scholarly journals Using a novel in vivo model to study the function of nuclear factor kappa B in cerebral ischemic injury

2012 ◽  
Vol 18 (11) ◽  
pp. BR461-BR467 ◽  
Author(s):  
Rui Wang ◽  
Songlan Liang ◽  
Hui Yue ◽  
LIjie Chen
Keyword(s):  
Nuclear Factor Kappa B ◽  
Ischemic Injury ◽  
In Vivo Model ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Cerebral Ischemic Injury ◽  
Cerebral Ischemic

scholarly journals Simvastatin Reduces Lipopolysaccharides-Accelerated Cerebral Ischemic Injury via Inhibition of Nuclear Factor-kappa B Activity

2015 ◽  
Vol 23 (6) ◽  
pp. 531-538 ◽  
Author(s):  
Angela M. A. Anthony Jalin ◽  
Jae-Chul Lee ◽  
Geum-Sil Cho ◽  
Chunsook Kim ◽  
Chung Ju ◽  
...  
Keyword(s):  
Nuclear Factor Kappa B ◽  
Ischemic Injury ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Cerebral Ischemic Injury ◽  
Cerebral Ischemic

L-Tetrahydropalmatine Inhibits the Progression of Glioblastoma Tumor by Suppressing the Extracellular-Signal-Regulated Kinase/Nuclear Factor-Kappa B Signaling Pathway

2020 ◽  
Vol 19 (2) ◽  
pp. 164-171
Author(s):  
Feng Xue ◽  
Tingting Chen
Keyword(s):  
Glioblastoma Multiforme ◽  
Nuclear Factor Kappa B ◽  
Matrix Metalloproteinase 2 ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Extracellular Signal ◽  
Apoptosis Protein ◽  
Endothelial Growth Factor

Glioblastoma multiforme is the most common malignancy of central nervous system. Herein we have evaluated the effect of L-tetrahydropalmatine, an isoquinoline alkaloid, on the tumor growth both in vivo and in vitro using C6 glioblastoma multiforme cells and BALB/c mice injected subcutaneously with C6/luc2 cells. The results of these studies show that L-tetrahydropalmatine exhibited cytotoxic effect on C6 glioblastoma multiforme cells, suppressed nuclear factor-kappa B activity, suppressed the levels of tumor-linked proteins such as matrix metalloproteinase-2/9, Cyclin-D1, vascular endothelial growth factor, and X-linked inhibitor of apoptosis protein via ERK/nuclear factor-kappa B cascade. Further, L-tetrahydropalmatine inhibited the cell migration and invasion properties of C6 cells, and also suppressed the tumor weight and volume in mice. Immunohistochemical staining of tumor tissues suggested that L-tetrahydropalmatine inhibited the extracellular-signal-regulated kinase/nuclear factor-kappa B cascade and suppressed the levels of Cyclin-D1; matrix metalloproteinase-2/9; X-linked inhibitor of apoptosis protein; and vascular endothelial growth factor, and also the progression and growth of glioblastoma multiforme in mice. In summary, L-tetrahydropalmatine inhibits the ERK/nuclear factor-kappa B cascade, decreases the tumor volume, and inhibits the proteins responsible for tumor growth both in vivo and in vitro.

scholarly journals Inhibition of nuclear factor kappa-B signaling reduces growth in medulloblastoma in vivo

BMC Cancer ◽  
2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Susan E Spiller ◽  
Naomi J Logsdon ◽  
Lindsey A Deckard ◽  
Harald Sontheimer
Keyword(s):  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa
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