scholarly journals Subthalamic nucleus neuronal firing rate increases with Parkinson's disease progression

2011 ◽  
Vol 26 (9) ◽  
pp. 1657-1662 ◽  
Author(s):  
Michael S. Remple ◽  
Courtney H. Bradenham ◽  
C. Chris Kao ◽  
P. David Charles ◽  
Joseph S. Neimat ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Firing Rate ◽  
Disease Progression ◽  
Subthalamic Nucleus ◽  
Neuronal Firing ◽  
Neuronal Firing Rate

Subthalamic Nucleus Neuronal Firing Rate Increases with Parkinson's Disease Progression

Neurosurgery ◽  
2009 ◽  
Vol 65 (2) ◽  
pp. 422-422
Author(s):  
Michael S. Remple ◽  
Courtney H. Hayes ◽  
Chang Qing Kao ◽  
P. David Charles ◽  
Joseph Samir Neimat ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Firing Rate ◽  
Disease Progression ◽  
Subthalamic Nucleus ◽  
Neuronal Firing ◽  
Neuronal Firing Rate

Changes in neuronal firing rate in the subthalamic nucleus with Parkinson's disease

2012 ◽  
Vol 27 (3) ◽  
pp. 455-456 ◽  
Author(s):  
Michael S. Remple ◽  
Courtney H. Bradenham ◽  
C. Chris Kao ◽  
P. David Charles ◽  
Joseph S. Neimat ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Firing Rate ◽  
Subthalamic Nucleus ◽  
Neuronal Firing ◽  
Neuronal Firing Rate

scholarly journals Asymmetry of Subthalamic Neuronal Firing Rate and Oscillatory Characteristics in Parkinson’s Disease [Retraction]

2020 ◽  
Vol Volume 16 ◽  
pp. 975-976
Author(s):  
Xue-Min Zhao ◽  
Ping Zhuang ◽  
Yong-jie Li ◽  
Yu-qing Zhang ◽  
Jian-yu Li ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Firing Rate ◽  
Neuronal Firing ◽  
Neuronal Firing Rate

scholarly journals Asymmetry of Subthalamic Neuronal Firing Rate and Oscillatory Characteristics in Parkinson’s Disease

2020 ◽  
Vol Volume 16 ◽  
pp. 313-323
Author(s):  
Xue-Min Zhao ◽  
Ping Zhuang ◽  
Yong-jie Li ◽  
Yu-qing Zhang ◽  
Jian-yu Li ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Firing Rate ◽  
Neuronal Firing ◽  
Neuronal Firing Rate

The potential neuromodulatory impact of subthalamic nucleus deep brain stimulation on Parkinson’s disease progression

2020 ◽  
Vol 73 ◽  
pp. 150-154
Author(s):  
Stanislaw Szlufik ◽  
Karolina Duszynska-Lysak ◽  
Andrzej Przybyszewski ◽  
Ilona Laskowska-Levy ◽  
Agnieszka Drzewinska ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Disease Progression ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Deep Brain

Internal Pallidal Neuronal Activity During Mild Drug-Related Dyskinesias in Parkinson's Disease: Decreased Firing Rates and Altered Firing Patterns

2007 ◽  
Vol 97 (4) ◽  
pp. 2627-2641 ◽  
Author(s):  
J. I. Lee ◽  
L. Verhagen Metman ◽  
S. Ohara ◽  
P. M. Dougherty ◽  
J. H. Kim ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Firing Rate ◽  
Spike Trains ◽  
Neuronal Firing ◽  
Low Doses ◽  
Significant Group ◽  
Firing Patterns ◽  
Firing Rates ◽  
Before And After

The neuronal basis of hyperkinetic movement disorders has long been unclear. We now test the hypothesis that changes in the firing pattern of neurons in the globus pallidus internus (GPi) are related to dyskinesias induced by low doses of apomorphine in patients with advanced Parkinson's disease (PD). During pallidotomy for advanced PD, the activity of single neurons was studied both before and after administration of apomorphine at doses just adequate to induce dyskinesias (21 neurons, 17 patients). After the apomorphine injection, these spike trains demonstrated an initial fall in firing from baseline. In nine neurons, the onset of on was simultaneous with that of dyskinesias. In these spike trains, the initial fall in firing rate preceded and was larger than the fall at the onset of on with dyskinesias. Among the three neurons in which the onset of on occurred before that of dyskinesias, the firing rate did not change at the time of onset of dyskinesias. After injection of apomorphine, dyskinesias during on with dyskinesias often fluctuated between transient periods with dyskinesias and those without. Average firing rates were not different between these two types of transient periods. Transient periods with dyskinesias were characterized by interspike interval (ISI) independence, stationary spike trains, and higher variability of ISIs. A small but significant group of neurons demonstrated recurring ISI patterns during transient periods of on with dyskinesias. These results suggest that mild dyskinesias resulting from low doses of apomorphine are related to both low GPi neuronal firing rates and altered firing patterns.

scholarly journals Multistable properties of human subthalamic nucleus neurons in Parkinson’s disease

2019 ◽  
Vol 116 (48) ◽  
pp. 24326-24333 ◽  
Author(s):  
Jeremy W. Chopek ◽  
Hans Hultborn ◽  
Robert M. Brownstone
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Nucleus ◽  
Neural Circuits ◽  
Silent Period ◽  
Neuronal Firing ◽  
Awake Surgery ◽  
Finite State ◽  
Subthalamic Neurons ◽  
Firing Properties

To understand the function and dysfunction of neural circuits, it is necessary to understand the properties of the neurons participating in the behavior, the connectivity between these neurons, and the neuromodulatory status of the circuits at the time they are producing the behavior. Such knowledge of human neural circuits is difficult, at best, to obtain. Here, we study firing properties of human subthalamic neurons, using microelectrode recordings and microstimulation during awake surgery for Parkinson’s disease. We demonstrate that low-amplitude, brief trains of microstimulation can lead to persistent changes in neuronal firing behavior including switching between firing rates, entering silent periods, or firing several bursts then entering a silent period. We suggest that these multistable states reflect properties of finite state machines and could have implications for the function of circuits involving the subthalamic nucleus. Furthermore, understanding these states could lead to therapeutic strategies aimed at regulating the transitions between states.

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