex ◽  
...  
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Resting State ◽  
Cognitive Aging ◽  
Temporal Dynamics ◽  
Spatial Working Memory ◽  
Brain Activity ◽  
Memory Performance ◽  
Brain Regions ◽  
Age Related

AbstractAlterations of resting-state EEG microstates have been associated with various neurological disorders and behavioral states. Interestingly, age-related differences in EEG microstate organization have also been reported, and it has been suggested that resting-state EEG activity may predict cognitive capacities in healthy individuals across the lifespan. In this exploratory study, we performed a microstate analysis of resting-state brain activity and tested allocentric spatial working memory performance in healthy adult individuals: twenty 25–30-year-olds and twenty-five 64–75-year-olds. We found a lower spatial working memory performance in older adults, as well as age-related differences in the five EEG microstate maps A, B, C, C′ and D, but especially in microstate maps C and C′. These two maps have been linked to neuronal activity in the frontal and parietal brain regions which are associated with working memory and attention, cognitive functions that have been shown to be sensitive to aging. Older adults exhibited lower global explained variance and occurrence of maps C and C′. Moreover, although there was a higher probability to transition from any map towards maps C, C′ and D in young and older adults, this probability was lower in older adults. Finally, although age-related differences in resting-state EEG microstates paralleled differences in allocentric spatial working memory performance, we found no evidence that any individual or combination of resting-state EEG microstate parameter(s) could reliably predict individual spatial working memory performance. Whether the temporal dynamics of EEG microstates may be used to assess healthy cognitive aging from resting-state brain activity requires further investigation.

scholarly journals Age-Related Differences in Resting-State EEG and Allocentric Spatial Working Memory Performance

2021 ◽  
Vol 13 ◽  
Author(s):  
Adeline Jabès ◽  
Giuliana Klencklen ◽  
Paolo Ruggeri ◽  
Jean-Philippe Antonietti ◽  
Pamela Banta Lavenex ◽  
...  
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Resting State ◽  
Spatial Working Memory ◽  
Brain Activity ◽  
Memory Performance ◽  
Group Differences ◽  
Age Group ◽  
Eeg Activity ◽  
Recording Conditions

During normal aging resting-state brain activity changes and working memory performance declines as compared to young adulthood. Interestingly, previous studies reported that different electroencephalographic (EEG) measures of resting-state brain activity may correlate with working memory performance at different ages. Here, we recorded resting-state EEG activity and tested allocentric spatial working memory in healthy young (20–30 years) and older (65–75 years) adults. We adapted standard EEG methods to record brain activity in mobile participants in a non-shielded environment, in both eyes closed and eyes open conditions. Our study revealed some age-group differences in resting-state brain activity that were consistent with previous results obtained in different recording conditions. We confirmed that age-group differences in resting-state EEG activity depend on the recording conditions and the specific parameters considered. Nevertheless, lower theta-band and alpha-band frequencies and absolute powers, and higher beta-band and gamma-band relative powers were overall observed in healthy older adults, as compared to healthy young adults. In addition, using principal component and regression analyses, we found that the first extracted EEG component, which represented mainly theta, alpha and beta powers, correlated with spatial working memory performance in older adults, but not in young adults. These findings are consistent with the theory that the neurobiological bases of working memory performance may differ between young and older adults. However, individual measures of resting-state EEG activity could not be used as reliable biomarkers to predict individual allocentric spatial working memory performance in young or older adults.

scholarly journals Negative Effects of Embodiment in a Visuo-Spatial Working Memory Task in Children, Young Adults, and Older Adults

2021 ◽  
Vol 12 ◽  
Author(s):  
Gianluca Amico ◽  
Sabine Schaefer
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Young Adults ◽  
Spatial Information ◽  
Spatial Working Memory ◽  
Cognitive Task ◽  
Memory Performance ◽  
Age Groups ◽  
Memory Task ◽  
Negative Effects

Studies examining the effect of embodied cognition have shown that linking one’s body movements to a cognitive task can enhance performance. The current study investigated whether concurrent walking while encoding or recalling spatial information improves working memory performance, and whether 10-year-old children, young adults, or older adults (Mage = 72 years) are affected differently by embodiment. The goal of the Spatial Memory Task was to encode and recall sequences of increasing length by reproducing positions of target fields in the correct order. The nine targets were positioned in a random configuration on a large square carpet (2.5 m × 2.5 m). During encoding and recall, participants either did not move, or they walked into the target fields. In a within-subjects design, all possible combinations of encoding and recall conditions were tested in counterbalanced order. Contrary to our predictions, moving particularly impaired encoding, but also recall. These negative effects were present in all age groups, but older adults’ memory was hampered even more strongly by walking during encoding and recall. Our results indicate that embodiment may not help people to memorize spatial information, but can create a dual-task situation instead.

scholarly journals Tyrosine depletion alters cortical and limbic blood flow but does not modulate spatial working memory performance or task-related blood flow in humans

2007 ◽  
Vol 28 (11) ◽  
pp. 1136-1149 ◽  
Author(s):  
Kathryn A. Ellis ◽  
Mitul A. Mehta ◽  
P.J. Naga Venkatesha Murthy ◽  
Sarah F.B. McTavish ◽  
Pradeep J. Nathan ◽  
...  
Keyword(s):  
Working Memory ◽  
Blood Flow ◽  
Spatial Working Memory ◽  
Memory Performance ◽  
Tyrosine Depletion ◽  
Or Task

Combined D1/D2 receptor stimulation under conditions of dopamine depletion impairs spatial working memory performance in humans

2005 ◽  
Vol 181 (4) ◽  
pp. 771-780 ◽  
Author(s):  
Kathryn A. Ellis ◽  
Mitul A. Mehta ◽  
Keith A. Wesnes ◽  
Stuart Armstrong ◽  
Pradeep J. Nathan
Keyword(s):  
Working Memory ◽  
Spatial Working Memory ◽  
Memory Performance ◽  
D2 Receptor ◽  
Dopamine Depletion ◽  
Receptor Stimulation

Testosterone modulates performance on a spatial working memory task in male rats

2006 ◽  
Vol 50 (1) ◽  
pp. 18-26 ◽  
Author(s):  
Noah J. Sandstrom ◽  
Ju H. Kim ◽  
Molly A. Wasserman
Keyword(s):  
Working Memory ◽  
Spatial Working Memory ◽  
Memory Task ◽  
Male Rats

The α2 agonist, clonidine, improves spatial working memory performance in Parkinson's disease

Neuroscience ◽  
1999 ◽  
Vol 92 (3) ◽  
pp. 983-989 ◽  
Author(s):  
M. Riekkinen ◽  
P. Jäkälä ◽  
K. Kejonen ◽  
P. Riekkinen
Keyword(s):  
Parkinson’S Disease ◽  
Working Memory ◽  
Parkinson's Disease ◽  
Spatial Working Memory ◽  
Memory Performance
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