scholarly journals BDNF and the Antidepressant Effects of Ketamine and Propofol in Electroconvulsive Therapy: A Preliminary Study

2020 ◽  
Vol Volume 16 ◽  
pp. 901-908 ◽  
Author(s):  
Xing-Bing Huang ◽  
Xiong Huang ◽  
Hong-Bo He ◽  
Fang Mei ◽  
Bin Sun ◽  
...  
Keyword(s):  
Electroconvulsive Therapy ◽  
Antidepressant Effects ◽  
Preliminary Study

scholarly journals Serum BDNF levels and the antidepressant effects of electroconvulsive therapy with ketamine anaesthesia: a preliminary study

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e10699
Author(s):  
Wei Zheng ◽  
Qiaomei Cen ◽  
Sha Nie ◽  
Minyi Li ◽  
Rong Zeng ◽  
...  
Keyword(s):  
Electroconvulsive Therapy ◽  
Rating Scale ◽  
Enzyme Linked Immunosorbent Assay ◽  
Healthy Controls ◽  
Antidepressant Response ◽  
Baseline Serum ◽  
Ketamine Anaesthesia ◽  
Antidepressant Effects ◽  
Preliminary Study ◽  
Serum Bdnf

Objective To firstly examine the relationship between serum brain-derived neurotrophic factor (BDNF) levels and antidepressant response to ketamine as an anaesthesia in electroconvulsive therapy (ECT) in Chinese patients with treatment-refractory depression (TRD). Methods Thirty patients with TRD were enrolled and underwent eight ECT sessions with ketamine anaesthesia (0.8 mg/kg) alone. Depression severity, response and remission were evaluated using the 17-item Hamilton Depression Rating Scale (HAMD-17). Enzyme-linked immunosorbent assay (ELISA) was applied to examine serum BDNF levels in patients with TRD at baseline and after the second, fourth and eighth ECT sessions. Baseline serum samples were also collected for 30 healthy controls. Results No significant differences were observed in serum BDNF levels between patients with TRD and healthy controls at baseline (p > 0.05). The remission rate was 76.7% (23/30) after the last ECT treatment, although all patients with TRD obtained antidepressant response criteria. Serum BDNF levels were not altered compared to baseline, even between remitters and nonremitters (all p > 0.05), despite the significant reduction in HAMD-17 and Brief Psychiatric Rating Scale (BPRS) scores after ECT with ketamine anaesthesia (all p < 0.05). The antidepressant effects of ECT with ketamine anaesthesia were not correlated with changes in serum BDNF levels (all p > 0.05). Conclusion This preliminary study indicated that serum BDNF levels do not appear to be a reliable biomarker to determine the antidepressant effects of ketamine as an anaesthesia in ECT for patients with TRD. Further studies with larger sample sizes are warranted to confirm these findings.

scholarly journals Antidepressant effects of electroconvulsive therapy.

BMJ ◽  
1983 ◽  
Vol 286 (6375) ◽  
pp. 1443-1443 ◽  
Author(s):  
C L Katona ◽  
C R Aldridge
Keyword(s):  
Electroconvulsive Therapy ◽  
Antidepressant Effects

The Onset and Rate of the Antidepressant Effect of Electroconvulsive Therapy

1993 ◽  
Vol 162 (6) ◽  
pp. 725-732 ◽  
Author(s):  
Allan I. F. Scott ◽  
Lawrence J. Whalley
Keyword(s):  
Electroconvulsive Therapy ◽  
Royal College ◽  
Mode Of Action ◽  
Depressive Disorders ◽  
Practical Interest ◽  
Antidepressant Effect ◽  
Rapid Improvement ◽  
Research Committee ◽  
Biological Studies ◽  
Antidepressant Effects

This annotation is concerned with how soon and at what rate antidepressant effects become apparent over a course of electroconvulsive therapy (ECT). The first question is of importance in the design and interpretation of biological studies of the mode of action of ECT. The second question is of practical interest to the treating psychiatrist when we ask how the speed of recovery is influenced by what the psychiatrist prescribes, that is, the number and frequency of treatments. These questions are little better answered now than 20 years ago. This may come as a surprise to many readers, who have been advised to use ECT when “seeking rapid improvement” in depressive disorders (ECT Sub-Committee of the Research Committee of the Royal College of Psychiatrists, 1989). This lack of progress is attributable to a dearth of appropriately designed ECT studies.

Stability and predictive value of self-report personality traits pre- and post-electroconvulsive therapy: A preliminary study

1998 ◽  
Vol 39 (4) ◽  
pp. 231-235 ◽  
Author(s):  
Mark A Blais ◽  
John Matthews ◽  
Ronald Schouten ◽  
Sheila M O'Keefe ◽  
Paul Summergrad
Keyword(s):  
Personality Traits ◽  
Electroconvulsive Therapy ◽  
Predictive Value ◽  
Self Report ◽  
Preliminary Study

scholarly journals Hippocampal-subregion functional alterations associated with antidepressant effects and cognitive impairments of electroconvulsive therapy

2018 ◽  
Vol 49 (08) ◽  
pp. 1357-1364 ◽  
Author(s):  
Tongjian Bai ◽  
Qiang Wei ◽  
Wen Xie ◽  
Anzhen Wang ◽  
Jiaojian Wang ◽  
...  
Keyword(s):  
Electroconvulsive Therapy ◽  
Rating Scale ◽  
Cognitive Impairments ◽  
Structural Connectivity ◽  
Angular Gyrus ◽  
Resting State Functional Connectivity ◽  
Antidepressant Effects ◽  
Emotion And Memory ◽  
Middle Occipital Gyrus ◽  
The Relationship

AbstractBackgroundElectroconvulsive therapy (ECT), an effective antidepressive treatment, is frequently accompanied by cognitive impairment (predominantly memory), usually transient and self-limited. The hippocampus is a key region involved in memory and emotion processing, and in particular, the anterior-posterior hippocampal subregions has been shown to be associated with emotion and memory. However, less is known about the relationship between hippocampal-subregion alterations following ECT and antidepressant effects or cognitive impairments.MethodsResting-state functional connectivity (RSFC) based on the seeds of hippocampal subregions were investigated in 45 pre- and post-ECT depressed patients. Structural connectivity between hippocampal subregions and corresponding functionally abnormal regions was also conducted using probabilistic tractography. Antidepressant effects and cognitive impairments were measured by the Hamilton Depressive Rating Scale (HDRS) and the Category Verbal Fluency Test (CVFT), respectively. Their relationships with hippocampal-subregions alterations were examined.ResultsAfter ECT, patients showed increased RSFC in the hippocampal emotional subregion (HIPe) with the left middle occipital gyrus (LMOG) and right medial temporal gyrus (RMTG). Decreased HDRS was associated with increased HIPe-RMTG RSFC (r = −0.316, p = 0.035) significantly and increased HIPe-LMOG RSFC at trend level (r = −0.283, p = 0.060). In contrast, the hippocampal cognitive subregion showed decreased RSFC with the bilateral angular gyrus, and was correlated with decreased CVFT (r = 0.418, p = 0.015 for left; r = 0.356, p = 0.042 for right). No significant changes were found in structural connectivity.ConclusionThe hippocampal-subregions functional alterations may be specially associated with the antidepressant and cognitive effects of ECT.

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