scholarly journals Could Mesna and Celery Seed Cotherapy Modulate Oxidative Stress and Inflammation of the Urinary Bladder Induced by Ifosfamide in Rabbits?

2021 ◽  
Vol Volume 14 ◽  
pp. 5837-5847
Author(s):  
Ayman M Mousa ◽  
Khaled S Allemailem ◽  
Fahad A Alhumaydhi ◽  
Faris Alrumaihi ◽  
Ahmad Almatroudi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Urinary Bladder ◽  
Celery Seed

Potential Protective Effect of Dl-3-n-Butylphthalide on Chronic Cerebral Ischemia Brain Injury

2021 ◽  
Vol 21 ◽  
Author(s):  
Fangfang Zhao ◽  
Yumin Luo
Keyword(s):  
Oxidative Stress ◽  
Cerebral Ischemia ◽  
Brain Dysfunction ◽  
Cerebrovascular Diseases ◽  
Pathophysiological Mechanism ◽  
Chronic Cerebral Ischemia ◽  
Celery Seed ◽  
Prevention And Treatment ◽  
Ischemic Cerebrovascular Diseases ◽  
The Common

: Chronic cerebral ischemia is one of the common ischemic cerebrovascular diseases. Chronic cerebral ischemia can lead to brain dysfunction, and its pathophysiological mechanism involves inflammation, blood-brain barrier destruction, oxidative stress, and other factors. Due to it being difficult to detect, it is easily overlooked, and it is often only observed following onset of cognitive dysfunction. At present, there are few drugs for this treatment. DL-3-N-BUTYLPHTHALIDE (NBP), a compound extracted from celery seed, may play an important role in protecting against brain damage caused by chronic cerebral ischemia. Therefore, we pay more attention to the prevention and treatment of NBP on chronic cerebral ischemia.

scholarly journals Phloroglucinol Protects the Urinary Bladder Via Inhibition of Oxidative Stress and Inflammation in a Rat Model of Cyclophosphamide-induced Interstitial Cystitis

2015 ◽  
Vol 128 (7) ◽  
pp. 956-962 ◽  
Author(s):  
Ya-Qiang He ◽  
Wei-Tao Zhang ◽  
Chang-Hua Shi ◽  
Fang-Ming Wang ◽  
Xiao-Jun Tian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Urinary Bladder ◽  
Interstitial Cystitis ◽  
Rat Model

scholarly journals P2X7 Receptor Blockade Protects Against Acrolein-Induced Bladder Damage: A Potential New Therapeutic Approach for the Treatment of Bladder Inflammatory Diseases

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhinoos Taidi ◽  
Tommy Zhou ◽  
Kate H. Moore ◽  
Kylie J. Mansfield ◽  
Lu Liu
Keyword(s):  
Oxidative Stress ◽  
Urinary Bladder ◽  
Receptor Antagonist ◽  
P2x7 Receptor ◽  
Ex Vivo ◽  
Therapeutic Option ◽  
Bladder Wall ◽  
Loss Of Function ◽  
Inflammatory Conditions

Inflammatory conditions of the urinary bladder have been shown to be associated with urothelial damage and loss of function. The purinergic P2X7 receptor has been implicated in several inflammatory conditions. The aim of this study was to investigate the role of the P2X7 receptor in acrolein-induced inflammatory damage using the porcine urinary bladder. For this purpose, an ex-vivo model of porcine urothelial damage induced by direct instillation of acrolein into the whole bladder lumen was used. To determine the role of the P2X7 receptor, the bladders were pre-incubated with a selective P2X7 receptor antagonist, A804598 (10 μM), for 1 h. The effects of the acrolein-induced urothelial damage on the bladder’s function were assessed by examining the bladder wall contractile response, structure changes, apoptosis, and oxidative stress in the bladder tissues. The acrolein treatment led to significant damage to the urothelium histology, tight junction expression, and contractile responses. Acrolein also induced apoptosis in the mucosa layer. All these acrolein-induced responses were attenuated by pre-treatment with the P2X7 receptor antagonist A804598. Acrolein also significantly induced DNA oxidation in the submucosal layer; however, the P2X7 receptor antagonism did not show any protective effect towards the acrolein-induced oxidative stress. These findings suggested that the P2X7 receptor is involved in the acrolein-induced damage to the urothelium; therefore, the P2X7 receptor antagonists may be a new therapeutic option for the treatment of bladder inflammation.

