scholarly journals Antinociceptive Effect of Magnolol in a Neuropathic Pain Model of Mouse

2021 ◽  
Vol Volume 14 ◽  
pp. 2083-2093
Author(s):  
Xiao Zhang ◽  
Juntao Wang ◽  
Aihua Sui ◽  
Nannan Zhang ◽  
Qiulan Lv ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Antinociceptive Effect ◽  
Pain Model ◽  
Neuropathic Pain Model

scholarly journals The activation of galanin receptor 2 plays an antinociceptive effect in nucleus accumbens of rats with neuropathic pain

2021 ◽  
Vol 71 (1) ◽  
Author(s):  
Yan Dong ◽  
Chong-Yang Li ◽  
Xiao-Min Zhang ◽  
Ya-Nan Liu ◽  
Shuang Yang ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Nucleus Accumbens ◽  
Pain Threshold ◽  
Antinociceptive Effect ◽  
Galanin Receptor ◽  
Pain Model ◽  
Withdrawal Threshold ◽  
Neuropathic Pain Model ◽  
Galanin Receptors ◽  
Intact Rats

AbstractOur previous research has shown that galanin plays an antinociceptive effect via binding to galanin receptors (GalRs) in nucleus accumbens (NAc). This study focused on the involvement of GalR2 in galanin-induced antinociceptive effect in NAc of neuropathic pain rats. The chronic constriction injury of sciatic nerve (CCI) was used to mimic neuropathic pain model. The hind paw withdrawal latency (HWL) to thermal stimulation and hind paw withdrawal threshold (HWT) to mechanical stimulation were measured as the indicators of pain threshold. The results showed that 14 and 28 days after CCI, the expression of GalR2 was up-regulated in bilateral NAc of rats, and intra-NAc injection of GalR2 antagonist M871 reversed galanin-induced increases in HWL and HWT of CCI rats. Furthermore, intra-NAc injection of GalR2 agonist M1145 induced increases in HWL and HWT at day 14 and day 28 after CCI, which could also be reversed by M871. Finally, we found that M1145-induced antinociceptive effect in NAc of CCI rats was stronger than that in intact rats. These results imply that the GalR2 is activated in the NAc from day 14 to day 28 after CCI and GalR2 is involved in the galanin-induced antinociceptive effect in NAc of CCI rats.

Antinociceptive effect ofButea monospermaon vincristine-induced neuropathic pain model in rats

2012 ◽  
Vol 29 (1) ◽  
pp. 3-13 ◽  
Author(s):  
Venkata Rathina Kumar Thiagarajan ◽  
Palanichamy Shanmugam ◽  
Uma Maheswari Krishnan ◽  
Arunachalam Muthuraman ◽  
Nirmal Singh
Keyword(s):  
Neuropathic Pain ◽  
Antinociceptive Effect ◽  
Pain Model ◽  
Neuropathic Pain Model

Antinociceptive effect of matrine on vincristine-induced neuropathic pain model in mice

2013 ◽  
Vol 35 (6) ◽  
pp. 815-821 ◽  
Author(s):  
Dun Linglu ◽  
Li Yuxiang ◽  
Xu Yaqiong ◽  
Zhou Ru ◽  
Ma Lin ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Antinociceptive Effect ◽  
Pain Model ◽  
Neuropathic Pain Model

scholarly journals The antinociceptive effect of reversible monoamine oxidase-A inhibitors in a mouse neuropathic pain model

2013 ◽  
Vol 44 ◽  
pp. 136-142 ◽  
Author(s):  
Jardel Gomes Villarinho ◽  
Kelly de Vargas Pinheiro ◽  
Francielle de Vargas Pinheiro ◽  
Sara Marchesan Oliveira ◽  
Pablo Machado ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Monoamine Oxidase ◽  
Antinociceptive Effect ◽  
Monoamine Oxidase A ◽  
Pain Model ◽  
Neuropathic Pain Model

Enhancement of antinociceptive effect of morphine by antidepressants in diabetic neuropathic pain model

2014 ◽  
Vol 66 (2) ◽  
pp. 228-234 ◽  
Author(s):  
Krystyna Cegielska-Perun ◽  
Magdalena Bujalska-Zadrożny ◽  
Emilia Gąsińska ◽  
Helena Elżbieta Makulska-Nowak
Keyword(s):  
Neuropathic Pain ◽  
Antinociceptive Effect ◽  
Diabetic Neuropathic Pain ◽  
Pain Model ◽  
Neuropathic Pain Model

scholarly journals Evaluation of Lercanidipine in Paclitaxel-Induced Neuropathic Pain Model in Rat: A Preliminary Study

2012 ◽  
Vol 2012 ◽  
pp. 1-5
Author(s):  
Lekha Saha ◽  
Debasish Hota ◽  
Amitava Chakrabarti
Keyword(s):  
Neuropathic Pain ◽  
Pain Threshold ◽  
Antinociceptive Effect ◽  
Tail Flick ◽  
Cold Allodynia ◽  
Pain Model ◽  
Neuropathic Pain Model ◽  
Preliminary Study

Objective. To demonstrate the antinociceptive effect of lercanidipine in paclitaxel-induced neuropathy model in rat. Materials and Methods. A total of 30 rats were divided into five groups of six rats in each group as follows: Gr I: 0.9% NaCl, Gr II: paclitaxel + 0.9% NaCl, Gr III: paclitaxel + lercanidipine 0.5 μg/kg, Gr IV: paclitaxel + lercanidipine 1 μg/kg, and Gr V: paclitaxel + lercanidipine 2.5 μg/kg. Paclitaxel-induced neuropathic pain in rat was produced by single intraperitoneal (i.p.) injection of 1 mg/kg of paclitaxel on four alternate days (0, 2, 4, and 6). The tail flick and cold allodynia methods were used for assessing the pain threshold, and the assessments were done on days 0 (before first dose of paclitaxel) and on days 7, 14, 21, and 28. Results. There was a significant decrease (P<0.001) in the tail flick and cold allodynia latency in the paclitaxel-alone group from day 14 onward when compared with day 0. In the lercanidipine groups, the decrease in the tail flick and cold allodynia latency was not observed in 1.0 and 2.5 μg/kg groups and it was statistically significant (P<0.01) when compared with paclitaxel-alone group.

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