scholarly journals Elevated oxidative stress and DNA damage and repair levels in urinary bladder carcinomas associated with schistosomiasis

2008 ◽  
Vol 123 (3) ◽  
pp. 601-608 ◽  
Author(s):  
Elsayed I. Salim ◽  
Keiichirou Morimura ◽  
Ahmed Menesi ◽  
Mohammed El-Lity ◽  
Shoji Fukushima ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Urinary Bladder ◽  
Dna Damage And Repair ◽  
Bladder Carcinomas

scholarly journals Effects of ambient PM2.5and 9-nitroanthracene on DNA damage and repair, oxidative stress and metabolic enzymes in the lungs of rats

2017 ◽  
Vol 6 (5) ◽  
pp. 654-663 ◽  
Author(s):  
Ruijin Li ◽  
Lifang Zhao ◽  
Li Zhang ◽  
Minghui Chen ◽  
Jing Shi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lung Cancer ◽  
Dna Damage ◽  
Particulate Matter ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Fine Particulate Matter ◽  
Complex Mixture ◽  
Dna Damage And Repair ◽  
Fine Particulate

Ambient fine particulate matter (PM2.5) is a complex mixture associated with lung cancer risk.

scholarly journals We Are Ageing

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Genovefa D. Kolovou ◽  
Vana Kolovou ◽  
Sophie Mavrogeni
Keyword(s):  
Oxidative Stress ◽  
Growth Hormone ◽  
Dna Damage ◽  
Growth Factor ◽  
Glucose Metabolism ◽  
Caloric Restriction ◽  
Environmental Exposure ◽  
Target Of Rapamycin ◽  
Insulin Like Growth Factor ◽  
Dna Damage And Repair

Ageing and longevity is unquestioningly complex. Several thoughts and mechanisms of ageing such as pathways involved in oxidative stress, lipid and glucose metabolism, inflammation, DNA damage and repair, growth hormone axis and insulin-like growth factor (GH/IGF), and environmental exposure have been proposed. Also, some theories of ageing were introduced. To date, the most promising leads for longevity are caloric restriction, particularly target of rapamycin (TOR), sirtuins, hexarelin and hormetic responses. This review is an attempt to analyze the mechanisms and theories of ageing and achieving longevity.

scholarly journals IKKα modulates oxidative stress-induced DNA damage and repair in primary human OA chondrocytes

2012 ◽  
Vol 20 ◽  
pp. S144
Author(s):  
S. Neri ◽  
S. Guidotti ◽  
D. Platano ◽  
E. Olivotto ◽  
A. Facchini ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Dna Damage And Repair ◽  
Oa Chondrocytes

scholarly journals Cross-Talk between Amyloid, Tau Protein and Free Radicals in Post-Ischemic Brain Neurodegeneration in the Form of Alzheimer’s Disease Proteinopathy

Antioxidants ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 146
Author(s):  
Ryszard Pluta ◽  
Jacek Kiś ◽  
Sławomir Januszewski ◽  
Mirosław Jabłoński ◽  
Stanisław J. Czuczwar
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Dna Damage ◽  
Free Radicals ◽  
Brain Ischemia ◽  
Tau Protein ◽  
Dna Damage And Repair ◽  
Ischemic Brain ◽  
Remarkable Progress

Recent years have seen remarkable progress in research into free radicals oxidative stress, particularly in the context of post-ischemic recirculation brain injury. Oxidative stress in post-ischemic tissues violates the integrity of the genome, causing DNA damage, death of neuronal, glial and vascular cells, and impaired neurological outcome after brain ischemia. Indeed, it is now known that DNA damage and repair play a key role in post-stroke white and gray matter remodeling, and restoring the integrity of the blood-brain barrier. This review will present one of the newly characterized mechanisms that emerged with genomic and proteomic development that led to brain ischemia to a new level of post-ischemic neuropathological mechanisms, such as the presence of amyloid plaques and the development of neurofibrillary tangles, which further exacerbate oxidative stress. Finally, we hypothesize that modified amyloid and the tau protein, along with the oxidative stress generated, are new key elements in the vicious circle important in the development of post-ischemic neurodegeneration in a type of Alzheimer’s disease proteinopathy.

scholarly journals Symmetrical dimethylation of H4R3: A bridge linking DNA damage and repair upon oxidative stress

Redox Biology ◽  
2020 ◽  
Vol 37 ◽  
pp. 101653 ◽  
Author(s):  
Zhuang Ma ◽  
Wentao Wang ◽  
Shiwei Wang ◽  
Xingqi Zhao ◽  
Ying Ma ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Dna Damage And Repair
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