Polymer-Coated Hollow Mesoporous Silica Nanoparticles for Triple-Responsive Drug Delivery

2015 ◽  
Vol 7 (32) ◽  
pp. 18179-18187 ◽  
Author(s):  
Yuanyuan Zhang ◽  
Chung Yen Ang ◽  
Menghuan Li ◽  
Si Yu Tan ◽  
Qiuyu Qu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Hollow Mesoporous Silica

A soft–hard template approach towards hollow mesoporous silica nanoparticles with rough surfaces for controlled drug delivery and protein adsorption

2015 ◽  
Vol 3 (31) ◽  
pp. 6480-6489 ◽  
Author(s):  
Haijiao Zhang ◽  
Huijuan Xu ◽  
Minghong Wu ◽  
Yufang Zhong ◽  
Donghai Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Protein Adsorption ◽  
Rough Surfaces ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Delivery ◽  
Hard Template ◽  
Hollow Mesoporous Silica

Novel hollow mesoporous silica nanoparticles (HMSNs) with rough surfaces have been successfully prepared using a facile soft–hard template route.

Upper critical solution temperature polymer-grafted hollow mesoporous silica nanoparticles for near-infrared-irradiated drug release

2019 ◽  
Vol 7 (38) ◽  
pp. 5789-5796 ◽  
Author(s):  
Wei Hu ◽  
Xiaowen Bai ◽  
Yaping Wang ◽  
Zhentao Lei ◽  
Haipeng Luo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Near Infrared ◽  
Mesoporous Silica Nanoparticles ◽  
Solution Temperature ◽  
Critical Solution Temperature ◽  
Promising Strategy ◽  
Upper Critical Solution Temperature ◽  
Hollow Mesoporous Silica

A near-infrared (NIR)-responsive drug delivery system was established by grafting UCST polymers on the surfaces of hollow mesoporous silica nanoparticles (HMSNs) using the photothermal agent indocyanine green (ICG), which provided a new and promising strategy for drug delivery.

scholarly journals Hollow mesoporous silica nanoparticles for tumor vasculature targeting and PET image-guided drug delivery

Nanomedicine ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. 1233-1246 ◽  
Author(s):  
Rubel Chakravarty ◽  
Shreya Goel ◽  
Hao Hong ◽  
Feng Chen ◽  
Hector F Valdovinos ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Tumor Vasculature ◽  
Image Guided ◽  
Image Guided Drug Delivery ◽  
Hollow Mesoporous Silica

scholarly journals HOLLOW MESOPOROUS SILICA NANOPARTICLES FABRICATION FOR ANTICANCER DRUG DELIVERY

2020 ◽  
Vol 58 (1) ◽  
pp. 39 ◽  
Author(s):  
Ngoc Tram Nguyen Thi ◽  
Dai Hai Nguyen
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Agents ◽  
Pore Volume ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
High Surface ◽  
Loading Capacity ◽  
Hollow Mesoporous Silica

Mesoporous silica nanoparticles (MSNs) have attracted significant attention from researchers thanks to their high surface area and pore volume, which can increase drug loading capacity. Moreover, MSNs, with their biocompatibility and ease of surface functionalization, are seen as potential drug delivery system. However, the loading of drug into MSNs system still needs further improvement. In this study, hollow mesoporous silica nanoparticles (HMSNs) were fabricated in order to increase the drug loading capacity of nanosilica materials. The synthesized HMSNs possessed inner hollow cores that could remarkably raise the total pore volume and thus improve the capacity for cargo loading. HMSNs were synthesized according to the hard-template method with three main steps: (1) forming of solid SiO2 nanoparticles as templates, (2) forming of core-shell structure by coating MSN layers onto the templates, and (3) forming of hollow core structure by etching away the solid template. The HMSNs product was characterized by TEM, XRD, TGA and FTIR. In addition, drug loading capacity of the material was evaluated with doxorubicin as model drug. The results indicated remarkable improvement in drug loading capacity, compared to MSN sample. Cell assays on cancer lines showed high biocompatibility. These results demonstrated the potential of HMSNs in the delivery of anticancer agents.

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