Effects of Pregabalin in Patients with Neuropathic Pain Previously Treated with Gabapentin: A Pooled Analysis of Parallel-Group, Randomized, Placebo-controlled Clinical Trials

Pain Practice ◽  
2016 ◽  
Vol 17 (6) ◽  
pp. 718-728 ◽  
Author(s):  
John D. Markman ◽  
Troels Staehelin Jensen ◽  
David Semel ◽  
Chunming Li ◽  
Bruce Parsons ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Neuropathic Pain ◽  
Pooled Analysis ◽  
Controlled Clinical Trials ◽  
Parallel Group ◽  
Previously Treated

(286) Efficacy of duloxetine in patients with fibromyalgia: Pooled analysis of four placebo-controlled clinical trials

2008 ◽  
Vol 9 (4) ◽  
pp. 47 ◽  
Author(s):  
L. Arnold ◽  
D. Clauw ◽  
M. Wohlreich ◽  
F. Wang ◽  
J. Ahl ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Pooled Analysis ◽  
Controlled Clinical Trials

Independence Estimating Equations for Controlled Clinical Trials with Small Sample Sizes

2006 ◽  
Vol 45 (04) ◽  
pp. 430-434 ◽  
Author(s):  
G. Dahmen ◽  
A. Ziegler
Keyword(s):  
Clinical Trials ◽  
Estimating Equations ◽  
Small Sample ◽  
Repeated Measurements ◽  
Robust Estimator ◽  
Variance Estimator ◽  
Sample Sizes ◽  
Controlled Clinical Trials ◽  
Parallel Group ◽  
Small Sample Sizes

Summary Objectives: The application of independence estimating equations (IEE) for controlled clinical trials (CCTs) has recently been discussed, and recommendations for its use have been derived for testing hypotheses. The robust estimator of variance has been shown to be liberal for small sample sizes. Therefore a series of modifications has been proposed. In this paper we systematically compare confidence intervals (CIs) proposed in the literature for situations that are common in CCTs. Methods: Using Monte-Carlo simulation studies, we compared the coverage probabilities of CIs and non-convergence probabilities for the parameters of the mean structure for small samples using modifications of the variance estimator proposed by Mancl and de Rouen [7], Morel et al. [8] and Pan [3]. Results: None of the proposed modifications behave well in each investigated situation. For parallel group designs with repeated measurements and binary response the method proposed by Pan maintains the nominal level. We observed non-convergence of the IEE algorithm in up to 10% of the replicates depending on response probabilities in the treatment groups. For comparing slopes with continuous responses, the approach of Morel et al. can be recommended. Conclusions: Results of non-convergence probabilities show that IEE should not be used in parallel group designs with binary endpoints and response probabilities close to 0 or 1. Modifications of the robust variance estimator should be used for sample sizes up to 100 clusters for CI estimation.

All-cause Mortality in Placebo-controlled Clinical Trials of Methylnaltrexone: A Pooled Analysis

2013 ◽  
Vol 108 ◽  
pp. S570-S571
Author(s):  
Lynn Webster ◽  
Darren Brenner ◽  
Robert Rolleri ◽  
Andrew Barrett ◽  
Enoch Bortey ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Pooled Analysis ◽  
Controlled Clinical Trials ◽  
All Cause Mortality
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