scholarly journals Effectiveness of Pregabalin Treatment for Neuropathic Pain in Patients with Spine Diseases: A Pooled Analysis of Two Multicenter Observational Studies in Japan

2021 ◽  
Vol Volume 14 ◽  
pp. 757-771
Author(s):  
Toshihiko Taguchi ◽  
Shogo Nakano ◽  
Kazutaka Nozawa
Keyword(s):  
Neuropathic Pain ◽  
Observational Studies ◽  
Pooled Analysis ◽  
Spine Diseases

scholarly journals Relationships between intensity, duration, cumulative dose, and timing of smoking with age at menopause: A pooled analysis of individual data from 17 observational studies

PLoS Medicine ◽  
2018 ◽  
Vol 15 (11) ◽  
pp. e1002704 ◽  
Author(s):  
Dongshan Zhu ◽  
Hsin-Fang Chung ◽  
Nirmala Pandeya ◽  
Annette J. Dobson ◽  
Janet E. Cade ◽  
...  
Keyword(s):  
Cumulative Dose ◽  
Observational Studies ◽  
Pooled Analysis ◽  
Individual Data ◽  
Age At Menopause

Risk of Gastrointestinal Bleeding on Treatment With Statin Alone or With Concomitant Administration of Warfarin: A Systematic Review and Meta-analysis of 5.3 Million Participants

2021 ◽  
pp. 106002802110497
Author(s):  
Akshaya Srikanth Bhagavathula ◽  
Kota Vidyasaga ◽  
Eyob Alemayehu Gebreyohannes ◽  
Wubshet Tesfaye
Keyword(s):  
Gastrointestinal Bleeding ◽  
Observational Studies ◽  
Data Extraction ◽  
Meta Analysis ◽  
Concomitant Administration ◽  
Pooled Analysis ◽  
Data Synthesis ◽  
Study Selection ◽  
Statin Monotherapy ◽  
Statin Use

Objective: This study aimed to comprehensively evaluate the risk of gastrointestinal bleeding (GIB) with statin monotherapy or with concomitant warfarin use. Data Sources: PubMed, Web of Science, and EMBASE (via Scopus) were searched for observational studies that reported the risk of GIB in adults on statin therapy or with concomitant warfarin use until August 28, 2021. Study Selection and Data Extraction: Observational studies evaluating the risk of GIB in adults (age >18 years) on statin medication or concomitant use with warfarin were included. Data Synthesis: In all, 14 studies with a total of 5 235 123 participants, reporting 48 677 GIB events (43 734 from statin users and 4943 from users of statin combined with warfarin), were included in the analyses. The pooled analysis revealed no difference in the risk of GIB with statin monotherapy (relative risk [RR]: 0.65; 95% CI: 0.42-1.02) or concomitant statin + warfarin use (RR: 0.97; 95% CI: 0.91-1.02). Prior use of statin was not associated with GIB risk (RR: 0.88; 95% CI: 0.63-1.22), whereas a shorter duration of statin use (<5 years) was associated with a lower risk of GIB (RR: 0.42; 95% CI: 0.18-0.97). Relevance to Patient Care and Clinical Practice: This analysis provides strong evidence on the association between statin use (with/without warfarin) and risk of GIB. Conclusion: Statin alone or combined with warfarin was not significantly associated with either an increased or decreased risk of GIB. The GIB risk was significantly lower when statins were used for a short duration (<5 years). The putative relationship between statins and GIB in warfarin users warrant further investigation.

