scholarly journals Asymmetry of Subthalamic Neuronal Firing Rate and Oscillatory Characteristics in Parkinson’s Disease [Retraction]

2020 ◽  
Vol Volume 16 ◽  
pp. 975-976
Author(s):  
Xue-Min Zhao ◽  
Ping Zhuang ◽  
Yong-jie Li ◽  
Yu-qing Zhang ◽  
Jian-yu Li ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Firing Rate ◽  
Neuronal Firing ◽  
Neuronal Firing Rate

scholarly journals Subthalamic nucleus neuronal firing rate increases with Parkinson's disease progression

2011 ◽  
Vol 26 (9) ◽  
pp. 1657-1662 ◽  
Author(s):  
Michael S. Remple ◽  
Courtney H. Bradenham ◽  
C. Chris Kao ◽  
P. David Charles ◽  
Joseph S. Neimat ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Firing Rate ◽  
Disease Progression ◽  
Subthalamic Nucleus ◽  
Neuronal Firing ◽  
Neuronal Firing Rate

Changes in neuronal firing rate in the subthalamic nucleus with Parkinson's disease

2012 ◽  
Vol 27 (3) ◽  
pp. 455-456 ◽  
Author(s):  
Michael S. Remple ◽  
Courtney H. Bradenham ◽  
C. Chris Kao ◽  
P. David Charles ◽  
Joseph S. Neimat ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Firing Rate ◽  
Subthalamic Nucleus ◽  
Neuronal Firing ◽  
Neuronal Firing Rate

scholarly journals Asymmetry of Subthalamic Neuronal Firing Rate and Oscillatory Characteristics in Parkinson’s Disease

2020 ◽  
Vol Volume 16 ◽  
pp. 313-323
Author(s):  
Xue-Min Zhao ◽  
Ping Zhuang ◽  
Yong-jie Li ◽  
Yu-qing Zhang ◽  
Jian-yu Li ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Firing Rate ◽  
Neuronal Firing ◽  
Neuronal Firing Rate

Subthalamic Nucleus Neuronal Firing Rate Increases with Parkinson's Disease Progression

Neurosurgery ◽  
2009 ◽  
Vol 65 (2) ◽  
pp. 422-422
Author(s):  
Michael S. Remple ◽  
Courtney H. Hayes ◽  
Chang Qing Kao ◽  
P. David Charles ◽  
Joseph Samir Neimat ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Firing Rate ◽  
Disease Progression ◽  
Subthalamic Nucleus ◽  
Neuronal Firing ◽  
Neuronal Firing Rate

Internal Pallidal Neuronal Activity During Mild Drug-Related Dyskinesias in Parkinson's Disease: Decreased Firing Rates and Altered Firing Patterns

2007 ◽  
Vol 97 (4) ◽  
pp. 2627-2641 ◽  
Author(s):  
J. I. Lee ◽  
L. Verhagen Metman ◽  
S. Ohara ◽  
P. M. Dougherty ◽  
J. H. Kim ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Firing Rate ◽  
Spike Trains ◽  
Neuronal Firing ◽  
Low Doses ◽  
Significant Group ◽  
Firing Patterns ◽  
Firing Rates ◽  
Before And After

The neuronal basis of hyperkinetic movement disorders has long been unclear. We now test the hypothesis that changes in the firing pattern of neurons in the globus pallidus internus (GPi) are related to dyskinesias induced by low doses of apomorphine in patients with advanced Parkinson's disease (PD). During pallidotomy for advanced PD, the activity of single neurons was studied both before and after administration of apomorphine at doses just adequate to induce dyskinesias (21 neurons, 17 patients). After the apomorphine injection, these spike trains demonstrated an initial fall in firing from baseline. In nine neurons, the onset of on was simultaneous with that of dyskinesias. In these spike trains, the initial fall in firing rate preceded and was larger than the fall at the onset of on with dyskinesias. Among the three neurons in which the onset of on occurred before that of dyskinesias, the firing rate did not change at the time of onset of dyskinesias. After injection of apomorphine, dyskinesias during on with dyskinesias often fluctuated between transient periods with dyskinesias and those without. Average firing rates were not different between these two types of transient periods. Transient periods with dyskinesias were characterized by interspike interval (ISI) independence, stationary spike trains, and higher variability of ISIs. A small but significant group of neurons demonstrated recurring ISI patterns during transient periods of on with dyskinesias. These results suggest that mild dyskinesias resulting from low doses of apomorphine are related to both low GPi neuronal firing rates and altered firing patterns.

