scholarly journals Inhibition of miR-448-3p Attenuates Cerebral Ischemic Injury by Upregulating Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2)

2021 ◽  
Vol Volume 17 ◽  
pp. 3147-3158
Author(s):  
Min Xu ◽  
Dingchao Xiang ◽  
Wenhua Wang ◽  
Long Chen ◽  
Wei Lu ◽  
...  
Keyword(s):  
Ischemic Injury ◽  
Related Factor ◽  
Nuclear Factor ◽  
Cerebral Ischemic Injury ◽  
Cerebral Ischemic

scholarly journals Resveratrol Preconditioning Protects Against Cerebral Ischemic Injury via Nuclear Erythroid 2–Related Factor 2

Stroke ◽  
2015 ◽  
Vol 46 (6) ◽  
pp. 1626-1632 ◽  
Author(s):  
Srinivasan V. Narayanan ◽  
Kunjan R. Dave ◽  
Isa Saul ◽  
Miguel A. Perez-Pinzon
Keyword(s):  
Ischemic Injury ◽  
Related Factor ◽  
Cerebral Ischemic Injury ◽  
Cerebral Ischemic

scholarly journals Simvastatin Reduces Lipopolysaccharides-Accelerated Cerebral Ischemic Injury via Inhibition of Nuclear Factor-kappa B Activity

2015 ◽  
Vol 23 (6) ◽  
pp. 531-538 ◽  
Author(s):  
Angela M. A. Anthony Jalin ◽  
Jae-Chul Lee ◽  
Geum-Sil Cho ◽  
Chunsook Kim ◽  
Chung Ju ◽  
...  
Keyword(s):  
Nuclear Factor Kappa B ◽  
Ischemic Injury ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Cerebral Ischemic Injury ◽  
Cerebral Ischemic

scholarly journals Intradialytic Cerebral Hypoperfusion as Mechanism for Cognitive Impairment in Patients on Hemodialysis

2019 ◽  
Vol 30 (11) ◽  
pp. 2052-2058 ◽  
Author(s):  
Dawn F. Wolfgram
Keyword(s):  
Cognitive Impairment ◽  
Cerebral Perfusion ◽  
Ischemic Injury ◽  
Hemodialysis Patients ◽  
Cognitive Outcomes ◽  
Cerebral Injury ◽  
Cerebral Hypoperfusion ◽  
Increased Risk ◽  
Cerebral Ischemic Injury ◽  
Cerebral Ischemic

The high frequency of cognitive impairment in individuals on hemodialysis is well characterized. In-center hemodialysis patients are disproportionately affected by cognitive impairment compared with other dialysis populations, identifying hemodialysis itself as a possible factor. The pathophysiology of cognitive impairment has multiple components, but vascular-mediated cerebral injury appears to contribute based on studies demonstrating increased cerebral ischemic lesions and atrophy in brain imaging of patients on hemodialysis. Patients on hemodialysis may be at increased risk for cerebral ischemic injury disease due to vasculopathy associated with ESKD and from their comorbid diseases, such as hypertension and diabetes. This review focuses on the intradialytic cerebral hypoperfusion that can occur during routine hemodialysis due to the circulatory stress of hemodialysis. This includes a review of current methods used to monitor intradialytic cerebral perfusion and the structural and functional cognitive outcomes that have been associated with changes in intradialytic cerebral perfusion. Monitoring of intradialytic cerebral perfusion may become clinically relevant as nephrologists try to avoid the cognitive complications seen with hemodialysis. Identifying the appropriate methods to assess risk for cerebral ischemic injury and the relationship of intradialytic cerebral hypoperfusion to cognitive outcomes will help inform the decision to use intradialytic cerebral perfusion monitoring in the clinical setting as part of a strategy to prevent cognitive decline.

Sign in / Sign up

Export Citation Format

Share Document