scholarly journals Spectral Power Analysis of Sleep Electroencephalography in Subjects with Different Severities of Obstructive Sleep Apnea and Healthy Controls

2021 ◽  
Vol Volume 13 ◽  
pp. 477-486
Author(s):  
Jae Myeong Kang ◽  
Seo-Eun Cho ◽  
Kyoung-Sae Na ◽  
Seung-Gul Kang
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Power Analysis ◽  
Spectral Power ◽  
Healthy Controls ◽  
Obstructive Sleep ◽  
Spectral Power Analysis

scholarly journals 0054 Metabolite Profiles of Obstructive Sleep Apnea Distinguishes Cases from Controls and Improve With CPAP

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A21-A22
Author(s):  
A Sengupta ◽  
D C Lim ◽  
B T Keenan ◽  
L Keele ◽  
A Pack ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Methionine Sulfoxide ◽  
Ultra Performance Liquid Chromatography ◽  
Healthy Controls ◽  
Serum Samples ◽  
Metabolomics Data ◽  
Cpap Treatment ◽  
Clinical Biomarkers ◽  
Obstructive Sleep

Abstract Introduction Obstructive sleep apnea (OSA) is a common sleep breathing disorder with significant public health consequences. Despite this, no clinically available objective molecular biomarkers to diagnose, risk stratify and quantify treatment efficiency exist. To this end, high-throughput metabolomics data could serve as a valuable quantitative tool. Methods We designed a pilot study to investigate the metabolomic effects of OSA and CPAP treatment. Blood serum samples were collected from OSA patients and healthy controls matched with respect to age (±5 years), BMI (±2.5 kg/m2) and gender (N = 20/group). Samples from OSA patients were obtained before and after continuous positive airway pressure (CPAP) treatment. Polar metabolites were analyzed using a targeted ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) metabolomics technique. Results Supervised multivariate analysis using serum metabolic values of OSA patients and healthy controls showed a significantly different overall metabolic profile between the two groups (orthogonal partial least squares discriminant analysis [OPLS-DA] Q2=0.25, p=0.04). Acetylornithine, choline, cytidine, dodecenoylcarnitine, methionine sulfoxide and 3-indoxylsulfate were among the most perturbed metabolites. Major metabolic pathways altered in the OSA patients were methionine and phospholipid metabolism, as well as gut microbial co-metabolism. Lysophosphatidylcholine (16:0), a phospholipid metabolite, demonstrated significant linear association with improved oxygen saturation nadir post CPAP treatment (R2 = 0.57), suggesting the metabolic features may be used as prognostic clinical biomarkers. Conclusion These results suggest that OSA significantly impacts blood metabolites, which could potentially be used to establish OSA biomarkers. Moreover, specific metabolic features are associated with post CPAP improvement, such as phospholipids, suggesting a functional association of these metabolites that may help us understand the heterogeneity of OSA. Overall, these results demonstrate the potential of metabolic profiling to develop quantitative molecular markers of OSA. Further studies are underway to validate these findings and investigate the utility of metabolic profiles to objectively measure CPAP efficacy. Support The work was supported by the program project grant P01 HL094307.

scholarly journals 0044 The Circadian System Modulates Cardiovascular Responses To Standing Differently In People With Obstructive Sleep Apnea Compared To Healthy Controls.

SLEEP ◽  
2019 ◽  
Vol 42 (Supplement_1) ◽  
pp. A18-A18
Author(s):  
Saurabh S Thosar ◽  
Matthew P Butler ◽  
Nicole P Bowles ◽  
Andrew W McHill ◽  
Alec M Berman ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Cardiovascular Responses ◽  
Circadian System ◽  
Healthy Controls ◽  
Obstructive Sleep

T1963 Pharyngeal Reflux of Gastric Content: Mechanisms in Healthy Controls, Gastroesophageal Reflux and Obstructive Sleep Apnea Patients

2008 ◽  
Vol 134 (4) ◽  
pp. A-588-A-589
Author(s):  
Shiko Kuribayashi ◽  
Lilani P. Perera ◽  
Muhammad Hafeezullah ◽  
Ahmed Nasef ◽  
Linda Tatro ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Gastroesophageal Reflux ◽  
Gastric Content ◽  
Healthy Controls ◽  
Obstructive Sleep ◽  
Pharyngeal Reflux

scholarly journals Sleep Spindle Characteristics in Obstructive Sleep Apnea Syndrome (OSAS)

2021 ◽  
Vol 12 ◽  
Author(s):  
Hiwa Mohammadi ◽  
Ardalan Aarabi ◽  
Mohammad Rezaei ◽  
Habibolah Khazaie ◽  
Serge Brand
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Healthy Controls ◽  
Sleep Spindle ◽  
Rapid Eye Movement Sleep ◽  
Obstructive Sleep ◽  
Apnea Syndrome ◽  
Post Hoc

