scholarly journals Management of knee osteoarthritis by combined stromal vascular fraction cell therapy, platelet-rich plasma, and musculoskeletal exercises: a case series

2015 ◽  
pp. 799 ◽  
Author(s):  
Nathan Gibbs ◽  
Rod Diamond ◽  
Eric Sekyere ◽  
Wayne Thomas
Keyword(s):  
Cell Therapy ◽  
Knee Osteoarthritis ◽  
Platelet Rich Plasma ◽  
Stromal Vascular Fraction ◽  
Case Series ◽  
Stromal Vascular Fraction Cell

Treating Knee Osteoarthritis With Platelet-Rich Plasma and Hyaluronic Acid Combination Therapy: A Systematic Review

2021 ◽  
pp. 036354652199801
Author(s):  
Michael R. Baria ◽  
W. Kelton Vasileff ◽  
James Borchers ◽  
Alex DiBartola ◽  
David C. Flanigan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Hyaluronic Acid ◽  
Combination Therapy ◽  
Knee Osteoarthritis ◽  
Platelet Rich Plasma ◽  
Case Series ◽  
Final Analysis ◽  
Preparation Technique ◽  
Randomized Studies ◽  
Patient Reported

Background: Platelet-rich plasma (PRP) and hyaluronic acid (HA) are injectable treatments for knee osteoarthritis. The focus of previous studies has compared their efficacy against each other as monotherapy. However, a new trend of combining these 2 injections has emerged in an attempt to have a synergistic effect. Purpose: To systematically review the clinical literature examining the combined use of PRP + HA. Design: Systematic review. Methods: A systematic review was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines using PubMed and Embase. The following search terms were used: knee osteoarthritis AND platelet rich plasma AND hyaluronic acid. The review was performed by 2 independent reviewers who applied the inclusion/exclusion criteria and independently extracted data, including methodologic scoring, PRP preparation technique, HA composition, and patient-reported outcomes (PROs). Results: A total of 431 articles were screened, 12 reviewed in full, and 8 included in the final analysis: 2 case series, 3 comparative, and 3 randomized studies. Average follow-up was 9 months. The modified Coleman Methodology Score was 38.13 ± 13.1 (mean ± SD). Combination therapy resulted in improved PROs in all studies. Of the comparative and randomized studies, 2 demonstrated that combination therapy was superior to HA alone. However, when PRP alone was used as the control arm (4 studies), combination therapy was not superior to PRP alone. Conclusion: Combination therapy with PRP + HA improves PROs and is superior to HA alone but is not superior to PRP alone.

scholarly journals Stromal vascular fraction cell therapy for osteoarthritis in elderly: Multicenter case-control study

2019 ◽  
Vol 10 (1) ◽  
pp. 76-80 ◽  
Author(s):  
Jaroslav Michalek ◽  
Alena Vrablikova ◽  
Adas Darinskas ◽  
Ladislav Lukac ◽  
Jaroslav Prucha ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Case Control Study ◽  
Stromal Vascular Fraction ◽  
Case Control ◽  
Stromal Vascular Fraction Cell ◽  
Control Study

scholarly journals Knee Osteoarthritis: A Review of Pathogenesis and State-Of-The-Art Non-Operative Therapeutic Considerations

Genes ◽  
2020 ◽  
Vol 11 (8) ◽  
pp. 854
Author(s):  
Dragan Primorac ◽  
Vilim Molnar ◽  
Eduard Rod ◽  
Željko Jeleč ◽  
Fabijan Čukelj ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Platelet Rich Plasma ◽  
Treatment Options ◽  
Stromal Vascular Fraction ◽  
Disease Stage ◽  
Knee Oa ◽  
Marrow Mesenchymal Stem Cells ◽  
The Moment ◽  
And Function ◽  
Orthopedic Patients

