scholarly journals Improvement Of Frontal Lobe Dysfunction And White Matter Integrity By rTMS In Treatment-Resistant Depression

2019 ◽  
Vol Volume 15 ◽  
pp. 3079-3087
Author(s):  
Hiroshi Tateishi ◽  
Masashi Nishihara ◽  
Atsushi Kawaguchi ◽  
Jun Matsushima ◽  
Toru Murakawa ◽  
...  
Keyword(s):  
White Matter ◽  
Frontal Lobe ◽  
White Matter Integrity ◽  
Frontal Lobe Dysfunction ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression

scholarly journals Structural brain characteristics in treatment-resistant depression: review of magnetic resonance imaging studies

BJPsych Open ◽  
2019 ◽  
Vol 5 (5) ◽  
Author(s):  
Margit Philomène C. Klok ◽  
Philip. F. van Eijndhoven ◽  
Miklos Argyelan ◽  
Aart H. Schene ◽  
Indira Tendolkar
Keyword(s):  
White Matter ◽  
Anterior Cingulate ◽  
Cochrane Library ◽  
Precentral Gyrus ◽  
Healthy Controls ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Brain Changes ◽  
Resistant Depression ◽  
Structural Brain

Background Major depressive disorder (MDD) has been related to structural brain characteristics that are correlated with the severity of disease. However, the correlation of these structural changes is less well clarified in treatment-resistant depression (TRD). Aims To summarise the existing literature on structural brain characteristics in TRD to create an overview of known abnormalities of the brain in patients with MDD, to form hypotheses about the absence or existence of a common pathophysiology of MDD and TRD. Method A systematic search of PubMed and the Cochrane Library for studies published between 1998 and August of 2016 investigating structural brain changes in patients with TRD compared with healthy controls or patients with MDD. Results Fourteen articles are included in this review. Lower grey matter volume (GMV) in the anterior cingulate cortex, right cerebellum, caudate nucleus, superior/medial frontal gyrus and hippocampus does not seem to differentiate TRD from milder forms of MDD. However, lower GMV in the putamen, inferior frontal gyrus, precentral gyrus, angular- and post-central gyri together with specific mainly parietal white matter tract changes seem to be more specific structural characteristics of TRD. Conclusions The currently available data on structural brain changes in patients with TRD compared with milder forms of MDD and healthy controls cannot sufficiently distinguish between a ‘shared continuum hypothesis’ and a ‘different entity hypothesis’. Our review clearly suggests that although there is some overlap in affected brain regions between milder forms of MDD and TRD, TRD also comes with specific alterations in mainly the putamen and parietal white matter tracts. Declaration of interest None.

The Role of White Matter Abnormalities in Treatment-Resistant Depression: A Systematic Review

2015 ◽  
Vol 21 (10) ◽  
pp. 1337-1346 ◽  
Author(s):  
Gianluca Serafini ◽  
Maurizio Pompili ◽  
Stefan Borgwardt ◽  
Enrico Giuffra ◽  
Oliver Howes ◽  
...  
Keyword(s):  
Systematic Review ◽  
White Matter ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
White Matter Abnormalities ◽  
Resistant Depression

scholarly journals Changes in White Matter Microstructure After Electroconvulsive Therapy for Treatment-Resistant Depression

2019 ◽  
Vol 23 (1) ◽  
pp. 20-25
Author(s):  
Gregor Gryglewski ◽  
René Seiger ◽  
Pia Baldinger-Melich ◽  
Jakob Unterholzner ◽  
Benjamin Spurny ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Electroconvulsive Therapy ◽  
Electrode Placement ◽  
Treatment Resistant Depression ◽  
Resonance Imaging ◽  
Treatment Resistant ◽  
White Matter Microstructure ◽  
Resistant Depression ◽  
The Right

Abstract Background Treatment-resistant depression is among the most debilitating conditions in psychiatry. Recent studies have associated alterations in white matter microstructure measured with magnetic resonance imaging with poor antidepressant response. Therefore, the extent to which electroconvulsive therapy, the most effective therapeutic option for treatment-resistant depression, affects white matter microstructure warrants investigation. Methods A total 13 patients suffering from severe unipolar treatment-resistant depression underwent magnetic resonance imaging with a diffusion tensor imaging sequence before and after undergoing a series of right unilateral electroconvulsive therapy. Diffusivity metrics were compared voxel-wise using tract-based spatial statistics and repeated-measures ANOVA. Results A total 12 patients responded to electroconvulsive therapy and 9 were classified as remitters. An increase in axial diffusivity was observed in the posterior limb of the internal capsule of the right hemisphere (PFWE ≤ .05). The increase in this area was higher in the right compared with the left hemisphere (P < .05). No correlation of this effect with treatment response could be found. Conclusions The strong lateralization of effects to the hemisphere of electrical stimulation suggests an effect of electroconvulsive therapy on diffusivity metrics which is dependent of electrode placement. Investigation in controlled studies is necessary to reveal to what extent the effects of electroconvulsive therapy on white matter microstructure are related to clinical outcomes and electrode placement.

scholarly journals Defining Critical White Matter Pathways Mediating Successful Subcallosal Cingulate Deep Brain Stimulation for Treatment-Resistant Depression

2014 ◽  
Vol 76 (12) ◽  
pp. 963-969 ◽  
Author(s):  
Patricio Riva-Posse ◽  
Ki Sueng Choi ◽  
Paul E. Holtzheimer ◽  
Cameron C. McIntyre ◽  
Robert E. Gross ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
White Matter ◽  
Brain Stimulation ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression ◽  
Deep Brain
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