scholarly journals Bacterial Biofilm Destruction: A Focused Review On The Recent Use of Phage-Based Strategies With Other Antibiofilm Agents

2021 ◽  
Vol Volume 14 ◽  
pp. 161-177
Author(s):  
Stephen Amankwah ◽  
Kedir Abdusemed ◽  
Tesfaye Kassa
Keyword(s):  
Bacterial Biofilm ◽  
Biofilm Destruction ◽  
Antibiofilm Agents

scholarly journals In VitroActivities of Dermaseptins K4S4and K4K20S4against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa Planktonic Growth and Biofilm Formation

2014 ◽  
Vol 58 (4) ◽  
pp. 2221-2228 ◽  
Author(s):  
Amira Zaïri ◽  
Lionel Ferrières ◽  
Patricia Latour-Lambert ◽  
Christophe Beloin ◽  
Frédéric Tangy ◽  
...  
Keyword(s):  
Biofilm Formation ◽  
Alternative Therapies ◽  
Bacterial Biofilm ◽  
Flow Conditions ◽  
Dynamic Flow ◽  
Gram Negative ◽  
Cytotoxicity Assays ◽  
Attached Bacteria ◽  
Antibiofilm Agents ◽  
Intensive Search

ABSTRACTThe rising number of infections caused by biofilm formation and the difficulties associated with their treatment by conventional antimicrobial therapies have led to an intensive search for novel antibiofilm agents. Dermaseptins are antimicrobial peptides with a number of attractive properties that might offer alternative therapies against resistant microorganisms. In this study, we synthesized a set of dermaseptin-derived peptides and evaluated their activities against Gram-positive and Gram-negative bacterial biofilm formation. All dermaseptin-derived peptides demonstrated concentration-dependent antibiofilm activities at microgram concentrations, and their activities were dependent on the nature of the peptides, with the highest levels of activity being exhibited by highly charged molecules. Fluorescent binding and confocal microscopy demonstrated that dermaseptin K4S4, a substituted derivative of the native molecule S4, significantly decreased the viability of planktonic and surface-attached bacteria and stopped biofilm formation under dynamic flow conditions. Cytotoxicity assays with HeLa cells showed that some of the tested peptides were less cytotoxic than current antibiotics. Overall, these findings indicate that dermaseptin derivatives might constitute new lead structures for the development of potent antibiofilm agents.

Bacterial biofilm destruction by size/surface charge-adaptive micelles

Nanoscale ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 1410-1422 ◽  
Author(s):  
Maohua Chen ◽  
Jiaojun Wei ◽  
Songzhi Xie ◽  
Xinyan Tao ◽  
Zhanlin Zhang ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Surface Charge ◽  
Pathogenic Bacteria ◽  
Bacterial Biofilm ◽  
Biofilm Destruction

Biofilms formed by pathogenic bacteria are one of the most important reasons for multidrug resistance.

Insights into Peptide Mediated Antibiofilm Treatment in Chronic Wound; A Bench to Bedside Approach

2020 ◽  
Vol 21 ◽  
Author(s):  
Megha Periyappilly Radhakrishnan ◽  
Karthika Suryaletha ◽  
Aparna Shankar ◽  
Akhila Velappan Savithri ◽  
Sanil George ◽  
...  
Keyword(s):  
Synthetic Peptide ◽  
Antimicrobial Agents ◽  
Chronic Wounds ◽  
Chronic Wound ◽  
Alternative Therapy ◽  
Multidrug Resistant ◽  
Bacterial Biofilm ◽  
Morbidity And Mortality ◽  
Antibiofilm Activity ◽  
Antibiofilm Agents

: Chronic wound biofilm infections are a threat to the population with respect to morbidity and mortality. Presence of multidrug resistant bacterial pathogens in chronic wound renders the action of antibiotics and antibiofilm agents difficult. Therefore an alternative therapy is essential for reducing bacterial biofilm burden. In this scenario, the peptide based antibiofilm therapy for chronic wound biofilm management seeks more attention. Synthetic peptide with a broad range of antibiofilm activity against preformed and established biofilms, ability to kill multispecies bacteria within biofilms and combinatorial activity with other antimicrobial agents give significant insights. In this review we portray the possibilities and difficulties of peptide mediated treatment in chronic wounds biofilm management and how it can be clinically translated into a product.

Bacterial biofilm behavior in water-supply lines of dental units

1992 ◽  
Vol 50 (1) ◽  
pp. 882-883
Author(s):  
B.D. Tall ◽  
K.S. George ◽  
R. T. Gray ◽  
H.N. Williams
Keyword(s):  
Water Supply ◽  
Medical Devices ◽  
Biofilm Formation ◽  
Bacterial Biofilm

Studies of bacterial behavior in many environments have shown that most organisms attach to surfaces, forming communities of microcolonies called biofilms. In contaminated medical devices, biofilms may serve both as reservoirs and as inocula for the initiation of infections. Recently, there has been much concern about the potential of dental units to transmit infections. Because the mechanisms of biofilm formation are ill-defined, we investigated the behavior and formation of a biofilm associated with tubing leading to the water syringe of a dental unit over a period of 1 month.

The In Vitro Antibiofilm Activity of Water Leaf Extract of Papaya (Carica papaya L.) against Pseudomonas aeruginosa

2017 ◽  
Vol 2 (3) ◽  
pp. 150-163
Author(s):  
Ekajayanti Kining ◽  
Syamsul Falah ◽  
Novik Nurhidayat
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Contact Time ◽  
Cell Attachment ◽  
Water Extract ◽  
Opportunistic Pathogen ◽  
Bacterial Biofilm ◽  
Antibiofilm Activity ◽  
Bacterial Survival ◽  
Optimum Conditions

Pseudomonas aeruginosa is one of opportunistic pathogen forming bacterial biofilm. The biofilm sustains the bacterial survival and infections. This study aimed to assess the activity of water extract of papaya leaves on inhibition of cells attachment, growth and degradation of the biofilm using crystal violet (CV) biofilm assay. Research results showed that water extract of papaya leaves contains alkaloids, tanins, flavonoids, and steroids/terpenoids and showed antibacterial activity and antibiofilm against P. aeruginosa. Addition of extract can inhibit the cell attachment and was able to degrade the biofilm of 40.92% and 48.058% respectively at optimum conditions: extract concentration of 25% (v/v), temperature 37.5 °C and contact time 45 minutes. With a concentration of 25% (v/v), temperature of 50 °C and the contact time of 3 days, extract of papaya leaves can inhibit the growth of biofilms of 39.837% v/v.

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