Being the most common musculoskeletal progressive condition, osteoarthritis is an interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) among adults 60 years of age or older is approximately 10% in men and 13% in women, making knee OA one of the leading causes of disability in elderly population. Today, we know that osteoarthritis is not a disease characterized by loss of cartilage due to mechanical loading only, but a condition that affects all of the tissues in the joint, causing detectable changes in tissue architecture, its metabolism and function. All of these changes are mediated by a complex and not yet fully researched interplay of proinflammatory and anti-inflammatory cytokines, chemokines, growth factors and adipokines, all of which can be measured in the serum, synovium and histological samples, potentially serving as biomarkers of disease stage and progression. Another key aspect of disease progression is the epigenome that regulates all the genetic expression through DNA methylation, histone modifications, and mRNA interference. A lot of work has been put into developing non-surgical treatment options to slow down the natural course of osteoarthritis to postpone, or maybe even replace extensive surgeries such as total knee arthroplasty. At the moment, biological treatments such as platelet-rich plasma, bone marrow mesenchymal stem cells and autologous microfragmented adipose tissue containing stromal vascular fraction are ordinarily used. Furthermore, the latter two mentioned cell-based treatment options seem to be the only methods so far that increase the quality of cartilage in osteoarthritis patients. Yet, in the future, gene therapy could potentially become an option for orthopedic patients. In the following review, we summarized all of the latest and most important research in basic sciences, pathogenesis, and non-operative treatment.

scholarly journals Fresh autologous stromal tissue fraction for the treatment of knee osteoarthritis related pain and disability

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Stefano Santoprete ◽  
Federica Marchetti ◽  
Carlotta Rubino ◽  
Maria Grazie Bedini ◽  
Luigi Aurelio Nasto ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Adult Population ◽  
Stromal Vascular Fraction ◽  
Case Series ◽  
Cartilage Degradation ◽  
Womac Pain ◽  
Score Change ◽  
Anabolic Action ◽  
Stromal Tissue ◽  
Tissue Fraction

Knee osteoarthritis (KOA) is a very common condition with multifactorial etiology leading to severe pain and disability in the adult population. Although KOA is considered a non-inflammatory arthritis, upregulation of inflammatory and catabolic pathways with increased production of proinflammatory cytokines leading to cartilage degradation and extracellular matrix degeneration has been reported. Intra-articular injection of fresh fat derived stromal vascular fraction (SVF) fraction has been proposed as a valid and alternative treatment for symptomatic KOA that guarantees mechanical support through viscosupplementation, anti-inflammatory, and anabolic action. We retrospectively reviewed a case series of 84 consecutive adult patients with KOA who underwent intra-articular injection of fresh fat derived SVF. Significant improvement in pain levels (NRS score decrease 3.5±1.1, p<0.001), WOMAC pain (-7.02±3.45 score change, p<0.001), WOMAC stiffness (-1.97±1.02, p<0.001), and ROM improvement (+17.13±5.22°, p<0.001). The only complication noted was knee joint swelling lasting for less than 7 days after the injection in 7% of the patients.

scholarly journals Treatment of Grade 3 and 4 Osteoarthritis with Intraoperatively Separated Adipose Tissue-Derived Stromal Vascular Fraction: A Comparative Case Series

Cells ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 2096
Author(s):  
Denis Simunec ◽  
Honey Salari ◽  
Juliane Meyer
Keyword(s):  
Adipose Tissue ◽  
Platelet Rich Plasma ◽  
Subjective Evaluation ◽  
Stromal Vascular Fraction ◽  
Case Series ◽  
Joint Space ◽  
Substantial Improvement ◽  
Serious Adverse Events ◽  
Artificial Joint Replacement ◽  
Grade 3

Osteoarthritis (OA) is the most common form of arthritis of the joints. The stromal vascular fraction (SVF) is a regenerative cell population that can be isolated from adipose tissue. It is the immunomodulatory properties of the stromal vascular fraction that make it a promising candidate for the regenerative treatment of OA. Patients with grade 3 and 4 osteoarthritis were treated with the stromal vascular fraction with and without platelet-rich plasma (PRP) and followed up on their Knee Injury and Osteoarthritis Outcome Score (KOOS) score for 12 months, with MRI and subjective evaluation of the procedure. Magnetic resonance imaging (MRI) revealed a widening of the joint space, a restructuring of the cartilage, and an alleviation of effusions in the treated joints. In three of the four treatment groups, a substantial improvement of the KOOS scores was documented at the 12-month follow-up time point. According to the subjective evaluation, 67% of the patients were satisfied or very satisfied with the procedure and would recommend it to others. No serious adverse events or unwanted side effects related to the SVF treatment were observed or reported. Prior to an invasive artificial joint replacement, the treatment of arthritic knee joints with the intraarticular injection of autologous adipose tissue-derived SVF should be considered a regenerative treatment option.

