scholarly journals Development and characterization of self-assembling lecithin-based mixed polymeric micelles containing quercetin in cancer treatment and an in vivo pharmacokinetic study

2016 ◽  
pp. 1557 ◽  
Author(s):  
Ming-Thau Sheu ◽  
Ling-Chun Chen ◽  
Ying-Chen Chen ◽  
Chia-Yu Su ◽  
Chung-Shu Hong ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Pharmacokinetic Study ◽  
Polymeric Micelles ◽  
Self Assembling ◽  
Mixed Polymeric Micelles

Molecular characterization of α,β-poly(N-2-hydroxyethyl)-dl-aspartamide derivatives as potential self-assembling copolymers forming polymeric micelles

Polymer ◽  
2003 ◽  
Vol 44 (17) ◽  
pp. 4871-4879 ◽  
Author(s):  
R. Mendichi ◽  
A. Giacometti Schieroni ◽  
G. Cavallaro ◽  
M. Licciardi ◽  
G. Giammona
Keyword(s):  
Molecular Characterization ◽  
Polymeric Micelles ◽  
Self Assembling

Enhanced oral bioavailability of capsaicin in mixed polymeric micelles: Preparation, in vitro and in vivo evaluation

2014 ◽  
Vol 8 ◽  
pp. 358-366 ◽  
Author(s):  
Yuan Zhu ◽  
Wei Peng ◽  
Jiajia Zhang ◽  
Miaomiao Wang ◽  
Caleb Kesse Firempong ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
Polymeric Micelles ◽  
In Vivo Evaluation ◽  
Mixed Polymeric Micelles

scholarly journals Honokiol/Magnolol-Loaded Self-Assembling Lecithin-Based Mixed Polymeric Micelles (lbMPMs) for Improving Solubility to Enhance Oral Bioavailability

2021 ◽  
Vol Volume 16 ◽  
pp. 651-665
Author(s):  
Hong-Liang Lin ◽  
Wen-Ting Cheng ◽  
Ling-Chun Chen ◽  
Hsiu-O Ho ◽  
Shyr-Yi Lin ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
Polymeric Micelles ◽  
Self Assembling ◽  
Mixed Polymeric Micelles

In Vitro and In Vivo Characterization of Various Ferrites for Hyperthermia in Cancer-Treatment

2005 ◽  
pp. 827-830
Author(s):  
D.H. Kim ◽  
Se Ho Lee ◽  
Kyoung Nam Kim ◽  
Kwang Mahn Kim ◽  
I.B. Shim ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
In Vivo Characterization

scholarly journals Simultaneous Determination of Bufalin and Its Nine Metabolites in Rat Plasma for Characterization of Metabolic Profiles and Pharmacokinetic Study by LC–MS/MS

Molecules ◽  
2019 ◽  
Vol 24 (9) ◽  
pp. 1662
Author(s):  
Wenlong Wei ◽  
Yang Yu ◽  
Xia Wang ◽  
Linhui Yang ◽  
Hang Zhang ◽  
...  
Keyword(s):  
Oral Administration ◽  
Simultaneous Determination ◽  
Pharmacokinetic Study ◽  
Metabolic Pathways ◽  
Multiple Reaction Monitoring ◽  
Rat Plasma ◽  
Limit Of Quantitation

Characterization and determination of metabolites to monitor metabolic pathways play a paramount role in evaluating the efficacy and safety of medicines. However, the separation and quantification of metabolites are rather difficult due to their limited contents in vivo, especially in the case of Chinese medicine, due to its complexity. In this study, an effective and convenient method was developed to simultaneously quantify bufalin and its nine metabolites (semi-quantitation) in rat plasma after an oral administration of 10 mg/kg to rats. The prototype and metabolites that were identified were subsequently quantified using positive electrospray ionization in multiple reaction monitoring (MRM) mode with transitions of m/z 387.4→369.6 and 387.4→351.3 for bufalin, m/z 513.7→145.3 for IS, and 387.4→369.6, 419.2→365.2, and 403.2→349.2 for the main metabolites (3-epi-bufalin, dihydroxylated bufalin, and hydroxylated bufalin, respectively). The method was validated over the calibration curve range of 1.00–100 ng/mL with a limit of quantitation (LOQ) of 1 ng/mL for bufalin. No obvious matrix effect was observed, and the intra- and inter-day precisions, as well as accuracy, were all within the acceptable criteria in this method. Then, this method was successfully applied in metabolic profiling and a pharmacokinetic study of bufalin after an oral administration of 10 mg/kg to rats. The method of simultaneous determination of bufalin and its nine metabolites in rat plasma could be useful for pharmacokinetic–pharmacodynamic relationship research of bufalin, providing experimental evidence for explaining the occurrence of some adverse effects of Venenum Bufonis and its related preparations.

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