The Protective Effects of Vitamin E on Urinary Bladder Apoptosis and Oxidative Stress in Streptozotocin-induced Diabetic Rats

Urology ◽  
2010 ◽  
Vol 75 (4) ◽  
pp. 902-906 ◽  
Author(s):  
Mehmet C. Ustuner ◽  
Sahin Kabay ◽  
Hilmi Ozden ◽  
Gul Guven ◽  
Mehmet Yucel ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Urinary Bladder ◽  
Diabetic Rats ◽  
Protective Effects ◽  
And Oxidative Stress

Aging impairs neurogenic contraction in guinea pig urinary bladder: role of oxidative stress and melatonin

2007 ◽  
Vol 293 (2) ◽  
pp. R793-R803 ◽  
Author(s):  
Pedro J. Gómez-Pinilla ◽  
Maria J. Pozo ◽  
Pedro J. Camello
Keyword(s):  
Oxidative Stress ◽  
Urinary Bladder ◽  
Guinea Pig ◽  
Electrical Field Stimulation ◽  
Neuromuscular Function ◽  
Melatonin Treatment ◽  
Age Related ◽  
Afferent Fibers ◽  
Bladder Disorders ◽  
The Impact

The incidence of urinary bladder disturbances increases with age, and free radical accumulation has been proposed as a causal factor. Here we investigated the association between changes in bladder neuromuscular function and oxidative stress in aging and the possible benefits of melatonin treatment. Neuromuscular function was assessed by electrical field stimulation (EFS) of isolated guinea pig detrusor strips from adult and aged female guinea pigs. A group of adult and aged animals were treated with 2.5 mg·kg−1·day−1 melatonin for 28 days. Neurotransmitter blockers were used to dissect pharmacologically the EFS-elicited contractile response. EFS induced a neurogenic and frequency-dependent contraction that was impaired by aging. This impairment is in part related to a decrease in detrusor myogenic contractility. Age also decreased the sensitivity of the contraction to pharmacological blockade of purinergic and sensitive fibers but increased the effect of blockade of nitrergic and adrenergic nerves. The density of cholinergic and nitrergic nerves remained unaltered, but aging modified afferent fibers. These changes were associated with an increased level of markers for oxidative stress. Melatonin treatment normalized oxidative levels and counteracted the aging-associated changes in bladder neuromuscular function. In conclusion, these results show that aging modifies neurogenic contraction and the functional profile of the urinary bladder plexus and simultaneously increases the oxidative damage to the organ. Melatonin reduces oxidative stress and improves the age-induced changes in bladder neuromuscular function, which could be of importance in reducing the impact of age-related bladder disorders.

Increased oxidative stress with gene alteration in urinary bladder urothelium after the Chernobyl accident

2000 ◽  
Vol 86 (6) ◽  
pp. 790-798 ◽  
Author(s):  
Alina Romanenko ◽  
Keiichirou Morimura ◽  
Hideki Wanibuchi ◽  
Elsayed I. Salim ◽  
Anna Kinoshita ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Urinary Bladder ◽  
Chernobyl Accident ◽  
Bladder Urothelium ◽  
Gene Alteration

scholarly journals Elevated oxidative stress and DNA damage and repair levels in urinary bladder carcinomas associated with schistosomiasis

2008 ◽  
Vol 123 (3) ◽  
pp. 601-608 ◽  
Author(s):  
Elsayed I. Salim ◽  
Keiichirou Morimura ◽  
Ahmed Menesi ◽  
Mohammed El-Lity ◽  
Shoji Fukushima ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Urinary Bladder ◽  
Dna Damage And Repair ◽  
Bladder Carcinomas

Role of oxidative stress and mitochondria in onset of urinary bladder dysfunction under acute urine retention

2013 ◽  
Vol 78 (5) ◽  
pp. 542-548 ◽  
Author(s):  
V. I. Kirpatovsky ◽  
E. Y. Plotnikov ◽  
I. S. Mudraya ◽  
S. A. Golovanov ◽  
V. V. Drozhzheva ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Urinary Bladder ◽  
Bladder Dysfunction ◽  
Urine Retention ◽  
Urinary Bladder Dysfunction ◽  
Acute Urine Retention
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