scholarly journals Single peptide ligand-functionalized uniform hollow mesoporous silica nanoparticles achieving dual-targeting drug delivery to tumor cells and angiogenic blood vessel cells

2015 ◽  
pp. 1855 ◽  
Author(s):  
Yang Liu ◽  
Qing Chen ◽  
Ming Xu ◽  
Guannan Guan ◽  
Wen Hu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Blood Vessel ◽  
Silica Nanoparticles ◽  
Tumor Cells ◽  
Mesoporous Silica Nanoparticles ◽  
Peptide Ligand ◽  
Dual Targeting ◽  
Hollow Mesoporous Silica ◽  
Single Peptide

Janus Mesoporous Silica Nanoparticles for Dual Targeting of Tumor Cells and Mitochondria

2017 ◽  
Vol 9 (32) ◽  
pp. 26697-26706 ◽  
Author(s):  
Victoria López ◽  
Maria Rocío Villegas ◽  
Verónica Rodríguez ◽  
Gonzalo Villaverde ◽  
Daniel Lozano ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Tumor Cells ◽  
Mesoporous Silica Nanoparticles ◽  
Dual Targeting

A soft–hard template approach towards hollow mesoporous silica nanoparticles with rough surfaces for controlled drug delivery and protein adsorption

2015 ◽  
Vol 3 (31) ◽  
pp. 6480-6489 ◽  
Author(s):  
Haijiao Zhang ◽  
Huijuan Xu ◽  
Minghong Wu ◽  
Yufang Zhong ◽  
Donghai Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Protein Adsorption ◽  
Rough Surfaces ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Delivery ◽  
Hard Template ◽  
Hollow Mesoporous Silica

Novel hollow mesoporous silica nanoparticles (HMSNs) with rough surfaces have been successfully prepared using a facile soft–hard template route.

Polymer-Coated Hollow Mesoporous Silica Nanoparticles for Triple-Responsive Drug Delivery

2015 ◽  
Vol 7 (32) ◽  
pp. 18179-18187 ◽  
Author(s):  
Yuanyuan Zhang ◽  
Chung Yen Ang ◽  
Menghuan Li ◽  
Si Yu Tan ◽  
Qiuyu Qu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Hollow Mesoporous Silica

Upper critical solution temperature polymer-grafted hollow mesoporous silica nanoparticles for near-infrared-irradiated drug release

2019 ◽  
Vol 7 (38) ◽  
pp. 5789-5796 ◽  
Author(s):  
Wei Hu ◽  
Xiaowen Bai ◽  
Yaping Wang ◽  
Zhentao Lei ◽  
Haipeng Luo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Near Infrared ◽  
Mesoporous Silica Nanoparticles ◽  
Solution Temperature ◽  
Critical Solution Temperature ◽  
Promising Strategy ◽  
Upper Critical Solution Temperature ◽  
Hollow Mesoporous Silica

A near-infrared (NIR)-responsive drug delivery system was established by grafting UCST polymers on the surfaces of hollow mesoporous silica nanoparticles (HMSNs) using the photothermal agent indocyanine green (ICG), which provided a new and promising strategy for drug delivery.

scholarly journals Galactosylated Chitosan-Functionalized Mesoporous Silica Nanoparticle Loading by Calcium Leucovorin for Colon Cancer Cell-Targeted Drug Delivery

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3082 ◽  
Author(s):  
Wei Liu ◽  
Fan Wang ◽  
Yongchao Zhu ◽  
Xue Li ◽  
Xiaojing Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Colon Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Tumor Cells ◽  
Targeted Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Targeted Drug ◽  
Galactosylated Chitosan

Targeted drug delivery to colon cancer cells can significantly improve the efficiency of treatment. We firstly synthesized carboxyl-modified mesoporous silica nanoparticles (MSN–COOH) via two-step synthesis, and then developed calcium leucovorin (LV)-loaded carboxyl-modified mesoporous silica nanoparticles based on galactosylated chitosan (GC), which are galectin receptor-mediated materials for colon-specific drug delivery systems. Both unmodified and functionalized nanoparticles were characterized by scanning electron microscopy (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD), Fourier transform infrared (FT-IR), nitrogen sorption, and dynamic light scattering (DLS). Drug release properties and drug loading capacity were determined by ultraviolet spectrophotometry (UV). LV@MSN–COOH/GC had a high LV loading and a drug loading of 18.07%. In vitro, its release, mainly by diffusion, was sustained release. Cell experiments showed that in SW620 cells with the galectin receptor, the LV@MSN–COOH/GC metabolized into methyl tetrahydrofolic acid (MTHF) and 5-fluorouracil (5-FU)@MSN–NH2/GC metabolized into FdUMP in vivo. MTHF and 5-fluoro-2′-deoxyuridine 5′-monophosphate (FdUMP) had combined inhibition and significantly downregulated the expression of thymidylate synthase (TS). Fluorescence microscopy and flow cytometry experiments show that MSN–COOH/GC has tumor cell targeting, which specifically recognizes and binds to the galectin receptor in tumor cells. The results show that the nano-dosing system based on GC can increase the concentrations of LV and 5-FU tumor cells and enhance their combined effect against colon cancer.

scholarly journals Hollow mesoporous silica nanoparticles for tumor vasculature targeting and PET image-guided drug delivery

Nanomedicine ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. 1233-1246 ◽  
Author(s):  
Rubel Chakravarty ◽  
Shreya Goel ◽  
Hao Hong ◽  
Feng Chen ◽  
Hector F Valdovinos ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Tumor Vasculature ◽  
Image Guided ◽  
Image Guided Drug Delivery ◽  
Hollow Mesoporous Silica
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