scholarly journals Determinants of Premature Rupture of Membranes Among Pregnant Women Admitted to Public Hospitals in Southern Ethiopia, 2020: A Hospital-Based Case–Control Study

2021 ◽  
Vol Volume 13 ◽  
pp. 613-626
Author(s):  
Aklilu Habte ◽  
Samuel Dessu ◽  
Kaleegziabher Lukas
Keyword(s):  
Pregnant Women ◽  
Case Control Study ◽  
Case Control ◽  
Public Hospitals ◽  
Southern Ethiopia ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Control Study

scholarly journals Interleukin-18 gene polymorphism in pregnancy With premature rupture of membranes: A case-control study

2021 ◽  
Vol 28 (2) ◽  
pp. 144-156
Author(s):  
I. O. Bushtyreva ◽  
N. B. Kuznetsova ◽  
M. P. Dmitrieva ◽  
E. V. Mashkina ◽  
O. S. Oksenyuk ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Case Control Study ◽  
Gene Promoter ◽  
Case Control ◽  
Multiple Gestation ◽  
Interleukin 18 ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Extremely Preterm ◽  
Control Study

Background. Imbalanced pro- and anti-inflammatory systems can unfavourably condition carrying of pregnancy and provoke gestation complications, such as premature rupture of membranes.Objectives. Assessing the contribution of SNP variants -137G>C (rs187238), -607G>T (rs1946518) and -656A>C (rs5744228) of the IL-18 gene promoter to the incidence of extremely preterm premature rupture of membranes.Methods. A case-control study enrolled 120 pregnant women managed at the Perinatal Centre. The women were divided in two cohorts. The study cohort comprised 80 women with premature rupture of membranes at 22–27 weeks 6 days’ gestation hospitalised in a high-risk pregnancy unit, a control cohort consisted of 40 women with physiological pregnancy at 22–27 weeks 6 days’ gestation following outpatient counselling. The cohorts had comparable obstetric and gynaecological histories. The study exclusion criteria were: multiple gestation, foetal chromosomal anomalies, congenital foetal malformations, pregnancy due to assisted reproduction. Genotyping was performed at positions -137G>C, -607G>T and -656A>C of the IL-18 gene promoter with determining a peripheral blood IL-18 level in cohorts.Results. The premature rupture of membranes cohort had a statistically higher serum interleukin-18 concentration compared to control (p = 0.001). Genotyping of the IL-18 gene promoter revealed a statistically higher rate of homozygous -137G>C mutation (CC genotype) in the premature rupture of membranes cohort at 22–27 weeks 6 days’ term (p <0.001), 67 vs. 27% in control.Conclusion. A homozygous IL-18 -137G>C polymorphic variant associated with elevated blood IL-18 levels is statistically more common in pregnant women having premature rupture of membranes at 22–27 weeks 6 days’ gestation.

scholarly journals Correction to: Risk factors of premature rupture of membranes in public hospitals at Mekele city, Tigray, a case control study

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Natnael Etsay Assefa ◽  
Hailemariam Berhe ◽  
Fiseha Girma ◽  
Kidanemariam Berhe ◽  
Yodit Zewdie Berhe ◽  
...  
Keyword(s):  
Risk Factors ◽  
Case Control Study ◽  
Case Control ◽  
Public Hospitals ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Control Study

scholarly journals Correction to: Risk factors of premature rupture of membranes in public hospitals at Mekele city, Tigray, a case control study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Natnael Etsay Assefa ◽  
Hailemariam Berhe ◽  
Fiseha Girma ◽  
Kidanemaryam Berhe ◽  
Yodit Zewdie Berhe ◽  
...  
Keyword(s):  
Risk Factors ◽  
Case Control Study ◽  
Case Control ◽  
Public Hospitals ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Control Study

scholarly journals Risk factors of premature rupture of membranes in public hospitals at Mekele city, Tigray, a case control study

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Natnael Etsay Assefa ◽  
Hailemariam Berhe ◽  
Fiseha Girma ◽  
Kidanemariam Berhe ◽  
Yodit Zewdie Berhe ◽  
...  
Keyword(s):  
Risk Factors ◽  
Case Control Study ◽  
Case Control ◽  
Public Hospitals ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Control Study

Risk factors for previable premature rupture of membranes or advanced cervical dilation: A case control study

2006 ◽  
Vol 194 (4) ◽  
pp. 1168-1174 ◽  
Author(s):  
Sarah J. Kilpatrick ◽  
Rajita Patil ◽  
Jeness Connell ◽  
Jessica Nichols ◽  
Laura Studee
Keyword(s):  
Risk Factors ◽  
Case Control Study ◽  
Case Control ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Cervical Dilation ◽  
Control Study

scholarly journals Factors associated with preterm birth in Southern Ethiopia: Case-Control Study

2020 ◽  
Author(s):  
Negeso Gebeyehu Gejo ◽  
Melaku Tesfaye W/mariam ◽  
Biruk Assefa Kebede ◽  
Ritbano Ahmed Abdo ◽  
Abebe Alemu Anshebo ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Case Control Study ◽  
Southern Ethiopia ◽  
Preterm Neonates ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Factors Associated ◽  
Induced Hypertension ◽  
Control Study

Abstract Background Preterm birth is defined as one born alive before 37 weeks of pregnancy is completed. Worldwide, prematurity is the second foremost cause of death in children under the age of 5 years. Preterm birth also gives rise to short and long term complications. Therefore, the primary aim of this study was to identify the factors associated with preterm birth in Wachemo University Nigest Eleni Mohammed Memorial referral hospital, Hadiya Zone, Southern Ethiopia. Methods An institution-based unmatched case-control study was conducted from July 01, 2018 to June 30, 2019, among mothers who gave birth in Wachemo University Nigest Eleni Mohammed Memorial referral hospital. Simple random sampling technique was employed to approach study participants. SPSS version 20 software was used for data entry and computing statistical analysis. Both bivariable and multivariable logistic regression analyses were used to determine the association of each independent variable with the dependent variable. Odds ratio with their 95% confidence intervals was computed to identify the presence and strength of association, and statistical significance was affirmed if p < 0.05. Result The current study evaluated 213 medical records of mothers with index neonates (71 cases and 142 controls). Urban residency [AOR = 0.48; 95% Cl; 0.239, 0.962], ANC follow up [AOR = 0.08; 95 Cl; 0.008, 0.694], premature rupture of membranes [AOR = 3.78; 95% Cl; 1.467, 9.749], pregnancy induced hypertension [AOR = 3.77; 95% Cl; 1.408, 10.147], multiple pregnancies [AOR = 5.53; 95% Cl; 2.467, 12.412] were the factors associated with preterm birth. In the present study, more than one-third (36.6%) of preterm neonates have died. Conclusions The present study found that urban residency, ANC follow up, premature rupture of membranes, pregnancy induced hypertension and multiple pregnancies were factors associated with preterm birth. The mortality among preterm neonates is high. Enhancing ANC follow up and early detection and treatment of disorders among pregnant women during ANC and undertaking every effort to improve outcomes of preterm birth and reduce neonatal mortality associated with prematurity is decisive.

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