scholarly journals Evidence for the endothelin system as an emerging therapeutic target for the treatment of chronic pain

2014 ◽  
pp. 531 ◽  
Author(s):  
Terika Smith ◽  
Tami Haymond ◽  
Sherika Smith ◽  
Sarah Sweitzer
Keyword(s):  
Chronic Pain ◽  
Therapeutic Target ◽  
Endothelin System

scholarly journals Sleep spindles as a diagnostic and therapeutic target for chronic pain

2020 ◽  
Vol 16 ◽  
pp. 174480692090235
Author(s):  
Bassir Caravan ◽  
Lizbeth Hu ◽  
Daniel Veyg ◽  
Prathamesh Kulkarni ◽  
Qiaosheng Zhang ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Therapeutic Target ◽  
Sleep Spindles

scholarly journals Something Else Going On? Diagnostic Uncertainty in Children with Chronic Pain and Their Parents

Children ◽  
2020 ◽  
Vol 7 (10) ◽  
pp. 165
Author(s):  
Vivek Tanna ◽  
Lauren C. Heathcote ◽  
Marissa S. Heirich ◽  
Gillian Rush ◽  
Alexandra Neville ◽  
...  
Keyword(s):  
United States ◽  
Chronic Pain ◽  
Risk Factor ◽  
Health Problem ◽  
Therapeutic Target ◽  
The United States ◽  
Pain Clinic ◽  
Diagnostic Uncertainty ◽  
Pediatric Chronic Pain ◽  
Lower Pain

Diagnostic uncertainty, the perceived lack of an accurate explanation of the patient’s health problem, remains relatively unstudied in children. This study examined the prevalence, familial concordance, and correlates of diagnostic uncertainty in children and their parents presenting to a multidisciplinary pain clinic in the United States. One hundred and twenty-six parents and 91 of their children (Mage = 13.93 years, range = 8–18 years) completed a brief three-item measure of diagnostic uncertainty, as well as measures of pain-related distress and functioning. Forty-eight percent of children and 37% of parents believed something else was going on with the child’s pain that doctors had not found out about yet. Across the three items, 66%–77% of children and their parents agreed in their endorsement of diagnostic uncertainty. Parents who believed that something else was going on with their child’s pain had children with higher avoidance of pain-related activities (F = 5.601, p = 0.020) and lower pain willingness (F = 4.782, p = 0.032). Neither parent nor child diagnostic uncertainty was significantly related to the child’s pain-related functioning. Diagnostic uncertainty, particularly in parents, is relevant in the experience of pediatric chronic pain and warrants further investigation as both a risk factor and therapeutic target.

scholarly journals Involvement of the hippocampus in chronic pain and depression

2019 ◽  
Vol 5 (4) ◽  
pp. 288-298 ◽  
Author(s):  
Tahmineh Mokhtari ◽  
Yiheng Tu ◽  
Li Hu
Keyword(s):  
Chronic Pain ◽  
Effective Treatment ◽  
Neurotrophic Factors ◽  
Therapeutic Target ◽  
Hippocampal Neurogenesis ◽  
Inflammatory Factors ◽  
Functional Changes ◽  
Proinflammatory Factors

Increases in depressive behaviors have been reported in patients experiencing chronic pain. In these patients, the symptoms of pain and depression commonly coexist, impairing their lives and challenging effective treatment. The hippocampus may play a role in both chronic pain and depression. A reduction in the volume of the hippocampus is related to reduced neurogenesis and neuroplasticity in cases of chronic pain and depression. Moreover, an increase of proinflammatory factors and a reduction of neurotrophic factors have been reported to modulate the hippocampal neurogenesis and neuroplasticity in chronic pain and depression. This review discusses the mechanisms underlying the depressive-like behavior accompanying chronic pain, emphasizing the structural and functional changes in the hippocampus. We also discuss the hypothesis that pro-inflammatory factors and neurotrophic factors expressed in the hippocampus may serve as a therapeutic target for comorbid chronic pain and depression.

The Dorsal Root Ganglion as a Therapeutic Target for Chronic Pain

2016 ◽  
Vol 41 (4) ◽  
pp. 511-519 ◽  
Author(s):  
Liong Liem ◽  
Eric van Dongen ◽  
Frank J. Huygen ◽  
Peter Staats ◽  
Jeff Kramer
Keyword(s):  
Chronic Pain ◽  
Dorsal Root Ganglion ◽  
Therapeutic Target ◽  
Dorsal Root
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