scholarly journals The efficacy and safety of multiple doses of vortioxetine for generalized anxiety disorder: a meta-analysis

2016 ◽  
pp. 951 ◽  
Author(s):  
Jie Fu ◽  
Lilei Peng ◽  
Xiaogang Li
Keyword(s):  
Anxiety Disorder ◽  
Generalized Anxiety Disorder ◽  
Meta Analysis ◽  
Generalized Anxiety ◽  
Efficacy And Safety ◽  
Multiple Doses

scholarly journals Efficacy and Safety of a Formulated Herbal Granula, Jiu Wei Zhen Xin, for Generalized Anxiety Disorder: A Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Sheng Wang ◽  
Lin-lin Zhao ◽  
Xin-jian Qiu ◽  
Dong-sheng Wang ◽  
Tao Tang ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Adverse Events ◽  
Generalized Anxiety Disorder ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Rating Scale ◽  
Meta Analysis ◽  
Pooled Analysis ◽  
Generalized Anxiety ◽  
Efficacy And Safety ◽  
Significant Difference

Background. The traditional Chinese medicine formula Jiu Wei Zhen Xin Granula (JWZXG) is prescribed to treat generalized anxiety disorder (GAD) in China. This study was to assess the efficacy and safety of JWZXG in patients with GAD. Method. Data were pooled from 14 randomized controlled trials involving the assessment of mean changes of Hamilton Anxiety Rating Scale (HAMA) total scores, response rates, adverse event rates, quality, publication bias, and risk of bias. Results. Pooled analysis showed no significant difference in response rate (risk ratio 1.01, 95% CI [0.93–1.08]; Z test = 0.17, P=0.86) and no significant difference between JWZXG group and azapirones group (RR 0.69, 95% CI [0.45, 1.06]; Z test = 1.69, P=0.09) in rate of adverse events. Though no difference exists between JWZXG group and azapirones group in HAMA total score from baseline, JWZXG group was inferior to selective serotonin reuptake inhibitors (SSRIs) group (WMD −0.93, 95% CI [−1.64, −0.23]; Z test = 2.6, P=0.009) which had more adverse events than JWZXG group (RR 0.64, 95% CI [0.46, 0.89]; Z test = 2.63, P=0.009). Conclusions. This meta-analysis preliminarily suggests that JWZXG is as effective as azapirones, though having the same possibility of suffering AEs. JWZXG was inferior to SSRIs but causes fewer AEs in the treatment of GAD.

scholarly journals Efficacy and tolerability of short-term duloxetine treatment in adults with generalized anxiety disorder: A meta-analysis

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0194501 ◽  
Author(s):  
Xinyuan Li ◽  
Lijun Zhu ◽  
Chunkui Zhou ◽  
Jing Liu ◽  
Heqian Du ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Generalized Anxiety Disorder ◽  
Meta Analysis ◽  
Generalized Anxiety ◽  
Short Term

scholarly journals The efficacy of antidepressants for generalized anxiety disorder: a systematic review and meta-analysis

2005 ◽  
Vol 27 (1) ◽  
pp. 18-24 ◽  
Author(s):  
Ricardo Schmitt ◽  
Fernando Kratz Gazalle ◽  
Maurício Silva de Lima ◽  
Ângelo Cunha ◽  
Juliano Souza ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Generalized Anxiety Disorder ◽  
Weighted Mean Difference ◽  
Meta Analysis ◽  
Generalized Anxiety ◽  
Number Needed To Treat ◽  
Relative Risks ◽  
Co Morbidity ◽  
Axis I ◽  
Calculated Number

OBJECTIVE: To investigate the efficacy and acceptability of antidepressants in the treatment of generalized anxiety disorder. METHODS: All randomized controlled trials assessing the use of antidepressants in generalized anxiety disorder up to may 2002 were included. Non randomized trials and those that included patients with both generalized anxiety disorder and another Axis I co-morbidity were excluded. Relative risks, weighted mean difference and number needed to treat were estimated. People who died or dropped out were regarded as having had no improvement. RESULTS: Antidepressants (imipramine, venlafaxine and paroxetine) were found to be superior to placebo in treating generalized anxiety disorder. The calculated number needed to treat for antidepressants in generalized anxiety disorder was 5.15. Dropout rates did not differ between antidepressants and placebo. CONCLUSION: The available evidence suggests that antidepressants would probably be a reasonable treatment for generalized anxiety disorder patients in the clinical context.

scholarly journals Digital Interventions for Generalized Anxiety Disorder (GAD): Systematic Review and Network Meta-Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Pedro Saramago ◽  
Lina Gega ◽  
David Marshall ◽  
Georgios F. Nikolaidis ◽  
Dina Jankovic ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Generalized Anxiety Disorder ◽  
Meta Analysis ◽  
Antidepressant Medication ◽  
Generalized Anxiety ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Self Help ◽  
Digital Interventions ◽  
Better Than

Background: Generalized anxiety disorder is the most common mental health condition based on weekly prevalence. Digital interventions have been used as alternatives or as supplements to conventional therapies to improve access, patient choice, and clinical outcomes. Little is known about their comparative effectiveness for generalized anxiety disorder.Methods: We conducted a systematic review and network meta-analysis of randomized controlled trials comparing digital interventions with medication, non-digital interventions, non-therapeutic controls, and no intervention.Results: We included 21 randomized controlled trials with a total of 2,350 participants from generalized anxiety disorder populations. Pooled outcomes using analysis of Covariance and rankograms based on the surface under the cumulative ranking curves indicated that antidepressant medication and group therapy had a higher probability than digital interventions of being the “best” intervention. Supported digital interventions were not necessarily “better” than unsupported (pure self-help) ones.Conclusions: Due to very wide confidence intervals, network meta-analysis results were inconclusive as to whether digital interventions are better than no intervention and non-therapeutic active controls, or whether they confer an additional benefit to standard therapy. Future research needs to compare digital interventions with one-to-one therapy and with manualized non-digital self-help and to include antidepressant medication as a treatment comparator and effect modifier.

Efficacy and Safety of Vilazodone in Patients With Generalized Anxiety Disorder

2016 ◽  
Vol 77 (12) ◽  
pp. 1687-1694 ◽  
Author(s):  
Suresh Durgam ◽  
Carl Gommoll ◽  
Giovanna Forero ◽  
Rene Nunez ◽  
Xiongwen Tang ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Generalized Anxiety Disorder ◽  
Generalized Anxiety ◽  
Efficacy And Safety
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