scholarly journals Physical characterization and in vivo pharmacokinetic study of self-assembling amphotericin B-loaded lecithin-based mixed polymeric micelles

2015 ◽  
pp. 7265 ◽  
Author(s):  
Ming-Thau Sheu ◽  
Ying-Chen Chen ◽  
Chia-Yu Su ◽  
Hua-Jun Jhan ◽  
Hsio-O Ho
Keyword(s):  
Amphotericin B ◽  
Pharmacokinetic Study ◽  
Polymeric Micelles ◽  
Physical Characterization ◽  
Self Assembling ◽  
Mixed Polymeric Micelles

Enhanced oral bioavailability of capsaicin in mixed polymeric micelles: Preparation, in vitro and in vivo evaluation

2014 ◽  
Vol 8 ◽  
pp. 358-366 ◽  
Author(s):  
Yuan Zhu ◽  
Wei Peng ◽  
Jiajia Zhang ◽  
Miaomiao Wang ◽  
Caleb Kesse Firempong ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
Polymeric Micelles ◽  
In Vivo Evaluation ◽  
Mixed Polymeric Micelles

scholarly journals Honokiol/Magnolol-Loaded Self-Assembling Lecithin-Based Mixed Polymeric Micelles (lbMPMs) for Improving Solubility to Enhance Oral Bioavailability

2021 ◽  
Vol Volume 16 ◽  
pp. 651-665
Author(s):  
Hong-Liang Lin ◽  
Wen-Ting Cheng ◽  
Ling-Chun Chen ◽  
Hsiu-O Ho ◽  
Shyr-Yi Lin ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
Polymeric Micelles ◽  
Self Assembling ◽  
Mixed Polymeric Micelles

In-vivo anti-diabetic and wound healing potential of chitosan/alginate/maltodextrin/pluronic-based mixed polymeric micelles: Curcumin therapeutic potential

2018 ◽  
Vol 120 ◽  
pp. 2418-2430 ◽  
Author(s):  
Muhammad Usman Akbar ◽  
Khalid Mahmood Zia ◽  
Muhammad Sajid Hamid Akash ◽  
Ahsan Nazir ◽  
Mohammad Zuber ◽  
...  
Keyword(s):  
Wound Healing ◽  
Polymeric Micelles ◽  
Therapeutic Potential ◽  
Mixed Polymeric Micelles

scholarly journals Development and Characterization of Lecithin-based Self-assembling Mixed Polymeric Micellar (saMPMs) Drug Delivery Systems for Curcumin

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Ling-Chun Chen ◽  
Yin-Chen Chen ◽  
Chia-Yu Su ◽  
Wan-Ping Wong ◽  
Ming-Thau Sheu ◽  
...  
Keyword(s):  
Particle Size ◽  
Polymeric Micelles ◽  
Drug Loading ◽  
Physical Stability ◽  
Sodium Deoxycholate ◽  
Hydrophobic Core ◽  
Self Assembling ◽  
Human Disorders

Abstract Self-assembling mixed polymeric micelles (saMPMs) were developed for overcoming major obstacles of poor bioavailability (BA) associated with curcumin delivery. Lecithin added was functioned to enlarge the hydrophobic core of MPMs providing greater solubilization capacity. Amphiphilic polymers (sodium deoxycholate [NaDOC], TPGS, CREMOPHOR, or a PLURONIC series) were examined for potentially self-assembling to form MPMs (saMPMs) with the addition of lecithin. Particle size, size distribution, encapsulation efficacy (E.E.), and drug loading (D.L.) of the mixed micelles were optimally studied for their influences on the physical stability and release of encapsulated drugs. Overall, curcumin:lecithin:NaDOC and curcumin:lecithin:PLURONIC P123 in ratios of 2:1:5 and 5:2:20, respectively, were optimally obtained with a particle size of < 200 nm, an E.E. of >80%, and a D.L. of >10%. The formulated system efficiently stabilized curcumin in phosphate-buffered saline (PBS) at room temperature or 4 °C and in fetal bovine serum or PBS at 37 °C and delayed the in vitro curcumin release. In vivo results further demonstrated that the slow release of curcumin from micelles and prolonged duration increased the curcumin BA followed oral and intravenous administrations in rats. Thus, lecithin-based saMPMs represent an effective curcumin delivery system, and enhancing BA of curcumin can enable its wide applications for treating human disorders.

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