scholarly journals Association between Serum Homocysteine Level and Obstructive Sleep Apnea: A Meta-Analysis

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Kun Li ◽  
Jing Zhang ◽  
Yanwen Qin ◽  
Yong-Xiang Wei
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Quality Assessment ◽  
Meta Analysis ◽  
Control Group ◽  
Healthy Controls ◽  
China National Knowledge Infrastructure ◽  
Association Analyses ◽  
Serum Homocysteine ◽  
Obstructive Sleep

Background. Obstructive sleep apnea (OSA) is a common problem that affects human health. Researches have reported a variety of results with reference to the association between OSA and serum homocysteine (Hcy) level. This meta-analysis is proposed to figure out the association between serum Hcy level and OSA.Methods. Eligible studies were identified via searching PubMed, Embase, and China National Knowledge Infrastructure (CNKI). Two independent reviewers reviewed studies. The Newcastle-Ottawa Quality Assessment Scale (NOS) was employed for quality assessment of included studies. RevMan (5.1) software and STATA (12.0) software were applied to data analyses.Results. 10 studies containing 839 subjects were included in the present meta-analysis; results revealed that Hcy levels in OSA group were 2.40 μmol/l higher than that in control group (95% confidence interval: 0.6 to 4.20,P<0.01;I2=96%). Subgroup analysis showed a significant increase of serum Hcy level in OSA patients compared with healthy controls when apnea hyperpnoea index (AHI) >= 30.Conclusions. Serum Hcy levels and OSA have close-knit and significant association. Analyses demonstrated that patients with OSA had a higher serum Hcy level than healthy controls. In addition, this difference is more significant in moderate or severe OSA patients.

scholarly journals Relation between IL-8 level and obstructive sleep apnea syndrome

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 683-691
Author(s):  
Qing-Cui Zeng ◽  
Qin Sun ◽  
Min Zhang ◽  
Yi Tang ◽  
Huai-Cong Long
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Serum Level ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Sleep Apnea Syndrome ◽  
Healthy Controls ◽  
Obstructive Sleep ◽  
Apnea Syndrome ◽  
The Relationship

Abstract Objective This meta-analysis was conducted to explore the relationship between serum level of IL-8 and obstructive sleep apnea syndrome (OSAS). Methods Electronic databases were retrieved according to the inclusion and exclusion criteria, relevant studies exploring the relationship between serum level of IL-8 and OSAS were enrolled. Statistical analysis was performed using STATA 12.0. Results Totally 199 studies were retrieved, among which 10 were qualified for the inclusion criteria and were finally included in the meta-analysis with 367 cases of OSAS patients and 335 control cases. Serum level of IL-8 was higher in patients than healthy controls (Standard mean difference (SMD) = 2.16, 95% CI = 1.17–3.15, P < 0.001). The subgroup analysis based on ethnicity revealed that average serum level of IL-8 were higher in Asian and Caucasian OSAS patients than healthy controls (Asian: SMD = 2.50, 95% CI = 1.13–3.87, P < 0.001; Caucasian: SMD = 1.59, 95% CI = 0.11–3.06, P = 0.035). Further subgroup analysis based on age indicated a statistical difference in serum level of IL-8 between adult OSAS patients and healthy counterparts (SMD = 2.73, 95% CI = 1.49–3.98, P < 0.001). Conclusion The level of IL-8 was related to OSAS in adult patients, and increased serum IL-8 level may increase the risk of OSAS.

scholarly journals Associations Between Morning Salivary and Blood Cortisol Concentrations in Individuals With Obstructive Sleep Apnea Syndrome: A Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Mohammad Moslem Imani ◽  
Masoud Sadeghi ◽  
Habibolah Khazaie ◽  
Arezoo Sanjabi ◽  
Serge Brand ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Plasma Cortisol ◽  
Meta Analysis ◽  
Sleep Apnea Syndrome ◽  
Healthy Controls ◽  
Obstructive Sleep ◽  
Morning Cortisol ◽  
Apnea Syndrome

BackgroundObstructive sleep apnea syndrome (OSAS) may be associated with an increase in hypothalamic-pituitary-adrenocortical axis activity (HPA AA). We reviewed research comparing morning salivary and blood (serum and plasma) cortisol concentrations of individuals with OSAS to those of healthy controls.MethodsWe made a systematic search without any restrictions of the PubMed/Medline, Scopus, Cochrane Library, and Web of Science databases for relevant articles published up to August 25, 2019.ResultsSixteen studies were analyzed in this meta-analysis; five studies compared morning salivary concentrations, five compared serum concentrations, four compared plasma cortisol concentrations, and two compared both salivary and plasma concentrations. In pediatric samples, compared to healthy controls, those with OSAS had significantly lower saliva morning cortisol concentrations (MD = -0.13 µg/dl; 95% CI: 0.21, -0.04; P = 0.003). In contrast, no significant differences were observed for serum cortisol concentrations, plasma cortisol concentrations, or salivary morning cortisol concentrations between adults with and without OSAS (p = 0.61, p = 0.17, p = 0.17).ConclusionCortisol concentrations did not differ between adults with OSAS and healthy controls. In contrast, morning salivary cortisol concentrations were lower in children with OSAS, compared to healthy controls. Given that a reduced HPA AA is observed among individuals with chronic stress, it is conceivable that children with OSAS are experiencing chronic psychophysiological stress.

scholarly journals Effect of Cooling Irrigating Saline in Tongue Base Ablation in Obstructive Sleep Apnea

OTO Open ◽  
2021 ◽  
Vol 5 (1) ◽  
pp. 2473974X2198959
Author(s):  
Ahmed Yassin Bahgat
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Controlled Trial ◽  
Tongue Base ◽  
Control Group ◽  
University Hospitals ◽  
Energy Field ◽  
Obstructive Sleep ◽  
Prospective Randomized Controlled Trial ◽  
Significant Difference

Objective Plasma is formed by creating a high-density energy field within an electrically conductive fluid such as saline. Sometimes ablated bits of tissue get stuck between the electrodes of the wand, obstructing the suction channel. The purpose of this study is to investigate the effect of cooling the irrigating saline during ablation of the hypertrophied tongue base in patients with obstructive sleep apnea. Study Design Prospective randomized controlled trial. Setting An otorhinolaryngology department in Main University hospitals. Methods Sixty adult patients with obstructive sleep apnea and tongue base hypertrophy underwent tongue base ablation surgery. Patients were randomly divided into 2 groups of 30 patients each: cooled saline and room temperature saline. The Coblation wand used was the EVac 70 Xtra HP (Smith & Nephew). Results In this study, a significant difference in operative time (mean ± SD) was seen between groups: 21.2 ± 5.5 minutes in the cold group and 47 ± 9.5 minutes in the control group ( P = .001). The wands in the cold group did not obstruct, while all the wands in the control group were obstructed by tissue clogs with variable degrees, hence wasting more time to clean the wands’ tips. Conclusion Cooling the irrigating saline overcame the problem of wand clogs, and the wand tip did not occlude at all during the procedures, thus saving time lost in wand cleaning and demonstrating a faster and safer surgical procedure. Further studies are needed to identify the hemostatic effect of the cooled saline over the regular one.

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