Background: We compared the density and duration of sleep spindles topographically in stage 2 and 3 of non-rapid eye movement sleep (N2 and N3) among adults diagnosed with Obstructive Sleep Apnea Syndrome (OSAS) and healthy controls.Materials and Methods: Thirty-one individuals with OSAS (mean age: 48.50 years) and 23 healthy controls took part in the study. All participants underwent a whole night polysomnography. Additionally, those with OSAS were divided into mild, moderate and severe cases of OSAS.Results: For N2, sleep spindle density did not significantly differ between participants with and without OSAS, or among those with mild, moderate and severe OSAS. For N3, post-hoc analyses revealed significantly higher spindle densities in healthy controls and individuals with mild OSAS than in those with moderate or severe OSAS. Last, in N2 a higher AHI was associated with a shorter sleep spindle duration.Conclusion: OSAS is associated with a significantly lower spindle density in N3 and a shorter spindle duration in N2. Our results also revealed that, in contrast to moderate and severe OSAS, the sleep spindle characteristics of individuals with mild OSAS were very similar to those of healthy controls.

scholarly journals Task Positive and Default Mode Networks during a Parametric Working Memory Task in Obstructive Sleep Apnea Patients and Healthy Controls

SLEEP ◽  
2011 ◽  
Vol 34 (3) ◽  
pp. 293-301 ◽  
Author(s):  
Olga Prilipko ◽  
Nelly Huynh ◽  
Sophie Schwartz ◽  
Visasiri Tantrakul ◽  
Jee Hyun Kim ◽  
...  
Keyword(s):  
Working Memory ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Memory Task ◽  
Healthy Controls ◽  
Default Mode ◽  
Obstructive Sleep

scholarly journals Association between Serum Homocysteine Level and Obstructive Sleep Apnea: A Meta-Analysis

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Kun Li ◽  
Jing Zhang ◽  
Yanwen Qin ◽  
Yong-Xiang Wei
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Quality Assessment ◽  
Meta Analysis ◽  
Control Group ◽  
Healthy Controls ◽  
China National Knowledge Infrastructure ◽  
Association Analyses ◽  
Serum Homocysteine ◽  
Obstructive Sleep

Background. Obstructive sleep apnea (OSA) is a common problem that affects human health. Researches have reported a variety of results with reference to the association between OSA and serum homocysteine (Hcy) level. This meta-analysis is proposed to figure out the association between serum Hcy level and OSA.Methods. Eligible studies were identified via searching PubMed, Embase, and China National Knowledge Infrastructure (CNKI). Two independent reviewers reviewed studies. The Newcastle-Ottawa Quality Assessment Scale (NOS) was employed for quality assessment of included studies. RevMan (5.1) software and STATA (12.0) software were applied to data analyses.Results. 10 studies containing 839 subjects were included in the present meta-analysis; results revealed that Hcy levels in OSA group were 2.40 μmol/l higher than that in control group (95% confidence interval: 0.6 to 4.20,P<0.01;I2=96%). Subgroup analysis showed a significant increase of serum Hcy level in OSA patients compared with healthy controls when apnea hyperpnoea index (AHI) >= 30.Conclusions. Serum Hcy levels and OSA have close-knit and significant association. Analyses demonstrated that patients with OSA had a higher serum Hcy level than healthy controls. In addition, this difference is more significant in moderate or severe OSA patients.

scholarly journals Relation between IL-8 level and obstructive sleep apnea syndrome

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 683-691
Author(s):  
Qing-Cui Zeng ◽  
Qin Sun ◽  
Min Zhang ◽  
Yi Tang ◽  
Huai-Cong Long
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Serum Level ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Sleep Apnea Syndrome ◽  
Healthy Controls ◽  
Obstructive Sleep ◽  
Apnea Syndrome ◽  
The Relationship

Abstract Objective This meta-analysis was conducted to explore the relationship between serum level of IL-8 and obstructive sleep apnea syndrome (OSAS). Methods Electronic databases were retrieved according to the inclusion and exclusion criteria, relevant studies exploring the relationship between serum level of IL-8 and OSAS were enrolled. Statistical analysis was performed using STATA 12.0. Results Totally 199 studies were retrieved, among which 10 were qualified for the inclusion criteria and were finally included in the meta-analysis with 367 cases of OSAS patients and 335 control cases. Serum level of IL-8 was higher in patients than healthy controls (Standard mean difference (SMD) = 2.16, 95% CI = 1.17–3.15, P < 0.001). The subgroup analysis based on ethnicity revealed that average serum level of IL-8 were higher in Asian and Caucasian OSAS patients than healthy controls (Asian: SMD = 2.50, 95% CI = 1.13–3.87, P < 0.001; Caucasian: SMD = 1.59, 95% CI = 0.11–3.06, P = 0.035). Further subgroup analysis based on age indicated a statistical difference in serum level of IL-8 between adult OSAS patients and healthy counterparts (SMD = 2.73, 95% CI = 1.49–3.98, P < 0.001). Conclusion The level of IL-8 was related to OSAS in adult patients, and increased serum IL-8 level may increase the risk of OSAS.

scholarly journals Upper airway dynamic imaging during tidal breathing in awake and asleep subjects with obstructive sleep apnea and healthy controls

2018 ◽  
Vol 6 (10) ◽  
pp. e13711 ◽  
Author(s):  
Chantal Darquenne ◽  
Ann R. Elliott ◽  
Bastien Sibille ◽  
Erik T. Smales ◽  
Pamela N. DeYoung ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Upper Airway ◽  
Dynamic Imaging ◽  
Healthy Controls ◽  
Tidal Breathing ◽  
Obstructive Sleep
Sign in / Sign up

Export Citation Format

Share Document