scholarly journals No change in N-acetyl aspartate in first episode of moderate depression after antidepressant treatment: 1H magnetic spectroscopy study of left amygdala and left dorsolateral prefrontal cortex

2014 ◽  
pp. 1753 ◽  
Author(s):  
Maja Bajs Janovic ◽  
Petra Kalember ◽  
Neven Henigsberg ◽  
Spiro Janovic ◽  
Pero Hrabac ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Antidepressant Treatment ◽  
First Episode ◽  
Spectroscopy Study ◽  
Moderate Depression ◽  
Dorsolateral Prefrontal

Proton spectroscopy study of the left dorsolateral prefrontal cortex in pediatric depressed patients

2005 ◽  
Vol 384 (3) ◽  
pp. 321-326 ◽  
Author(s):  
Sheila C. Caetano ◽  
Manoela Fonseca ◽  
Rene L. Olvera ◽  
Mark Nicoletti ◽  
John P. Hatch ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Spectroscopy Study ◽  
Proton Spectroscopy ◽  
Depressed Patients ◽  
Dorsolateral Prefrontal

scholarly journals Changes in distributed neural circuitry function in patients with first-episode schizophrenia

2004 ◽  
Vol 185 (3) ◽  
pp. 205-214 ◽  
Author(s):  
A. Mendrek ◽  
K. R. Laurens ◽  
K. A. Kiehl ◽  
E. T. C. Ngan ◽  
E. Stip ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Memory Task ◽  
First Episode ◽  
Related Phenomenon ◽  
Cingulate Gyrus ◽  
Dorsolateral Prefrontal ◽  
Stable Characteristic ◽  
The Right ◽  
First Episode Schizophrenia

BackgroundA number of functional brain abnormalities have been reported in schizophrenia, but it remains to be determined which of them represent trait and state markers of the illness.AimsTo delineate regional brain dysfunctions that remain stable and those that fluctuate during the course of schizophrenia.MethodA cohort of patients with first-episode schizophrenia and a matched group of control participants underwent functional magnetic resonance imaging on two occasions 6–8 weeks apart during performance of a working memory task. The patients' disease was in partial remission at the second scan.ResultsRelative to control participants, the function of the left dorsolateral prefrontal cortex, left thalamus and right cerebellum remained disturbed in the people with schizophrenia, whereas the dysfunction of the right dorsolateral prefrontal cortex, right thalamus, left cerebellum and cingulate gyrus normalised, with significant reduction in symptoms.ConclusionsThese results suggest that dysfunction of the left fronto-thalamo-cerebellar circuitry is a relatively stable characteristic of schizophrenia, whereas disturbance of the right circuitry and cingulate gyrus is predominantly a state-related phenomenon.

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