scholarly journals Neuronal Firing Rates and Patterns in the Globus Pallidus Internus of Patients With Cervical Dystonia Differ From Those With Parkinson's Disease

2007 ◽  
Vol 98 (2) ◽  
pp. 720-729 ◽  
Author(s):  
Joyce K. H. Tang ◽  
Elena Moro ◽  
Neil Mahant ◽  
William D. Hutchison ◽  
Anthony E. Lang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Firing Rate ◽  
Globus Pallidus ◽  
Cervical Dystonia ◽  
Neuronal Firing ◽  
Globus Pallidus Internus ◽  
Motor Symptoms ◽  
Firing Rates ◽  
Irregular Pattern

Cervical dystonia (CD) is a movement disorder that involves involuntary turning and twisting of the neck caused by abnormal muscle contraction. Deep brain stimulation (DBS) in the globus pallidus internus (GPi) is used to treat both CD and the motor symptoms of Parkinson's disease (PD). It has been suggested that the differing motor symptoms in CD and PD may arise from a decreased GPi output in CD and elevation of output in PD. To test this hypothesis, extracellular recordings of GPi neuronal activity were obtained during stereotactic surgery for the implantation of DBS electrodes in seven idiopathic CD and 14 PD patients. The mean GPi neuronal firing rate recorded from CD patients was lower than that in PD patients ( P < 0.001; means ± SE: 71.4 ± 2.2 and 91.7 ± 3.0 Hz, respectively). Furthermore, GPi neurons fired in a more irregular pattern consisting of more frequent and longer pauses in CD compared with PD patients. When comparisons were done based on locations of recordings, these differences in firing rates and patterns were limited to the ventral portion of the GPi. In contrast, no difference in firing rate or pattern was observed in the globus pallidus externus between the two groups. These findings suggest that alterations in both firing rate and firing pattern may underlie the differing motor symptoms associated with these two movement disorders.

scholarly journals α-Synuclein-induced dysregulation of neuronal activity contributes to murine dopamine neuron vulnerability

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Abeer Dagra ◽  
Douglas R. Miller ◽  
Min Lin ◽  
Adithya Gopinath ◽  
Fatemeh Shaerzadeh ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neuronal Activity ◽  
Dopaminergic Neurons ◽  
Prolonged Exposure ◽  
D2 Receptor ◽  
Neuronal Firing ◽  
Dopamine Neurons ◽  
Loss Of Function ◽  
Therapeutic Implications

AbstractPathophysiological damages and loss of function of dopamine neurons precede their demise and contribute to the early phases of Parkinson’s disease. The presence of aberrant intracellular pathological inclusions of the protein α-synuclein within ventral midbrain dopaminergic neurons is one of the cardinal features of Parkinson’s disease. We employed molecular biology, electrophysiology, and live-cell imaging to investigate how excessive α-synuclein expression alters multiple characteristics of dopaminergic neuronal dynamics and dopamine transmission in cultured dopamine neurons conditionally expressing GCaMP6f. We found that overexpression of α-synuclein in mouse (male and female) dopaminergic neurons altered neuronal firing properties, calcium dynamics, dopamine release, protein expression, and morphology. Moreover, prolonged exposure to the D2 receptor agonist, quinpirole, rescues many of the alterations induced by α-synuclein overexpression. These studies demonstrate that α-synuclein dysregulation of neuronal activity contributes to the vulnerability of dopaminergic neurons and that modulation of D2 receptor activity can ameliorate the pathophysiology. These findings provide mechanistic insights into the insidious changes in dopaminergic neuronal activity and neuronal loss that characterize Parkinson’s disease progression with significant therapeutic implications.

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