scholarly journals Effects of repetitive magnetic stimulation on the growth of primarily cultured hippocampus neurons in vitro and their expression of iron-containing enzymes

2019 ◽  
Vol Volume 15 ◽  
pp. 927-934 ◽  
Author(s):  
Yirong Wang ◽  
Kewei Fang ◽  
Shijia He ◽  
Yang Fan ◽  
Juming Yu ◽  
...  
Keyword(s):  
Magnetic Stimulation ◽  
Repetitive Magnetic Stimulation

scholarly journals Repetitive low intensity magnetic field stimulation in a neuronal cell line: A metabolomics study

2018 ◽  
Author(s):  
Ivan Hong ◽  
Andrew Garrett ◽  
Garth Maker ◽  
Ian Mullaney ◽  
Jennifer Rodger ◽  
...  
Keyword(s):  
Cell Line ◽  
Magnetic Stimulation ◽  
Neuronal Excitability ◽  
Therapeutic Potential ◽  
Neuronal Cell ◽  
Neural Tissue ◽  
Gaba Release ◽  
Low Intensity ◽  
Repetitive Magnetic Stimulation

Low intensity repetitive magnetic stimulation of neural tissue modulates neuronal excitability and has promising therapeutic potential in the treatment of neurological disorders. However, the underpinning cellular and biochemical mechanisms remain poorly understood. This study investigates the behavioural effects of low intensity repetitive magnetic stimulation (LI-rMS) at a cellular and biochemical level. We delivered LI-rMS (10 mT) at 1 Hz and 10 Hz (n=5 wells per group) to B50 rat neuroblastoma cells in vitro for 10 minutes and measured levels of selected metabolites immediately after stimulation. LI-rMS at both frequencies depleted selected tricarboxylic acid (TCA) cycle metabolites without affecting the main energy supplies. Furthermore, LI-rMS effects were frequency-specific with 1 Hz stimulation having stronger effects than 10 Hz. The observed depletion of metabolites was consistent with an increase in GABA release as a result of higher spontaneous activity. Although the absence of organised neural circuits and other cellular contributors (e.g. excitatory neurons and glia) in the B50 cell line limits the degree to which our results can be extrapolated to the human brain, the changes we describe provide novel insights into how LI-rMS modulates neural tissue.

scholarly journals Repetitive low intensity magnetic field stimulation in a neuronal cell line: a metabolomics study

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4501 ◽  
Author(s):  
Ivan Hong ◽  
Andrew Garrett ◽  
Garth Maker ◽  
Ian Mullaney ◽  
Jennifer Rodger ◽  
...  
Keyword(s):  
Cell Line ◽  
Magnetic Stimulation ◽  
Neuronal Excitability ◽  
Therapeutic Potential ◽  
Neuronal Cell ◽  
Neural Tissue ◽  
Gaba Release ◽  
Low Intensity ◽  
Repetitive Magnetic Stimulation

Low intensity repetitive magnetic stimulation of neural tissue modulates neuronal excitability and has promising therapeutic potential in the treatment of neurological disorders. However, the underpinning cellular and biochemical mechanisms remain poorly understood. This study investigates the behavioural effects of low intensity repetitive magnetic stimulation (LI-rMS) at a cellular and biochemical level. We delivered LI-rMS (10 mT) at 1 Hz and 10 Hz to B50 rat neuroblastoma cellsin vitrofor 10 minutes and measured levels of selected metabolites immediately after stimulation. LI-rMS at both frequencies depleted selected tricarboxylic acid (TCA) cycle metabolites without affecting the main energy supplies. Furthermore, LI-rMS effects were frequency-specific with 1 Hz stimulation having stronger effects than 10 Hz. The observed depletion of metabolites suggested that higher spontaneous activity may have led to an increase in GABA release. Although the absence of organised neural circuits and other cellular contributors (e.g., excitatory neurons and glia) in the B50 cell line limits the degree to which our results can be extrapolated to the human brain, the changes we describe provide novel insights into how LI-rMS modulates neural tissue.

scholarly journals Repetitive low intensity magnetic field stimulation in a neuronal cell line: A metabolomics study

2018 ◽  
Author(s):  
Ivan Hong ◽  
Andrew Garrett ◽  
Garth Maker ◽  
Ian Mullaney ◽  
Jennifer Rodger ◽  
...  
Keyword(s):  
Cell Line ◽  
Magnetic Stimulation ◽  
Neuronal Excitability ◽  
Therapeutic Potential ◽  
Neuronal Cell ◽  
Neural Tissue ◽  
Gaba Release ◽  
Low Intensity ◽  
Repetitive Magnetic Stimulation

Low intensity repetitive magnetic stimulation of neural tissue modulates neuronal excitability and has promising therapeutic potential in the treatment of neurological disorders. However, the underpinning cellular and biochemical mechanisms remain poorly understood. This study investigates the behavioural effects of low intensity repetitive magnetic stimulation (LI-rMS) at a cellular and biochemical level. We delivered LI-rMS (10 mT) at 1 Hz and 10 Hz (n=5 wells per group) to B50 rat neuroblastoma cells in vitro for 10 minutes and measured levels of selected metabolites immediately after stimulation. LI-rMS at both frequencies depleted selected tricarboxylic acid (TCA) cycle metabolites without affecting the main energy supplies. Furthermore, LI-rMS effects were frequency-specific with 1 Hz stimulation having stronger effects than 10 Hz. The observed depletion of metabolites was consistent with an increase in GABA release as a result of higher spontaneous activity. Although the absence of organised neural circuits and other cellular contributors (e.g. excitatory neurons and glia) in the B50 cell line limits the degree to which our results can be extrapolated to the human brain, the changes we describe provide novel insights into how LI-rMS modulates neural tissue.

Repetitive Magnetic Stimulation of Neck Muscles in Patients with Migraine

2016 ◽  
Vol 47 (S 01) ◽  
Author(s):  
N. Sollmann ◽  
F. Trepte-Freisleder ◽  
F. Heinen ◽  
S. Krieg ◽  
M. Landgraf
Keyword(s):  
Magnetic Stimulation ◽  
Neck Muscles ◽  
Repetitive Magnetic Stimulation ◽  
Stimulation Of
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