Abstract P135: Covid-19 And Hypertension: Pooled Analysis Of Observational Studies

Hypertension ◽  
2020 ◽  
Vol 76 (Suppl_1) ◽  
Author(s):  
Vikramaditya Reddy Samala Venkata ◽  
Rahul Gupta ◽  
Surya Kiran Aedma
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Severe Acute Respiratory Syndrome ◽  
Clinical Outcomes ◽  
Random Effects ◽  
Observational Studies ◽  
Retrospective Studies ◽  
Pooled Analysis ◽  
Random Effects Model ◽  
Electronic Search

Introduction: The pandemic of COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 infection. Although clinical data is limited, studies published so far raise concerns about an association between hypertension and worse clinical outcomes in COVID-19. Our aim was to assess the association between hypertension and mortality in COVID-19 patients. Methods: A systematic electronic search was performed in PubMed, Embase, and Google Scholar. Retrospective studies with original COVID-19 hospitalized patient data and reporting prevalence of hypertension was included in our study. Pooled analysis using a random-effects model was performed to look at the association between hypertension and mortality. Results: 22 studies from 8 countries with over 11,000 patients were included in our analysis. Hypertension was the most prevalent comorbidity in hospitalized COVID-19 patients (42%), followed by diabetes mellitus (23%)(Figure 1). Hypertension by itself was associated with higher rates of mortality (Figure 2). Other less prevalent comorbidities include non-hypertensive cardiovascular disease (11%), CKD (6%), CVA (5%), COPD (4.3%). Conclusion: Hypertension is the most prevalent comorbidity in hospitalized COVID-19 patients, followed by diabetes mellitus and was found to be significantly associated with higher rates of mortality. Surprisingly, hypertension is significantly more common than COPD in this population. The reason for this is unclear, there is no evidence currently that hypertension is directly related to mortality in this population. More randomized studies are needed to assess the effect of hypertension on mortality in COVID-19 patients.

Treatment of hepatitis C after kidney transplant: A pooled analysis of observational studies

2014 ◽  
Vol 86 (6) ◽  
pp. 933-940 ◽  
Author(s):  
Fabrizio Fabrizi ◽  
Alessandra Penatti ◽  
Piergiorgio Messa ◽  
Paul Martin
Keyword(s):  
Hepatitis C ◽  
Kidney Transplant ◽  
Observational Studies ◽  
Pooled Analysis

scholarly journals Use of moist oral snuff (snus) and pancreatic cancer: Pooled analysis of nine prospective observational studies

2017 ◽  
Vol 141 (4) ◽  
pp. 687-693 ◽  
Author(s):  
Marzieh Araghi ◽  
Maria Rosaria Galanti ◽  
Michael Lundberg ◽  
Anton Lager ◽  
Gunnar Engström ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Observational Studies ◽  
Pooled Analysis

scholarly journals Breast-Feeding and Childhood-Onset Type 1 Diabetes: A pooled analysis of individual participant data from 43 observational studies

Diabetes Care ◽  
2012 ◽  
Vol 35 (11) ◽  
pp. 2215-2225 ◽  
Author(s):  
C. R. Cardwell ◽  
L. C. Stene ◽  
J. Ludvigsson ◽  
J. Rosenbauer ◽  
O. Cinek ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Breast Feeding ◽  
Observational Studies ◽  
Pooled Analysis ◽  
Individual Participant Data ◽  
Childhood Onset ◽  
Onset Type ◽  
Individual Participant

Survival outcomes in iron chelated and non-chelated patients with lower-risk myelodysplastic syndromes: Review and pooled analysis of observational studies

2017 ◽  
Vol 57 ◽  
pp. 104-108 ◽  
Author(s):  
Ivo Abraham ◽  
Majed Al Yami ◽  
Seongseok Yun ◽  
Hee-Ju Kim ◽  
Nicole D. Vincelette ◽  
...  
Keyword(s):  
Myelodysplastic Syndromes ◽  
Lower Risk ◽  
Observational Studies ◽  
Pooled Analysis ◽  
Survival Outcomes

Effects of Pregabalin in Patients with Neuropathic Pain Previously Treated with Gabapentin: A Pooled Analysis of Parallel-Group, Randomized, Placebo-controlled Clinical Trials

Pain Practice ◽  
2016 ◽  
Vol 17 (6) ◽  
pp. 718-728 ◽  
Author(s):  
John D. Markman ◽  
Troels Staehelin Jensen ◽  
David Semel ◽  
Chunming Li ◽  
Bruce Parsons ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Neuropathic Pain ◽  
Pooled Analysis ◽  
Controlled Clinical Trials ◽  
Parallel Group ◽  
Previously Treated
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