scholarly journals Nanostructured lipid carrier-loaded hyaluronic acid microneedles for controlled dermal delivery of a lipophilic molecule

2013 ◽  
pp. 289 ◽  
Author(s):  
Young Choi ◽  
Sang Gon Lee ◽  
Jae Han Jeong ◽  
Kyung Min Lee ◽  
Kyu Ho Jeong ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Nanostructured Lipid Carrier ◽  
Lipophilic Molecule ◽  
Dermal Delivery

scholarly journals Preparation and Characteristics of NLC Coenzym Q10 with A Combination of Hyaluronic Acid

2019 ◽  
Vol 3 (1) ◽  
pp. 32-36
Author(s):  
Nurhidayah Sarifuddin ◽  
Widji Soerarti ◽  
Noorma Rosita
Keyword(s):  
Particle Size ◽  
Hyaluronic Acid ◽  
Stratum Corneum ◽  
Coenzyme Q10 ◽  
Surfactant Solution ◽  
The Body ◽  
Percutaneous Penetration ◽  
Nanostructured Lipid Carrier ◽  
Dark Orange ◽  
Measurement Results

Coenzyme Q10, often also known as ubiquinone, coenzyme Q10 or Q10, is soluble in lipids and is naturally present in plants, animals and in mitochondria. Coenzyme Q10 functions as an antioxidant that can protect the body from damage caused by free radicals. Hyaluronic acid is known as a hydrophilic polymer derived from polysaccharides which has the ability to increase percutaneous penetration by changing the composition of tightly arranged stratum corneum cells to increase the permeability of the skin. Nanostructured Lipid Carrier is a modification of the SLN system, consisting of a mixture of solid and liquid lipids (oil), stabilized by aqueous surfactant solution, is one method to increase drug penetration through the stratum corneum because it has several advantages. The purpose of this study was to see the effect of adding hyaluronic acid to the characteristics of the Nanostructure Lipid Carrier (NLC) as anti aging. Examination of characteristics including organoletis, pH, particle size and polidispersity index was carried out. The results of organoleptic NLC coenzym Q10-HA examination obtained dark orange color, liquid consistency, lipid efficacy odor and soft texture. The pH measurement results of the preparation ranged from 5.05-5.23. The results of the particle size examination ranged from 267-128 nm and the particle size distribution ranged between 0.308-0.200 Keywords: Coenzym Q10, Hyaluronic acid , NLC

Interactions of Hyaluronic Acid with the Skin and Implications for the Dermal Delivery of Biomacromolecules

2015 ◽  
Vol 12 (5) ◽  
pp. 1391-1401 ◽  
Author(s):  
Madeleine Witting ◽  
Alexander Boreham ◽  
Robert Brodwolf ◽  
Kateřina Vávrová ◽  
Ulrike Alexiev ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Dermal Delivery

scholarly journals Formulation and Characterization of Native and Crosslinked Hyaluronic Acid Microspheres for Dermal Delivery of Sodium Ascorbyl Phosphate: A Comparative Study

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 254 ◽  
Author(s):  
Arianna Fallacara ◽  
Filippo Marchetti ◽  
Michele Pozzoli ◽  
Ugo Raffaello Citernesi ◽  
Stefano Manfredini ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Spherical Shape ◽  
Kinetic Mechanism ◽  
High Yield ◽  
Release Kinetic ◽  
Polymer Swelling ◽  
Dermal Delivery ◽  
Emulsification Solvent Evaporation ◽  
First Time

The present work evaluates for the first time the use of urea-crosslinked hyaluronic acid (HA-CL), a novel derivative of native hyaluronic acid (HA), to produce microspheres (MS) by emulsification-solvent evaporation, for dermal delivery of sodium ascorbyl phosphate (SAP). As the term of comparison, HA MS were prepared. A pre-formulation study—investigation of the effects of polymers solutions properties (pH, viscosity) and working conditions—led to the - production of optimized HA-CL MS and HA-CL—SAP MS with: almost unimodal size distributions; mean diameter of 13.0 ± 0.7 and 9.9 ± 0.8 µm, respectively; spherical shape and rough surface; high yield, similar to HA MS and HA–SAP MS (≈ 85%). SAP was more efficiently encapsulated into HA-CL MS (78.8 ± 2.6%) compared to HA MS (69.7 ± 4.6%). Physical state, thermal properties, relative moisture stability of HA-CL MS and HA-CL–SAP MS were comparable to those of HA MS and HA–SAP MS. However, HA-CL–SAP MS exhibited an extended drug release compared to HA–SAP MS, despite the same kinetic mechanism—contemporaneous drug diffusion and polymer swelling/dissolution. Therefore, HA-CL formulation showed a greater potential as microcarrier (for encapsulation efficiency and release kinetic), that could be improved, in future, using suitable excipients.

Improving dermal delivery of hyaluronic acid by ionic liquids for attenuating skin dehydration

2020 ◽  
Vol 150 ◽  
pp. 528-535 ◽  
Author(s):  
Xiying Wu ◽  
Hongmin Zhang ◽  
Shuhua He ◽  
Qin Yu ◽  
Yi Lu ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Hyaluronic Acid ◽  
Dermal Delivery
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