scholarly journals Efficacy of Intra-Articular Injection of Platelet Rich Plasma and Hyaluronic Acid in Early Knee Osteoarthritis – Case Series

2018 ◽  
Vol 5 (1) ◽  
pp. 30-36 ◽  
Author(s):  
Krishnaiah Kurapati ◽  
Sanjay Tapadia ◽  
Madhusudhan Rao ◽  
Kavitha Anbarasu ◽  
Vinod Kumar Verma ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Knee Osteoarthritis ◽  
Platelet Rich Plasma ◽  
Case Series

Platelet rich plasma, stromal vascular fraction and autologous conditioned serum in treatment of knee osteoarthritis

2018 ◽  
Vol 104 ◽  
pp. 652-660 ◽  
Author(s):  
Ali Fotouhi ◽  
Arash Maleki ◽  
Sanam Dolati ◽  
Ali Aghebati-Maleki ◽  
Leili Aghebati-Maleki
Keyword(s):  
Knee Osteoarthritis ◽  
Platelet Rich Plasma ◽  
Stromal Vascular Fraction ◽  
Autologous Conditioned Serum

scholarly journals Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis

2009 ◽  
Vol 7 (1) ◽  
pp. 29 ◽  
Author(s):  
Neil H Riordan ◽  
Thomas E Ichim ◽  
Wei-Ping Min ◽  
Hao Wang ◽  
Fabio Solano ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cell Therapy ◽  
Stromal Vascular Fraction ◽  
Stromal Vascular Fraction Cell

scholarly journals Autologous stromal vascular fraction cells combined with platelet-rich plasma for androgenic alopecia treatment: a case series

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 408
Author(s):  
Fonny Josh ◽  
Tomie Hermawan Soekamto ◽  
Muhammad Faruk
Keyword(s):  
Platelet Rich Plasma ◽  
Treatment Options ◽  
Stromal Vascular Fraction ◽  
Case Series ◽  
Androgenic Alopecia ◽  
Case Presentation ◽  
Therapeutic Outcomes ◽  
Multipotent Cells ◽  
Combined Use

Background: Stromal vascular fraction cells (SVFs), which can be produced using a mechanical or digestive enzymatic process, are heterogeneous cells with the potential to grow hair in androgenic alopecia patients. Platelet-rich plasma (PRP) is an autologous cell source that is widely used to treat androgenic alopecia. However, the combined use of PRP and SVFs to treat alopecia is rarely reported. Case presentation: This case series describes three cases of androgenic alopecia, including a32-year-old male, a 43-year-old male, and a 65-year-old male. Androgenic alopecia in these patients was treated by injecting the bald area of the scalp with local autologous PRP combined with SVFs. Follow-up was performed 1–3 months after treatment, which showed good results. The hair grew denser, with increased thickness for each strand. The hair pull test revealed that the hair remained intact. Conclusion: The combination of PRP and SVFs affected all cycles of the hair growth process. SVFs are multipotent cells with the potential to become antioxidant, anti-inflammatory, or anti-fibrotic cells. SVFs can regenerate cells that secrete the growth factors, that are essential for angiogenesis, which can improve therapeutic outcomes. This case series will enrich the existing literature by expanding available treatment options for androgenic alopecia.

scholarly journals A Retrospective Study of Stromal Vascular Fraction Cell Therapy for Osteoarthritis

2020 ◽  
Vol 12 (11) ◽  
pp. 747-751
Author(s):  
Brian Mehling ◽  
Milan Hric ◽  
Adriana Salatkova ◽  
Robert Vetrak ◽  
Doreen Santora ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Cell Therapy ◽  
Stromal Vascular Fraction ◽  
Stromal Vascular Fraction Cell
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